Tag: pcdna3.1 zeo
Targeting CD99 compromises the oncogenic effects of the chimera EWS-FLI1 by inducing re-expression of zyxin and inhibition of Gli1 activity
Ewing sarcoma (EWS), a highly aggressive pediatric tumor, is driven by EWS-FLI1, an oncogenic transcription factor that remodels the tumor genetic landscape. Epigenetic mechanisms play a pivotal role in EWS pathogenesis, and the therapeutic value of compounds targeting epigenetic pathways is being identified in preclinical models. Here we showed that modulation of CD99, a cell…
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A novel BRET based genetic coded biosensor for apoptosis detection at deep tissue level in live animal
ANNEXIN V belongs to a household of phospholipid binding proteins which is ready to bind to negatively charged phospholipids akin to phosphatidylserine (PS) within the presence of a excessive affinity Ca2+ ion. When apoptosis happens, even at early stage, PS shall be uncovered to the surface of the cell floor from the cytoplasm facet of membrane…
Read MoreButein exhibits anti-tumor effect through intrinsic pathway of apoptosis, vimentin proteolysis, and inhibition of cancer stem cell population in the human papillary thyroid cancer cell line
Epithelial-mesenchymal transition (EMT) and most cancers stem cells (CSCs) play a vital function in metastasis of papillary thyroid most cancers (PTC). Additional mesenchymal marker vimentin is linked with metastasis and most cancers stem cell technology. Therefore, inhibition of EMT and efficient elimination of CSCs gives a novel goal for the event of recent therapeutic brokers.…
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Responses of Epibranchial Placodes to Disruptions of the FGF and BMP Signaling Pathways in Embryonic Mice
Placodes are ectodermal thickenings of the embryonic vertebrate head. Their descendants contribute to sensory organ improvement, but additionally give rise to sensory neurons of the cranial nerves. In mammals, the signaling pathways which regulate the morphogenesis and neurogenesis of epibranchial placodes, localized dorsocaudally to the pharyngeal clefts, are poorly understood. Subsequently, we carried out mouse…
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