Tag: pcr4-topo
Targeting CD99 compromises the oncogenic effects of the chimera EWS-FLI1 by inducing re-expression of zyxin and inhibition of Gli1 activity
Ewing sarcoma (EWS), a highly aggressive pediatric tumor, is driven by EWS-FLI1, an oncogenic transcription factor that remodels the tumor genetic landscape. Epigenetic mechanisms play a pivotal role in EWS pathogenesis, and the therapeutic value of compounds targeting epigenetic pathways is being identified in preclinical models. Here we showed that modulation of CD99, a cell…
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Dynamic Assay for Profiling Anti-SARS-CoV-2 Antibodies and Their ACE2/Spike RBD Neutralization Capacity
Serological assays have been broadly employed through the coronavirus illness 2019 (COVID-19) pandemic to measure antibody responses to extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to trace seroconversion in populations. Nevertheless, at present obtainable assays don’t enable willpower of neutralization capability inside the assay protocol. Moreover, industrial serology assays have a excessive purchase-in price that’s inaccessible for…
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