Targeting CD99 compromises the oncogenic effects of the chimera EWS-FLI1 by inducing re-expression of zyxin and inhibition of Gli1 activity

• Elizabeth

Ewing sarcoma (EWS), a highly aggressive pediatric tumor, is driven by EWS-FLI1, an oncogenic transcription factor that remodels the tumor genetic landscape. Epigenetic mechanisms play a pivotal role in EWS pathogenesis, and the therapeutic value of compounds targeting epigenetic pathways is being identified in preclinical models. Here we showed that modulation of CD99, a cell…