TGFBI production by macrophages contributes to an immunosuppressive microenvironment in ovarian cancer

TGFBI production by macrophages contributes to an immunosuppressive microenvironment in ovarian cancer

The tumor microenvironment evolves throughout malignant development with main modifications in non-malignant cells, cytokine networks, and the extracellular matrix (ECM). On this research, we aimed to grasp how the ECM modifications throughout neoplastic transformation of serous tubal intraepithelial carcinoma lesions (STIC) into high-grade serous ovarian cancers (HGSOC). Evaluation of the mechanical properties of human fallopian…

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