Argentine Bioethics Association

Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis

• Elizabeth
• September 20, 2020September 20, 2020
• 0

The COVID 19th pandemic has strengthened interest in the biological mechanisms underlying the complex interactions between infectious agents and human hosts. The spectrum of phenotypes associated with SARS-CoV infection-2, from the absence of symptoms of severe systemic complications, raising questions about the extent to which the variable response to coronavirus (CoVs) is influenced by host genetic variability background.

To explore current knowledge about this question, we design a systematic review covers the scientific literature published from January 2003 to June 2020, to include the study of contemporary outbreaks caused by SARS-CoV-1, mer-CoV and SARS- CoV-2 (ie SARS, mer and COVID-19 disease). Studies were eligible if human genetic variants were tested as predictors of ad hoc phenotypes.An clinical protocol for a rapid review process is designed in accordance with the paradigm of PRISMA and registered in the database Prospero (ID: CRD42020180860).

Systematic workflow provided 32 articles eligible for data abstraction (28 on SARS, 1 in Mers, 3 in COVID-19) report data on 26 cohorts invention. Most studies considered a definite clinical diagnosis as the primary outcome, varies coupled with other results (severity is most often analyzed). Ten studies analyzed HLA haplotype (1 in patients with COVID-19) and did not provide a consistent signal relationship with phenotypes related diseases. Of the 22 articles that qualify investigating candidate genes (2 as associated with COVID-19), gen top ranking in a number of studies that ACE2, CLEC4M (L-SIGN), MBL, MxA (n = 3), ACE, CD209, FCER2 , OAS-1, TLR4, TNF-α (n = 2).

Only variants in the MBL and MxA found as a possible involvement in related CoV phenotype in at least two studies. The number of studies for each predictor is not enough to perform a meta-analyses.Studies collect large cohort from different ancestors needed to further clarify the role of genetic variants in determining the host response to infection CoVs. rigorous design and robust statistical method is guaranteed.

Classification discordant frequency variants in the Human Gene Mutation Database: Comparison of the American College of Medical Genetics and Genomics and ClinVar Guidelines

Purpose: variants of classification discordant between public databases is one of the well-documented limitations when interpreting the pathogenicity of variants. The purpose of this study was to determine the level of germline variants misannotation of Human Mutation Database Gen (HGMD) and concordance between database explanation.

Methods: We used a total of 188 106 classified variants (disease causing mutation [n = 179 454] and polymorphism [n = 8652]) in 6466 genes from HGMD. All variants were reanalyzed by the American College of Medical Genetics and Genomics (ACMG) guidelines and compared with the variant database ClinVar.

Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug
QP7370-ec-200ug	EnQuireBio	200ug	EUR 760.8

Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug
QP7370-ec-500ug	EnQuireBio	500ug	EUR 1272

Recombinant Human Genome polyprotein, His, Yeast-100ug
QP7370-ye-100ug	EnQuireBio	100ug	EUR 576

Recombinant Human Genome polyprotein, His, Yeast-1mg
QP7370-ye-1mg	EnQuireBio	1mg	EUR 2262

Recombinant Human Genome polyprotein, His, Yeast-10ug
QP7370-ye-10ug	EnQuireBio	10ug	EUR 283.2

Recombinant Human Genome polyprotein, His, Yeast-50ug
QP7370-ye-50ug	EnQuireBio	50ug	EUR 358.8

Recombinant Human Genome polyprotein, His, Yeast-200ug
QP7370-ye-200ug	EnQuireBio	200ug	EUR 892.8

Recombinant Human Genome polyprotein, His, Yeast-500ug
QP7370-ye-500ug	EnQuireBio	500ug	EUR 1447.2

Recombinant JEV Genome polyprotein (aa 2528-3432) Protein
VAng-Wyb3447-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 9926.4
Description: Japanese encephalitis virus (strain Jaoars982) Genome polyprotein, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 286-730)
VAng-Cr6541-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 5751.6
Description: YFV Genome polyprotein, partial, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 286-730)
VAng-Cr6541-500gEcoli	Creative Biolabs	500 µg (E. coli)	EUR 3657.6
Description: YFV Genome polyprotein, partial, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 286-730)
VAng-Cr6541-50gEcoli	Creative Biolabs	50 µg (E. coli)	EUR 1083.6
Description: YFV Genome polyprotein, partial, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 1-101)
VAng-Cr6542-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 3408
Description: YFV Genome polyprotein, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 1-101)
VAng-Cr6542-500gEcoli	Creative Biolabs	500 µg (E. coli)	EUR 2452.8
Description: YFV Genome polyprotein, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 1-101)
VAng-Cr6542-50gEcoli	Creative Biolabs	50 µg (E. coli)	EUR 1693.2
Description: YFV Genome polyprotein, recombinant protein.

Recombinant YFV Genome polyprotein (NS4A) Protein (aa 1-3412)
VAng-Cr6545-inquire	Creative Biolabs	inquire	Ask for price
Description: YFV (isolate Uganda/A7094A4/1948) Genome polyprotein (NS4A), recombinant protein.

Genome Polyprotein Antibody
20-abx109417	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome polyprotein Antibody
1-CSB-PA18549A0Rb	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody
1-CSB-PA714772LA01HYH	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody
1-CSB-PA333180LA01HFD	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody
1-CSB-PA362073LA01HQD	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody
20-abx300967	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome polyprotein Antibody
CSB-PA4643XA11GSV	Cusabio	100ul / 50ul	EUR 299
Description: Genome polyprotein

Genome polyprotein Antibody
CSB-PA4644XA11GSW	Cusabio	100ul / 50ul	EUR 299
Description: Genome polyprotein

Human rhinovirus 1A Genome polyprotein
1-CSB-YP326367HQA	Cusabio	EUR 516.00 EUR 280.80 EUR 1809.60 EUR 770.40 EUR 1210.80 EUR 349.20	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human rhinovirus 1A Genome polyprotein,partial expressed in Yeast

Recombinant Hepatitis C Virus polyprotein, His, E.coli-100ug
QP8939-ec-100ug	EnQuireBio	100ug	EUR 848.4

Genome polyprotein Antibody (HRP)
20-abx109095	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Hepatitis C Genome polyprotein
1-CSB-RP184674Ba	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli

Genome polyprotein Antibody (HRP)
20-abx300968	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome polyprotein Antibody (FITC)
20-abx107678	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome polyprotein Antibody (FITC)
20-abx300969	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome polyprotein Antibody (Biotin)
20-abx106264	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome Polyprotein Antibody (Biotin)
20-abx105887	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome polyprotein Antibody (Biotin)
20-abx300970	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome Polyprotein Polyclonal Antibody
A68253	EpiGentek	EUR 684.66 EUR 117.70 EUR 302.50 EUR 423.50	100 µg 20 ul 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody
A68254	EpiGentek	EUR 684.66 EUR 117.70 EUR 302.50 EUR 423.50	100 µg 20 ul 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody
A56743	EpiGentek	EUR 684.66 EUR 117.70 EUR 302.50 EUR 423.50	100 µg 20 ul 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody
A56130	EpiGentek	EUR 684.66 EUR 117.70 EUR 302.50 EUR 423.50	100 µg 20 ul 50 ul 100 ul

Yellow fever virus Genome polyprotein
1-CSB-EP365905YAC1	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Yellow fever virus Genome polyprotein,partial expressed in E.coli

Genome Polyprotein (HCV-Core) Antibody
33487-05111	AssayPro	150 ug	EUR 313.2

Human rhinovirus A serotype 89 Genome polyprotein
1-CSB-EP362073HQD	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli

Human rhinovirus A serotype 89 Genome polyprotein
1-CSB-EP362073HQDb0	Cusabio	EUR 456.00 EUR 256.80 EUR 1570.80 EUR 672.00 EUR 1047.60 EUR 314.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli

Human rhinovirus A serotype 89 Genome polyprotein
1-CSB-YP362073HQD	Cusabio	EUR 516.00 EUR 280.80 EUR 1809.60 EUR 770.40 EUR 1210.80 EUR 349.20	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in Yeast

Enterovirus 71 Genome polyprotein Antibody
20-abx109758	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome polyprotein Antibody, HRP conjugated
1-CSB-PA18549B0Rb	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is HRP conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, HRP conjugated
1-CSB-PA714772LB01HYH	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is HRP conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, HRP conjugated
1-CSB-PA333180LB01HFD	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is HRP conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, HRP conjugated
1-CSB-PA362073LB01HQD	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is HRP conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, FITC conjugated
1-CSB-PA18549C0Rb	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is FITC conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, FITC conjugated
1-CSB-PA714772LC01HYH	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is FITC conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, FITC conjugated
1-CSB-PA333180LC01HFD	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is FITC conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, FITC conjugated
1-CSB-PA362073LC01HQD	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is FITC conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, Biotin conjugated
1-CSB-PA18549D0Rb	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Biotin conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, Biotin conjugated
1-CSB-PA714772LD01HYH	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Biotin conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, Biotin conjugated
1-CSB-PA333180LD01HFD	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Biotin conjugated. Tested in the following application: ELISA

Genome polyprotein Antibody, Biotin conjugated
1-CSB-PA362073LD01HQD	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Biotin conjugated. Tested in the following application: ELISA

Japanese encephalitis virus Genome polyprotein
1-CSB-EP189574Ba	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Japanese encephalitis virus Genome polyprotein,partial expressed in E.coli

Recombinant Hepatitis C Virus polyprotein, His, E.coli-1mg
QP8939-ec-1mg	EnQuireBio	1mg	EUR 2763.6

Recombinant Hepatitis C Virus polyprotein, His, E.coli-10ug
QP8939-ec-10ug	EnQuireBio	10ug	EUR 391.2

Recombinant Hepatitis C Virus polyprotein, His, E.coli-50ug
QP8939-ec-50ug	EnQuireBio	50ug	EUR 522

Recombinant Hepatitis C Virus polyprotein, His, E.coli-200ug
QP8939-ec-200ug	EnQuireBio	200ug	EUR 1338

Recombinant Hepatitis C Virus polyprotein, His, E.coli-500ug
QP8939-ec-500ug	EnQuireBio	500ug	EUR 1816.8

Enterovirus 71 Genome polyprotein Antibody (HRP)
20-abx108220	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Enterovirus 71 Genome polyprotein Antibody (FITC)
20-abx106801	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Enterovirus 71 Genome polyprotein Antibody (Biotin)
20-abx105382	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Hepatitis C virus genotype 1a Genome polyprotein
1-CSB-EP333180HFD	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in E.coli

Hepatitis C virus genotype 1b Genome polyprotein
1-CSB-YP530838HVQ(A3)	Cusabio	EUR 814.80 EUR 402.00 EUR 2606.40 EUR 1261.20 EUR 1730.40 EUR 522.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast

Hepatitis C virus genotype 1b Genome polyprotein
1-CSB-YP530838HVQ(A4)	Cusabio	EUR 814.80 EUR 402.00 EUR 2606.40 EUR 1261.20 EUR 1730.40 EUR 522.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast

Hepatitis C virus genotype 1a Genome polyprotein
1-CSB-MP333180HFD	Cusabio	EUR 351.60 EUR 1155.60 EUR 490.80 EUR 860.40	100ug 1MG 200ug 500ug
Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in Mammalian cell

Genome Polyprotein Polyclonal Antibody, HRP Conjugated
A68252	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, HRP Conjugated
A68255	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, HRP Conjugated
A56744	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, HRP Conjugated
A56131	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, FITC Conjugated
A68251	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, FITC Conjugated
A68256	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, FITC Conjugated
A56745	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, FITC Conjugated
A56132	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-100ug
QP7125-100ug	EnQuireBio	100ug	EUR 925.2

Genome Polyprotein Polyclonal Antibody, Biotin Conjugated
A68250	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, Biotin Conjugated
A68257	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, Biotin Conjugated
A56746	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Genome Polyprotein Polyclonal Antibody, Biotin Conjugated
A56133	EpiGentek	EUR 684.66 EUR 302.50 EUR 423.50	100 µg 50 ul 100 ul

Rhinovirus A serotype 89 Genome polyprotein Antibody
20-abx109372	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome Polyprotein (HCV-Core) Antibody (Biotin Conjugate)
33487-05121	AssayPro	150 ug	EUR 442.8

Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP)
20-abx108723	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC)
20-abx107303	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Genome Polyprotein (HCV-Core) AssayLite Antibody (RPE Conjugate)
33487-05151	AssayPro	150 ug	EUR 513.6

Genome Polyprotein (HCV-Core) AssayLite Antibody (APC Conjugate)
33487-05161	AssayPro	150 ug	EUR 513.6

Genome Polyprotein (HCV-Core) AssayLite Antibody (FITC Conjugate)
33487-05141	AssayPro	150 ug	EUR 513.6

Genome Polyprotein (HCV-Core) AssayLite Antibody (PerCP Conjugate)
33487-05171	AssayPro	150 ug	EUR 565.2

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-100ug
QP9739-ye-100ug	EnQuireBio	100ug	EUR 945.6

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-1mg
QP6996-1mg	EnQuireBio	1mg	EUR 3037.2

Recombinant MMTV Gag Polyprotein (aa 2-99) [His]
VAng-Lsx0591-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 3612
Description: Mouse Mammary Tumor Virus Gag Polyprotein (aa 2-99) [His], recombinant protein from E. coli.

Recombinant MMTV Gag Polyprotein (aa 2-99) [His]
VAng-Lsx0591-500gEcoli	Creative Biolabs	500 µg (E. coli)	EUR 2446.8
Description: Mouse Mammary Tumor Virus Gag Polyprotein (aa 2-99) [His], recombinant protein from E. coli.

Recombinant MMTV Gag Polyprotein (aa 2-99) [His]
VAng-Lsx0591-50gEcoli	Creative Biolabs	50 µg (E. coli)	EUR 1675.2
Description: Mouse Mammary Tumor Virus Gag Polyprotein (aa 2-99) [His], recombinant protein from E. coli.

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-10ug
QP6996-10ug	EnQuireBio	10ug	EUR 426

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-200ug
QP6996-200ug	EnQuireBio	200ug	EUR 1468.8

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-20ug
QP6996-20ug	EnQuireBio	20ug	EUR 523.2

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-500ug
QP6996-500ug	EnQuireBio	500ug	EUR 1936.8

Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-10ug
QP7125-10ug	EnQuireBio	10ug	EUR 426

Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-50ug
QP7125-50ug	EnQuireBio	50ug	EUR 567.6

Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-1mg
QP7125-1mg	EnQuireBio	1mg	EUR 3037.2

Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-200ug
QP7125-200ug	EnQuireBio	200ug	EUR 1468.8

Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-500ug
QP7125-500ug	EnQuireBio	500ug	EUR 1936.8

Recombinant JEV Polyprotein NS5 (aa 2780-3428) [His] Protein
VAng-Wyb3463-1mg	Creative Biolabs	1 mg	EUR 5982
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein.

Recombinant JEV Polyprotein NS5 (aa 2780-3428) [His] Protein
VAng-Wyb3463-500g	Creative Biolabs	500 µg	EUR 3837.6
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein.

Recombinant JEV Polyprotein NS5 (aa 2780-3428) [His] Protein
VAng-Wyb3463-50g	Creative Biolabs	50 µg	EUR 1215.6
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein.

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-1mg
QP9739-ye-1mg	EnQuireBio	1mg	EUR 3296.4

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-10ug
QP9739-ye-10ug	EnQuireBio	10ug	EUR 434.4

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-200ug
QP9739-ye-200ug	EnQuireBio	200ug	EUR 1512

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-500ug
QP9739-ye-500ug	EnQuireBio	500ug	EUR 2164.8

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-50ug
QP9739-ye-50ug	EnQuireBio	50ug	EUR 576

Recombinant CHIKV Structural Polyprotein
VAng-Lsx0030-inquire	Creative Biolabs	inquire	Ask for price
Description: CHIKV Structural Polyprotein, recombinant protein from E. coli.

Recombinant MLV Radiation Pol Polyprotein
VAng-Lsx0414-inquire	Creative Biolabs	inquire	Ask for price
Description: MLV Radiation Pol Polyprotein, recombinant protein from E. coli.

Recombinant CHIKV Non-structural Polyprotein
VAng-Lsx0031-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 5001.6
Description: CHIKV Non-structural Polyprotein, recombinant protein from E. coli.

Recombinant CHIKV Non-structural Polyprotein
VAng-Lsx0031-500gEcoli	Creative Biolabs	500 µg (E. coli)	EUR 3345.6
Description: CHIKV Non-structural Polyprotein, recombinant protein from E. coli.

Recombinant MAYV Structural polyprotein Protein
VAng-Wyb3702-inquire	Creative Biolabs	inquire	Ask for price
Description: Mayaro virus (strain Brazil) Structural polyprotein, recombinant protein.

Recombinant JEV Polyprotein NS5 (aa 2780-3428) Protein
VAng-Wyb3462-50gEcoli	Creative Biolabs	50 µg (E. coli)	EUR 687.6
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein.

Recombinant MAYV NS polyprotein Protein (aa 1005-1327)
VAng-Wyb3703-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 5586
Description: Mayaro virus (strain Brazil) Non-structural polyprotein, recombinant protein.

Recombinant MAYV NS polyprotein Protein (aa 1005-1327)
VAng-Wyb3703-500gEcoli	Creative Biolabs	500 µg (E. coli)	EUR 3640.8
Description: Mayaro virus (strain Brazil) Non-structural polyprotein, recombinant protein.

Recombinant JEV Polyprotein NS5 (aa 2780-3428) Protein
VAng-Wyb3462-1mgEcoli	Creative Biolabs	1 mg (E. coli)	EUR 3952.8
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein.

Recombinant JEV Polyprotein NS5 (aa 2780-3428) Protein
VAng-Wyb3462-500gEcoli	Creative Biolabs	500 µg (E. coli)	EUR 2535.6
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein.

Recombinant HTLV-2 gp 2 Gag-Pro-Pol Polyprotein
VAng-Lsx0325-inquire	Creative Biolabs	inquire	Ask for price
Description: HTLV-2 gp 2 Gag-Pro-Pol Polyprotein, recombinant protein from E. coli.

Recombinant MAYV Structural polyprotein Protein (aa 807-1242)
VAng-Wyb3704-100g	Creative Biolabs	100 µg	EUR 8276.4
Description: Mayaro virus (strain Brazil) Structural polyprotein, recombinant protein.

Recombinant MAYV Structural polyprotein Protein (aa 807-1242)
VAng-Wyb3704-10g	Creative Biolabs	10 µg	EUR 3606
Description: Mayaro virus (strain Brazil) Structural polyprotein, recombinant protein.

Recombinant MAYV Structural polyprotein Protein (aa 807-1242)
VAng-Wyb3704-50g	Creative Biolabs	50 µg	EUR 5272.8
Description: Mayaro virus (strain Brazil) Structural polyprotein, recombinant protein.

HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa
00117-V-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa

HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa
00115-V-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.
00116-V-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa.

HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.
00115-V-B-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.
00115-V-R-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.
00116-V-B-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate.

HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.
00115-V-F-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.
00116-V-R-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate.

HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.
00116-V-F-100ugvial	Virogen	100 ug/vial	EUR 150
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate.

HIV-1 gag Polyprotein (121-140)
H-4776.0500	Bachem	0.5mg	EUR 849.6
Description: Sum Formula: C86H138N26O34; CAS# [1815618-20-2]

HIV-1 gag Polyprotein (121-140)
H-4776.1000	Bachem	1.0mg	EUR 1488
Description: Sum Formula: C86H138N26O34; CAS# [1815618-20-2]

Polyprotein P1234 Antibody
CSB-PA329710XA31VAZ	Cusabio	100ul / 50ul	EUR 299
Description: Non-structural polyprotein (Polyprotein nsP1234) (P1234) [Cleaved into: P123, P123', mRNA-capping enzyme nsP1 (EC 2.1.1.-) (EC 2.7.7.-) (Non-structural protein 1), Protease nsP2 (EC 3.1.3.33) (EC 3.4.22.-) (EC 3.6.1.15) (EC 3.6.4.13) (Non-structural protein 2) (nsP2), Non-structural protein 3 (nsP3), Non-structural protein 3' (nsP3'), RNA-directed RNA polymerase nsP4 (EC 2.7.7.48) (Non-structural protein 4) (nsP4)]

Gag Polyprotein (gag) Antibody
20-abx317799	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Gag Polyprotein (gag) Antibody
20-abx318946	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Gag Polyprotein (GAG) Antibody
abx331332-100ul	Abbexa	100 ul	EUR 510

Turnip mosaic virus Polyprotein
1-CSB-EP2708TJM	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Turnip mosaic virus Polyprotein,partial expressed in E.coli

Gag Polyprotein (GAG) Antibody (HRP)
20-abx317800	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Gag Polyprotein (GAG) Antibody (HRP)
20-abx318947	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Gag Polyprotein (GAG) Antibody (FITC)
20-abx317801	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Gag Polyprotein (GAG) Antibody (FITC)
20-abx318948	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Gag Polyprotein (GAG) Antibody (FITC)
20-abx107749	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Structural Polyprotein (VP2) Antibody
abx224337-100ug	Abbexa	100 ug	EUR 493.2

Sindbis virus Structural polyprotein
1-CSB-CF361018SHZ	Cusabio	EUR 1635.60 EUR 764.40 EUR 1071.60	1MG 200ug 500ug
Description: Recombinant Sindbis virus Structural polyprotein,partial expressed in in vitro E.coli expression system

Sindbis virus Structural polyprotein
1-CSB-CF361018SHZb2	Cusabio	EUR 1635.60 EUR 764.40 EUR 1071.60	1MG 200ug 500ug
Description: Recombinant Sindbis virus Structural polyprotein,partial expressed in in vitro E.coli expression system

Gag Polyprotein (GAG) Antibody (Biotin)
20-abx317802	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Gag Polyprotein (GAG) Antibody (Biotin)
20-abx318949	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Gag Polyprotein (GAG) Antibody (Biotin)
20-abx106336	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1)
1-CSB-EP327230HGE	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1(ORF1),partial expressed in E.coli

Human HERV- K_7p22.1 provirus ancestral Gag polyprotein, ERVK6 E
ELI-27186h	Lifescience Market	96 Tests	EUR 988.8

Human HERV- K_3q12.3 provirus ancestral Env polyprotein, ERVK5 E
ELI-09980h	Lifescience Market	96 Tests	EUR 988.8

Human HERV-K_7p22.1 provirus ancestral Env polyprotein (ERVK-6)
1-CSB-EP724336HUa0	Cusabio	EUR 606.00 EUR 318.00 EUR 2192.40 EUR 919.20 EUR 1461.60 EUR 402.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK-6),partial expressed in E.coli

HIV-1 Gag-Pol polyprotein Antibody (HRP)
20-abx109153	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

HIV-1 Gag-Pol polyprotein Antibody (FITC)
20-abx107735	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

HIV-1 Gag-Pol polyprotein Antibody (Biotin)
20-abx106322	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Recombinant Human POLG2, His-SUMO, E.coli-100ug
QP8185-ec-100ug	EnQuireBio	100ug	EUR 489.6

Non-Structural Polyprotein Porf1 (ORF1) Antibody
20-abx300971	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK6) ELISA kit
CSB-EL007812HU-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human HERV-K_7p22.1 provirus ancestral Env polyprotein (ERVK6) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK6) ELISA kit
1-CSB-EL007812HU	Cusabio	EUR 964.80 EUR 6118.80 EUR 3244.80	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK6) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

HIV-1 Gag-Pol Polyprotein (gag-pol) Antibody
20-abx110593	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Moloney murine leukemia virus Gag polyprotein (gag)
1-CSB-EP356017MHK	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Moloney murine leukemia virus Gag polyprotein(gag) ,partial expressed in E.coli

Moloney murine leukemia virus Gag polyprotein (gag)
1-CSB-EP356017MHKe0	Cusabio	EUR 733.20 EUR 370.80 EUR 2192.40 EUR 1126.80 EUR 1461.60 EUR 476.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Moloney murine leukemia virus Gag polyprotein(gag),partial expressed in E.coli

ELISA kit for Human HERV-V_19q13.41 provirus ancestral Env polyprotein 1
EK3721	SAB	96 tests	EUR 804
Description: Enzyme-linked immunosorbent assay kit for quantification of Human HERV-V_19q13.41 provirus ancestral Env polyprotein 1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human Endogenous retrovirus group K member 6 Env polyprotein (ERVK-6)
1-CSB-EP724336HU	Cusabio	EUR 606.00 EUR 318.00 EUR 2192.40 EUR 919.20 EUR 1461.60 EUR 402.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Endogenous retrovirus group K member 6 Env polyprotein(ERVK-6),partial expressed in E.coli

Human Endogenous retrovirus group K member 6 Env polyprotein (ERVK-6)
1-CSB-YP724336HU	Cusabio	EUR 703.20 EUR 358.80 EUR 2606.40 EUR 1080.00 EUR 1730.40 EUR 458.40	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Endogenous retrovirus group K member 6 Env polyprotein(ERVK-6),partial expressed in Yeast

Results: When variants are classified by ACMG guidelines, misclassification was observed at 3.47% (2289 / 65,896) of variants. Overall suitability between HGMD and ClinVar is 97.62% (52,499 / 53,780) of the variants studied.
Conclusion: A variant in the database should be used with caution when variant pathogenicity interpreted. This study reveals misannotation frequency of variants and explanations HGMD compatibility between databases in depth.