Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis
The COVID 19th pandemic has strengthened interest in the biological mechanisms underlying the complex interactions between infectious agents and human hosts. The spectrum of phenotypes associated with SARS-CoV infection-2, from the absence of symptoms of severe systemic complications, raising questions about the extent to which the variable response to coronavirus (CoVs) is influenced by host genetic variability background.
To explore current knowledge about this question, we design a systematic review covers the scientific literature published from January 2003 to June 2020, to include the study of contemporary outbreaks caused by SARS-CoV-1, mer-CoV and SARS- CoV-2 (ie SARS, mer and COVID-19 disease). Studies were eligible if human genetic variants were tested as predictors of ad hoc phenotypes.An clinical protocol for a rapid review process is designed in accordance with the paradigm of PRISMA and registered in the database Prospero (ID: CRD42020180860).
Systematic workflow provided 32 articles eligible for data abstraction (28 on SARS, 1 in Mers, 3 in COVID-19) report data on 26 cohorts invention. Most studies considered a definite clinical diagnosis as the primary outcome, varies coupled with other results (severity is most often analyzed). Ten studies analyzed HLA haplotype (1 in patients with COVID-19) and did not provide a consistent signal relationship with phenotypes related diseases. Of the 22 articles that qualify investigating candidate genes (2 as associated with COVID-19), gen top ranking in a number of studies that ACE2, CLEC4M (L-SIGN), MBL, MxA (n = 3), ACE, CD209, FCER2 , OAS-1, TLR4, TNF-α (n = 2).
Only variants in the MBL and MxA found as a possible involvement in related CoV phenotype in at least two studies. The number of studies for each predictor is not enough to perform a meta-analyses.Studies collect large cohort from different ancestors needed to further clarify the role of genetic variants in determining the host response to infection CoVs. rigorous design and robust statistical method is guaranteed.
Classification discordant frequency variants in the Human Gene Mutation Database: Comparison of the American College of Medical Genetics and Genomics and ClinVar Guidelines
Purpose: variants of classification discordant between public databases is one of the well-documented limitations when interpreting the pathogenicity of variants. The purpose of this study was to determine the level of germline variants misannotation of Human Mutation Database Gen (HGMD) and concordance between database explanation.
Methods: We used a total of 188 106 classified variants (disease causing mutation [n = 179 454] and polymorphism [n = 8652]) in 6466 genes from HGMD. All variants were reanalyzed by the American College of Medical Genetics and Genomics (ACMG) guidelines and compared with the variant database ClinVar.
Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug |
|||
QP7370-ec-200ug | EnQuireBio | 200ug | EUR 760.8 |
Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug |
|||
QP7370-ec-500ug | EnQuireBio | 500ug | EUR 1272 |
Recombinant Human Genome polyprotein, His, Yeast-100ug |
|||
QP7370-ye-100ug | EnQuireBio | 100ug | EUR 576 |
Recombinant Human Genome polyprotein, His, Yeast-1mg |
|||
QP7370-ye-1mg | EnQuireBio | 1mg | EUR 2262 |
Recombinant Human Genome polyprotein, His, Yeast-10ug |
|||
QP7370-ye-10ug | EnQuireBio | 10ug | EUR 283.2 |
Recombinant Human Genome polyprotein, His, Yeast-50ug |
|||
QP7370-ye-50ug | EnQuireBio | 50ug | EUR 358.8 |
Recombinant Human Genome polyprotein, His, Yeast-200ug |
|||
QP7370-ye-200ug | EnQuireBio | 200ug | EUR 892.8 |
Recombinant Human Genome polyprotein, His, Yeast-500ug |
|||
QP7370-ye-500ug | EnQuireBio | 500ug | EUR 1447.2 |
Recombinant Human parechovirus 1 Genome polyprotein |
|||
CSB-YP734409HCAV | Cusabio | 9748 mg | Ask for price |
Recombinant Hepatitis C Genome polyprotein |
|||
CSB-RP184674Ba | Cusabio | 5430 mg | Ask for price |
Recombinant Hepatitis C Genome polyprotein |
|||
RPC24458-100ug | Biomatik Corporation | 100ug | EUR 721.6 |
Recombinant Hepatitis C Genome polyprotein |
|||
RPC24458-20ug | Biomatik Corporation | 20ug | EUR 448.1 |
Recombinant Human rhinovirus 1A Genome polyprotein, partial |
|||
CSB-YP326367HQA | Cusabio | 6222 mg | Ask for price |
Recombinant Human rhinovirus 1A Genome polyprotein, partial |
|||
CSB-EP326367HQA | Cusabio | 11613 mg | Ask for price |
Recombinant Human rhinovirus 1B Genome polyprotein, partial |
|||
CSB-EP320160HQB | Cusabio | 10401 mg | Ask for price |
Recombinant Human rhinovirus 1A Genome polyprotein,partial |
|||
AP72911 | SAB | each | Ask for price |
Recombinant Human rhinovirus 1A Genome polyprotein,partial |
|||
RPC25135-100ug | Biomatik Corporation | 100ug | EUR 573.1 |
Recombinant Human rhinovirus 1A Genome polyprotein,partial |
|||
RPC25135-20ug | Biomatik Corporation | 20ug | EUR 288.8 |
Recombinant Human parechovirus 2 Genome polyprotein, partial |
|||
CSB-EP529147HXJ | Cusabio | 9583 mg | Ask for price |
Recombinant Human parechovirus 1 Genome polyprotein, partial |
|||
CSB-EP734409HCAV | Cusabio | 9651 mg | Ask for price |
Recombinant JEV Genome polyprotein (aa 2528-3432) Protein |
|||
VAng-Wyb3447-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 9926.4 |
Description: Japanese encephalitis virus (strain Jaoars982) Genome polyprotein, recombinant protein. |
Recombinant Zika virus Genome polyprotein, partial |
|||
CSB-EP3643GOZ3 | Cusabio | 7769 mg | Ask for price |
Recombinant Enterovirus A71 Genome polyprotein, partial |
|||
CSB-EP3114GLA | Cusabio | 7385 mg | Ask for price |
Recombinant Enterovirus A71 Genome polyprotein, partial |
|||
CSB-EP3114GLAa2 | Cusabio | 7384 mg | Ask for price |
Recombinant Enterovirus A71 Genome polyprotein, partial |
|||
CSB-EP3114GLAe0 | Cusabio | 7511 mg | Ask for price |
Recombinant Enterovirus A71 Genome polyprotein, partial |
|||
CSB-EP3114GLAe1 | Cusabio | 7917 mg | Ask for price |
Recombinant Enterovirus A71 Genome polyprotein,partial |
|||
RPC28548-100ug | Biomatik Corporation | 100ug | EUR 801.9 |
Recombinant Enterovirus A71 Genome polyprotein,partial |
|||
RPC28548-1mg | Biomatik Corporation | 1mg | EUR 2885.2 |
Recombinant Enterovirus A71 Genome polyprotein,partial |
|||
RPC28548-20ug | Biomatik Corporation | 20ug | EUR 448.1 |
Recombinant Enterovirus A71 Genome polyprotein,partial |
|||
RPC28549-100ug | Biomatik Corporation | 100ug | EUR 801.9 |
Recombinant Enterovirus A71 Genome polyprotein,partial |
|||
RPC28549-1mg | Biomatik Corporation | 1mg | EUR 2885.2 |
Recombinant Enterovirus A71 Genome polyprotein,partial |
|||
RPC28549-20ug | Biomatik Corporation | 20ug | EUR 448.1 |
Recombinant YFV Genome polyprotein Protein (aa 286-730) |
|||
VAng-Cr6541-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 5751.6 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 286-730) |
|||
VAng-Cr6541-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3657.6 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 286-730) |
|||
VAng-Cr6541-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1083.6 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 1-101) |
|||
VAng-Cr6542-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3408 |
Description: YFV Genome polyprotein, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 1-101) |
|||
VAng-Cr6542-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2452.8 |
Description: YFV Genome polyprotein, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 1-101) |
|||
VAng-Cr6542-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1693.2 |
Description: YFV Genome polyprotein, recombinant protein. |
Recombinant Coxsackievirus B3 Genome polyprotein, partial |
|||
CSB-EP361017CRM1 | Cusabio | 8884 mg | Ask for price |
Recombinant West Nile virus Genome polyprotein, partial |
|||
CSB-EP356974WAF2 | Cusabio | 9323 mg | Ask for price |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial |
|||
CSB-YP362073HQD | Cusabio | 6387 mg | Ask for price |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial |
|||
CSB-EP362073HQD | Cusabio | 3389 mg | Ask for price |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial |
|||
CSB-EP362073HQDb0 | Cusabio | 3390 mg | Ask for price |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial |
|||
AP71163 | SAB | 1mg | EUR 1978 |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial |
|||
AP72984 | SAB | each | Ask for price |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial |
|||
AP77542 | SAB | 1mg | EUR 1978 |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial |
|||
RPC22779-100ug | Biomatik Corporation | 100ug | EUR 460.9 |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial |
|||
RPC22779-1mg | Biomatik Corporation | 1mg | EUR 2237.8 |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial |
|||
RPC22779-20ug | Biomatik Corporation | 20ug | EUR 258.7 |
Recombinant Yellow fever virus Genome polyprotein, partial |
|||
CSB-EP365905YAC1 | Cusabio | 3485 mg | Ask for price |
Recombinant Hepatitis C virus Genome polyprotein,partial |
|||
AP72393 | SAB | each | Ask for price |
Recombinant Yellow fever virus Genome polyprotein,partial |
|||
AP77947 | SAB | 1mg | EUR 2826 |
Recombinant Yellow fever virus Genome polyprotein,partial |
|||
RPC22821-100ug | Biomatik Corporation | 100ug | EUR 721.6 |
Recombinant Yellow fever virus Genome polyprotein,partial |
|||
RPC22821-1mg | Biomatik Corporation | 1mg | EUR 2884.7 |
Recombinant Yellow fever virus Genome polyprotein,partial |
|||
RPC22821-20ug | Biomatik Corporation | 20ug | EUR 448.1 |
Recombinant Human parechovirus 1 Genome polyprotein, partial, Biotinylated |
|||
CSB-EP734409HCAV-B | Cusabio | 10800 mg | Ask for price |
Recombinant Human parechovirus 2 Genome polyprotein, partial, Biotinylated |
|||
CSB-EP897051HHAL-B | Cusabio | 10843 mg | Ask for price |
Recombinant YFV Genome polyprotein (NS4A) Protein (aa 1-3412) |
|||
VAng-Cr6545-inquire | Creative Biolabs | inquire | Ask for price |
Description: YFV (isolate Uganda/A7094A4/1948) Genome polyprotein (NS4A), recombinant protein. |
Recombinant Dengue virus type 2 Genome polyprotein, partial |
|||
CSB-YP530838DCF | Cusabio | 7267 mg | Ask for price |
Recombinant Japanese encephalitis virus Genome polyprotein, partial |
|||
CSB-EP189574Ba | Cusabio | 2537 mg | Ask for price |
Recombinant Bovine viral diarrhea virus Genome polyprotein , partial |
|||
CSB-YP312464BKX1 | Cusabio | 6140 mg | Ask for price |
Recombinant Classical swine fever virus Genome polyprotein, partial |
|||
CSB-YP4953GLU | Cusabio | 12085 mg | Ask for price |
Recombinant St. louis encephalitis virus Genome polyprotein, partial |
|||
CSB-EP357746SKT | Cusabio | 9322 mg | Ask for price |
Recombinant Classical swine fever virus Genome polyprotein, partial |
|||
CSB-EP4953GLU | Cusabio | 11663 mg | Ask for price |
Recombinant Bovine viral diarrhea virus Genome polyprotein, partial |
|||
CSB-EP312464BKX1 | Cusabio | 2704 mg | Ask for price |
Recombinant Bovine viral diarrhea virus Genome polyprotein, partial |
|||
CSB-BP312464BKX1 | Cusabio | 139 mg | Ask for price |
Recombinant Classical swine fever virus Genome polyprotein, partial |
|||
CSB-BP4334GLU | Cusabio | 10139 mg | Ask for price |
Recombinant Bovine viral diarrhea virus Genome polyprotein,partial |
|||
RPC28130-100ug | Biomatik Corporation | 100ug | EUR 1544.5 |
Recombinant Bovine viral diarrhea virus Genome polyprotein,partial |
|||
RPC28130-20ug | Biomatik Corporation | 20ug | EUR 580.8 |
OPCA05394-20UG - GENOME POLYPROTEIN Recombinant Protein (isolate 1) |
|||
OPCA05394-20UG | Aviva Systems Biology | 20ug | EUR 339 |
Recombinant Dengue virus type 2 Genome polyprotein (Q1642N), partial |
|||
CSB-EP3044GLD(M) | Cusabio | 11736 mg | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
|||
CSB-YP530838HVQ(A3) | Cusabio | 6465 mg | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
|||
CSB-YP530838HVQ(A4) | Cusabio | 6466 mg | Ask for price |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
|||
CSB-EP333180HFD | Cusabio | 3004 mg | Ask for price |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
|||
CSB-MP333180HFD | Cusabio | 4998 mg | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial |
|||
AP73727 | SAB | each | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial |
|||
AP73728 | SAB | each | Ask for price |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial, Biotinylated |
|||
CSB-EP362073HQD-B | Cusabio | 7058 mg | Ask for price |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial,Biotinylated |
|||
RPC27677-100ug | Biomatik Corporation | 100ug | EUR 614.3 |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial,Biotinylated |
|||
RPC27677-1mg | Biomatik Corporation | 1mg | EUR 2373.6 |
Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial,Biotinylated |
|||
RPC27677-20ug | Biomatik Corporation | 20ug | EUR 468 |
Recombinant Tick-borne encephalitis virus Genome polyprotein, partial |
|||
CSB-EP3056GKR | Cusabio | 2646 mg | Ask for price |
Recombinant Dengue virus 2 Genome polyprotein (T2493G,G2494S,I2762T), partial |
|||
CSB-EP2239GLD(M) | Cusabio | 11735 mg | Ask for price |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-100ug |
|||
QP8939-ec-100ug | EnQuireBio | 100ug | EUR 848.4 |
Genome polyprotein Antibody |
|||
20-abx300967 | Abbexa |
|
|
Genome polyprotein Antibody |
|||
1-CSB-PA18549A0Rb | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Unconjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody |
|||
1-CSB-PA333180LA01HFD | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Unconjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody |
|||
1-CSB-PA362073LA01HQD | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Unconjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody |
|||
CSB-PA4643XA11GSV | Cusabio | 100ul / 50ul | EUR 299 |
Description: Genome polyprotein |
Genome polyprotein Antibody |
|||
CSB-PA4644XA11GSW | Cusabio | 100ul / 50ul | EUR 299 |
Description: Genome polyprotein |
Genome polyprotein Antibody |
|||
1-CSB-PA714772LA01HYH | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Unconjugated. Tested in the following application: ELISA |
Genome Polyprotein Antibody |
|||
20-abx109417 | Abbexa |
|
|
Genome polyprotein Antibody |
|||
abx300967-100g | Abbexa | 100 µg | EUR 362.5 |
Genome polyprotein Antibody |
|||
abx300967-20g | Abbexa | 20 µg | EUR 162.5 |
Genome polyprotein Antibody |
|||
abx300967-50g | Abbexa | 50 µg | EUR 250 |
Genome Polyprotein Antibody |
|||
abx109417-100l | Abbexa | 100 µl | EUR 162.5 |
Recombinant Tick-borne encephalitis virus European subtype Genome polyprotein, partial |
|||
CSB-EP318509TEM | Cusabio | 11863 mg | Ask for price |
Human rhinovirus 1A Genome polyprotein |
|||
1-CSB-YP326367HQA | Cusabio |
|
|
Description: Recombinant Human rhinovirus 1A Genome polyprotein,partial expressed in Yeast |
Recombinant Hepatitis C virus genotype 1a (isolate 1) (HCV) Genome polyprotein(E1),partial |
|||
AP70969 | SAB | 1mg | EUR 2826 |
Recombinant Tick-borne encephalitis virus Far Eastern subtype Genome polyprotein, partial |
|||
CSB-EP357187TEN | Cusabio | 11862 mg | Ask for price |
Recombinant Tick-borne encephalitis virus Far Eastern subtype Genome polyprotein, partial |
|||
CSB-EP357187TENa0 | Cusabio | 11843 mg | Ask for price |
Recombinant Tick-borne encephalitis virus Far Eastern subtype Genome polyprotein, partial |
|||
CSB-EP357187TENc7 | Cusabio | 11839 mg | Ask for price |
Hepatitis C Genome polyprotein |
|||
1-CSB-RP184674Ba | Cusabio |
|
|
Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli |
Genome polyprotein Antibody (HRP) |
|||
20-abx300968 | Abbexa |
|
|
Genome polyprotein Antibody (HRP) |
|||
20-abx109095 | Abbexa |
|
|
Genome polyprotein Antibody (HRP) |
|||
abx300968-100g | Abbexa | 100 µg | EUR 362.5 |
Genome polyprotein Antibody (HRP) |
|||
abx300968-20g | Abbexa | 20 µg | EUR 162.5 |
Genome polyprotein Antibody (HRP) |
|||
abx300968-50g | Abbexa | 50 µg | EUR 250 |
Genome polyprotein Antibody (HRP) |
|||
abx109095-100l | Abbexa | 100 µl | EUR 162.5 |
Genome polyprotein Antibody (FITC) |
|||
20-abx300969 | Abbexa |
|
|
Genome polyprotein Antibody (FITC) |
|||
20-abx107678 | Abbexa |
|
|
Genome polyprotein Antibody (FITC) |
|||
abx300969-100g | Abbexa | 100 µg | EUR 362.5 |
Genome polyprotein Antibody (FITC) |
|||
abx300969-20g | Abbexa | 20 µg | EUR 162.5 |
Genome polyprotein Antibody (FITC) |
|||
abx300969-50g | Abbexa | 50 µg | EUR 250 |
Genome polyprotein Antibody (FITC) |
|||
abx107678-100g | Abbexa | 100 µg | EUR 362.5 |
Genome polyprotein Antibody (FITC) |
|||
abx107678-20g | Abbexa | 20 µg | EUR 162.5 |
Genome polyprotein Antibody (FITC) |
|||
abx107678-50g | Abbexa | 50 µg | EUR 250 |
Genome polyprotein Antibody (Biotin) |
|||
20-abx300970 | Abbexa |
|
|
Genome Polyprotein Antibody (Biotin) |
|||
20-abx105887 | Abbexa |
|
|
Genome polyprotein Antibody (Biotin) |
|||
20-abx106264 | Abbexa |
|
|
Genome polyprotein Antibody (Biotin) |
|||
abx300970-100g | Abbexa | 100 µg | EUR 362.5 |
Genome polyprotein Antibody (Biotin) |
|||
abx300970-20g | Abbexa | 20 µg | EUR 162.5 |
Genome polyprotein Antibody (Biotin) |
|||
abx300970-50g | Abbexa | 50 µg | EUR 250 |
Genome Polyprotein Antibody (Biotin) |
|||
abx105887-100g | Abbexa | 100 µg | EUR 362.5 |
Genome Polyprotein Antibody (Biotin) |
|||
abx105887-20g | Abbexa | 20 µg | EUR 162.5 |
Genome Polyprotein Antibody (Biotin) |
|||
abx105887-50g | Abbexa | 50 µg | EUR 250 |
Genome polyprotein Antibody (Biotin) |
|||
abx106264-100g | Abbexa | 100 µg | EUR 362.5 |
Genome polyprotein Antibody (Biotin) |
|||
abx106264-20g | Abbexa | 20 µg | EUR 162.5 |
Genome polyprotein Antibody (Biotin) |
|||
abx106264-50g | Abbexa | 50 µg | EUR 250 |
Genome Polyprotein Polyclonal Antibody |
|||
A56130 | EpiGentek |
|
|
Genome Polyprotein Polyclonal Antibody |
|||
A56743 | EpiGentek |
|
|
Genome Polyprotein Polyclonal Antibody |
|||
A68253 | EpiGentek |
|
|
Genome Polyprotein Polyclonal Antibody |
|||
A68254 | EpiGentek |
|
|
Recombinant Hepatitis C Virus polyprotein, His, E.coli-1mg |
|||
QP8939-ec-1mg | EnQuireBio | 1mg | EUR 2763.6 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-10ug |
|||
QP8939-ec-10ug | EnQuireBio | 10ug | EUR 391.2 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-50ug |
|||
QP8939-ec-50ug | EnQuireBio | 50ug | EUR 522 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-200ug |
|||
QP8939-ec-200ug | EnQuireBio | 200ug | EUR 1338 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-500ug |
|||
QP8939-ec-500ug | EnQuireBio | 500ug | EUR 1816.8 |
Yellow fever virus Genome polyprotein |
|||
1-CSB-EP365905YAC1 | Cusabio |
|
|
Description: Recombinant Yellow fever virus Genome polyprotein,partial expressed in E.coli |
Human rhinovirus A serotype 89 Genome polyprotein |
|||
1-CSB-YP362073HQD | Cusabio |
|
|
Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in Yeast |
Human rhinovirus A serotype 89 Genome polyprotein |
|||
1-CSB-EP362073HQD | Cusabio |
|
|
Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli |
Human rhinovirus A serotype 89 Genome polyprotein |
|||
1-CSB-EP362073HQDb0 | Cusabio |
|
|
Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli |
Genome Polyprotein (HCV-Core) Antibody |
|||
33487-05111 | AssayPro | 150 ug | EUR 215 |
Genome polyprotein Antibody, HRP conjugated |
|||
1-CSB-PA18549B0Rb | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is HRP conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, HRP conjugated |
|||
1-CSB-PA333180LB01HFD | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is HRP conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, HRP conjugated |
|||
1-CSB-PA362073LB01HQD | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is HRP conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, HRP conjugated |
|||
1-CSB-PA714772LB01HYH | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is HRP conjugated. Tested in the following application: ELISA |
Enterovirus 71 Genome polyprotein Antibody |
|||
20-abx109758 | Abbexa |
|
|
Enterovirus 71 Genome polyprotein Antibody |
|||
abx109758-100l | Abbexa | 100 µl | EUR 162.5 |
Genome polyprotein Antibody, FITC conjugated |
|||
1-CSB-PA18549C0Rb | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is FITC conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, FITC conjugated |
|||
1-CSB-PA333180LC01HFD | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is FITC conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, FITC conjugated |
|||
1-CSB-PA362073LC01HQD | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is FITC conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, FITC conjugated |
|||
1-CSB-PA714772LC01HYH | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is FITC conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, Biotin conjugated |
|||
1-CSB-PA18549D0Rb | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, Biotin conjugated |
|||
1-CSB-PA333180LD01HFD | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, Biotin conjugated |
|||
1-CSB-PA362073LD01HQD | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, Biotin conjugated |
|||
1-CSB-PA714772LD01HYH | Cusabio |
|
|
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Japanese encephalitis virus Genome polyprotein |
|||
1-CSB-EP189574Ba | Cusabio |
|
|
Description: Recombinant Japanese encephalitis virus Genome polyprotein,partial expressed in E.coli |
Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-100ug |
|||
QP7125-100ug | EnQuireBio | 100ug | EUR 925.2 |
Enterovirus 71 Genome polyprotein Antibody (HRP) |
|||
20-abx108220 | Abbexa |
|
|
Enterovirus 71 Genome polyprotein Antibody (HRP) |
|||
abx108220-100g | Abbexa | 100 µg | EUR 362.5 |
Enterovirus 71 Genome polyprotein Antibody (HRP) |
|||
abx108220-20g | Abbexa | 20 µg | EUR 162.5 |
Enterovirus 71 Genome polyprotein Antibody (HRP) |
|||
abx108220-50g | Abbexa | 50 µg | EUR 250 |
Enterovirus 71 Genome polyprotein Antibody (FITC) |
|||
20-abx106801 | Abbexa |
|
|
Enterovirus 71 Genome polyprotein Antibody (FITC) |
|||
abx106801-100g | Abbexa | 100 µg | EUR 362.5 |
Enterovirus 71 Genome polyprotein Antibody (FITC) |
|||
abx106801-20g | Abbexa | 20 µg | EUR 162.5 |
Enterovirus 71 Genome polyprotein Antibody (FITC) |
|||
abx106801-50g | Abbexa | 50 µg | EUR 250 |
Anti-CrPV Genome polyprotein Polyclonal Antibody |
|||
AB1I144 | Antagene | 0.1mg | EUR 399 |
Enterovirus 71 Genome polyprotein Antibody (Biotin) |
|||
20-abx105382 | Abbexa |
|
|
Enterovirus 71 Genome polyprotein Antibody (Biotin) |
|||
abx105382-100g | Abbexa | 100 µg | EUR 362.5 |
Results: When variants are classified by ACMG guidelines, misclassification was observed at 3.47% (2289 / 65,896) of variants. Overall suitability between HGMD and ClinVar is 97.62% (52,499 / 53,780) of the variants studied.
Conclusion: A variant in the database should be used with caution when variant pathogenicity interpreted. This study reveals misannotation frequency of variants and explanations HGMD compatibility between databases in depth.