Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis

Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis

The COVID 19th pandemic has strengthened interest in the biological mechanisms underlying the complex interactions between infectious agents and human hosts. The spectrum of phenotypes associated with SARS-CoV infection-2, from the absence of symptoms of severe systemic complications, raising questions about the extent to which the variable response to coronavirus (CoVs) is influenced by host genetic variability background.

To explore current knowledge about this question, we design a systematic review covers the scientific literature published from January 2003 to June 2020, to include the study of contemporary outbreaks caused by SARS-CoV-1, mer-CoV and SARS- CoV-2 (ie SARS, mer and COVID-19 disease). Studies were eligible if human genetic variants were tested as predictors of ad hoc phenotypes.An clinical protocol for a rapid review process is designed in accordance with the paradigm of PRISMA and registered in the database Prospero (ID: CRD42020180860).

Systematic workflow provided 32 articles eligible for data abstraction (28 on SARS, 1 in Mers, 3 in COVID-19) report data on 26 cohorts invention. Most studies considered a definite clinical diagnosis as the primary outcome, varies coupled with other results (severity is most often analyzed). Ten studies analyzed HLA haplotype (1 in patients with COVID-19) and did not provide a consistent signal relationship with phenotypes related diseases. Of the 22 articles that qualify investigating candidate genes (2 as associated with COVID-19), gen top ranking in a number of studies that ACE2, CLEC4M (L-SIGN), MBL, MxA (n = 3), ACE, CD209, FCER2 , OAS-1, TLR4, TNF-α (n = 2).

Only variants in the MBL and MxA found as a possible involvement in related CoV phenotype in at least two studies. The number of studies for each predictor is not enough to perform a meta-analyses.Studies collect large cohort from different ancestors needed to further clarify the role of genetic variants in determining the host response to infection CoVs. rigorous design and robust statistical method is guaranteed.

 Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis
Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis

Classification discordant frequency variants in the Human Gene Mutation Database: Comparison of the American College of Medical Genetics and Genomics and ClinVar Guidelines

Purpose: variants of classification discordant between public databases is one of the well-documented limitations when interpreting the pathogenicity of variants. The purpose of this study was to determine the level of germline variants misannotation of Human Mutation Database Gen (HGMD) and concordance between database explanation.

Methods: We used a total of 188 106 classified variants (disease causing mutation [n = 179 454] and polymorphism [n = 8652]) in 6466 genes from HGMD. All variants were reanalyzed by the American College of Medical Genetics and Genomics (ACMG) guidelines and compared with the variant database ClinVar.

Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug

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Recombinant Hepatitis C Virus polyprotein, His, E.coli-100ug

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Genome polyprotein Antibody

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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA714772LA01HYH
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA18549A0Rb
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  • EUR 335.00
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA362073LA01HQD
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Unconjugated. Tested in the following application: ELISA

Genome Polyprotein Antibody

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Recombinant Human TNNI2 Protein, His, E.coli-100ug

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Recombinant Human YWHAE Protein, His, E.coli-100ug

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Recombinant Human ACPP Protein, His, E.coli-100ug

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Recombinant Human ANGPTL3 Protein, His, E.coli-100ug

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Recombinant Human En Protein, His, E.coli-100ug

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Recombinant Human IGFBP7 Protein, His, E.coli-100ug

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Recombinant Human KLK5 Protein, His, E.coli-100ug

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Recombinant Human NARS Protein, His, E.coli-100ug

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Recombinant Human SLAMF1 Protein, His, E.coli-100ug

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Recombinant Human ALDH5A1, His-SUMO, E.coli-100ug

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Recombinant Human COX4I1, His-SUMO, E.coli-100ug

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Recombinant Human d2hgdh, His-SUMO, E.coli-100ug

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Recombinant Human L2HGDH, His-SUMO, E.coli-100ug

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Recombinant Human POLG2, His-SUMO, E.coli-100ug

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Recombinant Human FDXR, His-SUMO, E.coli-100ug

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Recombinant Human IDH3G, His-SUMO, E.coli-100ug

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Recombinant E.coli ssbF Protein, His-SUMO, E.coli-100ug

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Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-100ug

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Recombinant E.coli Agmatinase Protein, His-SUMO, E.coli-100ug

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Recombinant E.coli nrdB Protein, His-SUMO, E.coli-100ug

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Recombinant E.coli plsC Protein, His-SUMO, E.coli-100ug

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Recombinant E.coli fkpA Protein, His-SUMO, E.coli-100ug

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Hepatitis C Genome polyprotein

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Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli

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Genome polyprotein Antibody (HRP)

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Description: reagents widely cited

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Genome polyprotein Antibody (FITC)

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  • EUR 411.00
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Genome polyprotein Antibody (Biotin)

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Human rhinovirus 1A Genome polyprotein

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Description: Recombinant Human rhinovirus 1A Genome polyprotein,partial expressed in Yeast

Recombinant Zika Envelope Protein, His, E.coli-100ug

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Recombinant Human AGRP Protein, His-SUMO, E.coli-100ug

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Recombinant Human Adenosylhomocysteinase Protein, His-SUMO, E.coli-100ug

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Recombinant Human AKR1C2 Protein, His-SUMO, E.coli-100ug

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Recombinant Human BTN3A3 Protein, His-SUMO, E.coli-100ug

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Recombinant Human CACNA2D1 Protein, His-SUMO, E.coli-100ug

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Recombinant Human CDK5 Protein, His-SUMO, E.coli-100ug

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Recombinant Human CEACAM6 Protein, His-SUMO, E.coli-100ug

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Recombinant Human CEACAM7 Protein, His-SUMO, E.coli-100ug

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Recombinant Human CIAO1 Protein, His-SUMO, E.coli-100ug

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Recombinant Human CRIP2 Protein, His-SUMO, E.coli-100ug

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Recombinant Human CYP11A1 Protein, His-SUMO, E.coli-100ug

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Recombinant Human DCX Protein, His-SUMO, E.coli-100ug

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Recombinant Human Desmoplakin Protein, His-SUMO, E.coli-100ug

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Recombinant Human EIF2AK2 Protein, His-SUMO, E.coli-100ug

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Recombinant Human EIF3G Protein, His-SUMO, E.coli-100ug

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Recombinant Human EIF4EBP3 Protein, His-SUMO, E.coli-100ug

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Recombinant Human EML2 Protein, His-SUMO, E.coli-100ug

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Recombinant Human BPHL Protein, His-SUMO, E.coli-100ug

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Recombinant Human Vasculin Protein, His-SUMO, E.coli-100ug

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Recombinant Human CHD1L Protein, His-SUMO, E.coli-100ug

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EUR 571

Recombinant Human VWA5B2 Protein, His-SUMO, E.coli-100ug

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Recombinant Human ACBD4 Protein, His-SUMO, E.coli-100ug

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Recombinant Human FANK1 Protein, His-SUMO, E.coli-100ug

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Recombinant Human ABHD5 Protein, His-SUMO, E.coli-100ug

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EUR 571

Recombinant Human PTPMT1 Protein, His-SUMO, E.coli-100ug

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Results: When variants are classified by ACMG guidelines, misclassification was observed at 3.47% (2289 / 65,896) of variants. Overall suitability between HGMD and ClinVar is 97.62% (52,499 / 53,780) of the variants studied.
Conclusion: A variant in the database should be used with caution when variant pathogenicity interpreted. This study reveals misannotation frequency of variants and explanations HGMD compatibility between databases in depth.

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