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Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis
The COVID 19th pandemic has strengthened interest in the biological mechanisms underlying the complex interactions between infectious agents and human hosts. The spectrum of phenotypes associated with SARS-CoV infection-2, from the absence of symptoms of severe systemic complications, raising questions about the extent to which the variable response to coronavirus (CoVs) is influenced by host genetic variability background.
To explore current knowledge about this question, we design a systematic review covers the scientific literature published from January 2003 to June 2020, to include the study of contemporary outbreaks caused by SARS-CoV-1, mer-CoV and SARS- CoV-2 (ie SARS, mer and COVID-19 disease). Studies were eligible if human genetic variants were tested as predictors of ad hoc phenotypes.An clinical protocol for a rapid review process is designed in accordance with the paradigm of PRISMA and registered in the database Prospero (ID: CRD42020180860).
Systematic workflow provided 32 articles eligible for data abstraction (28 on SARS, 1 in Mers, 3 in COVID-19) report data on 26 cohorts invention. Most studies considered a definite clinical diagnosis as the primary outcome, varies coupled with other results (severity is most often analyzed). Ten studies analyzed HLA haplotype (1 in patients with COVID-19) and did not provide a consistent signal relationship with phenotypes related diseases. Of the 22 articles that qualify investigating candidate genes (2 as associated with COVID-19), gen top ranking in a number of studies that ACE2, CLEC4M (L-SIGN), MBL, MxA (n = 3), ACE, CD209, FCER2 , OAS-1, TLR4, TNF-α (n = 2).
Only variants in the MBL and MxA found as a possible involvement in related CoV phenotype in at least two studies. The number of studies for each predictor is not enough to perform a meta-analyses.Studies collect large cohort from different ancestors needed to further clarify the role of genetic variants in determining the host response to infection CoVs. rigorous design and robust statistical method is guaranteed.
Classification discordant frequency variants in the Human Gene Mutation Database: Comparison of the American College of Medical Genetics and Genomics and ClinVar Guidelines
Purpose: variants of classification discordant between public databases is one of the well-documented limitations when interpreting the pathogenicity of variants. The purpose of this study was to determine the level of germline variants misannotation of Human Mutation Database Gen (HGMD) and concordance between database explanation.
Methods: We used a total of 188 106 classified variants (disease causing mutation [n = 179 454] and polymorphism [n = 8652]) in 6466 genes from HGMD. All variants were reanalyzed by the American College of Medical Genetics and Genomics (ACMG) guidelines and compared with the variant database ClinVar.
Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug |
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| QP7370-ec-200ug | EnQuireBio | 200ug | EUR 760.8 |
Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug |
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| QP7370-ec-500ug | EnQuireBio | 500ug | EUR 1272 |
Recombinant Human Genome polyprotein, His, Yeast-100ug |
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| QP7370-ye-100ug | EnQuireBio | 100ug | EUR 576 |
Recombinant Human Genome polyprotein, His, Yeast-1mg |
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| QP7370-ye-1mg | EnQuireBio | 1mg | EUR 2262 |
Recombinant Human Genome polyprotein, His, Yeast-10ug |
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| QP7370-ye-10ug | EnQuireBio | 10ug | EUR 283.2 |
Recombinant Human Genome polyprotein, His, Yeast-50ug |
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| QP7370-ye-50ug | EnQuireBio | 50ug | EUR 358.8 |
Recombinant Human Genome polyprotein, His, Yeast-200ug |
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| QP7370-ye-200ug | EnQuireBio | 200ug | EUR 892.8 |
Recombinant Human Genome polyprotein, His, Yeast-500ug |
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| QP7370-ye-500ug | EnQuireBio | 500ug | EUR 1447.2 |
Recombinant human Genome polyprotein |
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| MBS960928-005mg | MyBiosource | 0.05mg | EUR 695 |
Recombinant human Genome polyprotein |
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| MBS960928-02mg | MyBiosource | 0.2mg | EUR 905 |
Recombinant human Genome polyprotein |
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| MBS960928-05mg | MyBiosource | 0.5mg | EUR 990 |
Recombinant human Genome polyprotein |
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| MBS960928-1mg | MyBiosource | 1mg | EUR 1355 |
Recombinant Genome polyprotein |
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| MBS1236293-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1045 |
Recombinant Genome polyprotein |
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| MBS1236293-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 625 |
Recombinant Genome polyprotein |
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| MBS1236293-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 800 |
Recombinant Genome polyprotein |
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| MBS1236293-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 725 |
Recombinant Genome polyprotein |
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| MBS1236293-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 935 |
Recombinant Genome polyprotein |
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| MBS1141323-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 875 |
Recombinant Genome polyprotein |
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| MBS1141323-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 490 |
Recombinant Genome polyprotein |
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| MBS1141323-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 690 |
Recombinant Genome polyprotein |
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| MBS1141323-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 640 |
Recombinant Genome polyprotein |
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| MBS1141323-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 695 |
Recombinant Genome polyprotein |
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| MBS1257473-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 990 |
Recombinant Genome polyprotein |
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| MBS1257473-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 555 |
Recombinant Genome polyprotein |
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| MBS1257473-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 745 |
Recombinant Genome polyprotein |
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| MBS1257473-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 665 |
Recombinant Genome polyprotein |
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| MBS1257473-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 870 |
Recombinant Genome polyprotein |
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| MBS1068339-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 990 |
Recombinant Genome polyprotein |
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| MBS1068339-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 555 |
Recombinant Genome polyprotein |
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| MBS1068339-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 745 |
Recombinant Genome polyprotein |
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| MBS1068339-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 665 |
Recombinant Genome polyprotein |
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| MBS1068339-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 870 |
Recombinant Genome polyprotein |
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| MBS1040920-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1045 |
Recombinant Genome polyprotein |
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| MBS1040920-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 620 |
Recombinant Genome polyprotein |
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| MBS1040920-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 795 |
Recombinant Genome polyprotein |
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| MBS1040920-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 720 |
Recombinant Genome polyprotein |
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| MBS1040920-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 930 |
Recombinant Human rhinovirus 14 Genome polyprotein |
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| MBS1158398-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Human rhinovirus 14 Genome polyprotein |
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| MBS1158398-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 860 |
Recombinant Human rhinovirus 14 Genome polyprotein |
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| MBS1158398-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Human rhinovirus 14 Genome polyprotein |
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| MBS1158398-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1035 |
Recombinant Human rhinovirus 14 Genome polyprotein |
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| MBS1158398-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1135 |
Recombinant Human rhinovirus 1B Genome polyprotein |
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| MBS1154102-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Human rhinovirus 1B Genome polyprotein |
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| MBS1154102-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 855 |
Recombinant Human rhinovirus 1B Genome polyprotein |
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| MBS1154102-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Human rhinovirus 1B Genome polyprotein |
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| MBS1154102-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1030 |
Recombinant Human rhinovirus 1B Genome polyprotein |
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| MBS1154102-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1130 |
Recombinant Human rhinovirus 16 Genome polyprotein |
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| MBS1325019-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1120 |
Recombinant Human rhinovirus 16 Genome polyprotein |
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| MBS1325019-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 860 |
Recombinant Human rhinovirus 16 Genome polyprotein |
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| MBS1325019-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 995 |
Recombinant Human rhinovirus 16 Genome polyprotein |
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| MBS1325019-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 1120 |
Recombinant Human rhinovirus 16 Genome polyprotein |
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| MBS1325019-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 1225 |
Recombinant Human rhinovirus 3 Genome polyprotein |
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| MBS1326793-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1125 |
Recombinant Human rhinovirus 3 Genome polyprotein |
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| MBS1326793-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 860 |
Recombinant Human rhinovirus 3 Genome polyprotein |
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| MBS1326793-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 995 |
Recombinant Human rhinovirus 3 Genome polyprotein |
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| MBS1326793-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 1120 |
Recombinant Human rhinovirus 3 Genome polyprotein |
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| MBS1326793-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 1225 |
Recombinant Human rhinovirus 2 Genome polyprotein |
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| MBS1030888-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Human rhinovirus 2 Genome polyprotein |
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| MBS1030888-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 860 |
Recombinant Human rhinovirus 2 Genome polyprotein |
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| MBS1030888-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Human rhinovirus 2 Genome polyprotein |
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| MBS1030888-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1030 |
Recombinant Human rhinovirus 2 Genome polyprotein |
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| MBS1030888-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1135 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1327007-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1200 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1327007-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 850 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1327007-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 990 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1327007-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1020 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1327007-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1125 |
Recombinant Human enterovirus 70 Genome polyprotein |
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| MBS1260910-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1195 |
Recombinant Human enterovirus 70 Genome polyprotein |
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| MBS1260910-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 845 |
Recombinant Human enterovirus 70 Genome polyprotein |
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| MBS1260910-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 985 |
Recombinant Human enterovirus 70 Genome polyprotein |
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| MBS1260910-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1015 |
Recombinant Human enterovirus 70 Genome polyprotein |
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| MBS1260910-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1120 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1427939-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1200 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1427939-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 850 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1427939-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 990 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1427939-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1020 |
Recombinant Human enterovirus 71 Genome polyprotein |
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| MBS1427939-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1125 |
Recombinant Human parechovirus 1 Genome polyprotein |
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| CSB-YP734409HCAV | Cusabio | 9748 mg | Ask for price |
Recombinant Human parechovirus 1 Genome polyprotein |
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| CSB-YP734409HCAV-100ug | Cusabio | 100ug | Ask for price |
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Description: 1-289aa |
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Recombinant Human parechovirus 1 Genome polyprotein |
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| CSB-YP734409HCAV-1mg | Cusabio | 1mg | Ask for price |
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Description: 1-289aa |
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Recombinant Human parechovirus 1 Genome polyprotein |
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| CSB-YP734409HCAV-20ug | Cusabio | 20ug | Ask for price |
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Description: 1-289aa |
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Recombinant Human parechovirus 1 Genome polyprotein |
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| MBS1414957-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1170 |
Recombinant Human parechovirus 1 Genome polyprotein |
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| MBS1414957-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 810 |
Recombinant Human parechovirus 1 Genome polyprotein |
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| MBS1414957-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 960 |
Recombinant Human parechovirus 1 Genome polyprotein |
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| MBS1414957-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 970 |
Recombinant Human parechovirus 1 Genome polyprotein |
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| MBS1414957-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1125 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1055056-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1170 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1055056-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 810 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1055056-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 960 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1055056-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 970 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1055056-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1125 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1453047-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1120 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1453047-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 810 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1453047-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 960 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1453047-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 1080 |
Recombinant Human parechovirus 2 Genome polyprotein |
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| MBS1453047-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 1155 |
Recombinant Genome polyprotein, partial |
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| MBS1014881-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Genome polyprotein, partial |
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| MBS1088414-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human rhinovirus 1A Genome polyprotein VP1 |
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| MBS9422616-002mg | MyBiosource | 0.02mg | EUR 320 |
Recombinant Human rhinovirus 1A Genome polyprotein VP1 |
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| MBS9422616-01mg | MyBiosource | 0.1mg | EUR 540 |
Recombinant Human rhinovirus 1A Genome polyprotein VP1 |
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| MBS9422616-05mg | MyBiosource | 0.5mg | EUR 1360 |
Recombinant Human rhinovirus 1A Genome polyprotein VP1 |
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| MBS9422616-5x05mg | MyBiosource | 5x0.5mg | EUR 5965 |
Recombinant Human rhinovirus 1B Genome polyprotein, partial |
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| CSB-EP320160HQB | Cusabio | 10401 mg | Ask for price |
Recombinant Human rhinovirus 1B Genome polyprotein, partial |
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| CSB-EP320160HQB-100ug | Cusabio | 100ug | Ask for price |
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Description: 2-332aa |
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Recombinant Human rhinovirus 1B Genome polyprotein, partial |
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| CSB-EP320160HQB-1mg | Cusabio | 1mg | Ask for price |
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Description: 2-332aa |
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Recombinant Human rhinovirus 1B Genome polyprotein, partial |
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| CSB-EP320160HQB-20ug | Cusabio | 20ug | Ask for price |
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Description: 2-332aa |
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Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| CSB-EP326367HQA | Cusabio | 11613 mg | Ask for price |
Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| CSB-EP326367HQA-100ug | Cusabio | 100ug | Ask for price |
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Description: 571-857aa |
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Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| CSB-EP326367HQA-1mg | Cusabio | 1mg | Ask for price |
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Description: 571-857aa |
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Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| CSB-EP326367HQA-20ug | Cusabio | 20ug | Ask for price |
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Description: 571-857aa |
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Recombinant Human rhinovirus 1A Genome polyprotein,partial |
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| AP72911 | SAB | each | Ask for price |
Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| CSB-YP326367HQA | Cusabio | 6222 mg | Ask for price |
Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| CSB-YP326367HQA-20ug | Cusabio | 20ug | Ask for price |
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Description: 571-857aa |
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Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| MBS1220686-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 375 |
Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| MBS1220686-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 275 |
Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| MBS1220686-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 640 |
Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| MBS1220686-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 450 |
Recombinant Human rhinovirus 1A Genome polyprotein, partial |
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| MBS1220686-05mgYeast | MyBiosource | 0.5mg(Yeast) | EUR 1065 |
Recombinant Human rhinovirus 1A Genome polyprotein,partial |
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| RPC25135-100ug | Biomatik Corporation | 100ug | EUR 573.1 |
Recombinant Human rhinovirus 1A Genome polyprotein,partial |
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| RPC25135-20ug | Biomatik Corporation | 20ug | EUR 288.8 |
Recombinant Human parechovirus 2 Genome polyprotein, partial |
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| CSB-EP529147HXJ | Cusabio | 9583 mg | Ask for price |
Recombinant Human parechovirus 2 Genome polyprotein, partial |
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| CSB-EP529147HXJ-100ug | Cusabio | 100ug | Ask for price |
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Description: 1-289aa |
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Recombinant Human parechovirus 2 Genome polyprotein, partial |
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| CSB-EP529147HXJ-1mg | Cusabio | 1mg | Ask for price |
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Description: 1-289aa |
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Recombinant Human parechovirus 2 Genome polyprotein, partial |
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| CSB-EP529147HXJ-20ug | Cusabio | 20ug | Ask for price |
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Description: 1-289aa |
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Recombinant Human parechovirus 1 Genome polyprotein, partial |
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| CSB-EP734409HCAV | Cusabio | 9651 mg | Ask for price |
Recombinant Human parechovirus 1 Genome polyprotein, partial |
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| CSB-EP734409HCAV-100ug | Cusabio | 100ug | Ask for price |
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Description: 1-289aa |
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Recombinant Human parechovirus 1 Genome polyprotein, partial |
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| CSB-EP734409HCAV-1mg | Cusabio | 1mg | Ask for price |
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Description: 1-289aa |
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Recombinant Human parechovirus 1 Genome polyprotein, partial |
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| CSB-EP734409HCAV-20ug | Cusabio | 20ug | Ask for price |
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Description: 1-289aa |
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Recombinant Hepatitis C Genome polyprotein |
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| CSB-RP184674Ba | Cusabio | 5430 mg | Ask for price |
Recombinant Hepatitis C Genome polyprotein |
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| CSB-RP184674Ba-20ug | Cusabio | 20ug | Ask for price |
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Description: 1-631aa |
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Recombinant Echovirus 16 Genome polyprotein |
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| MBS1346831-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Echovirus 16 Genome polyprotein |
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| MBS1346831-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 860 |
Recombinant Echovirus 16 Genome polyprotein |
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| MBS1346831-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Echovirus 16 Genome polyprotein |
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| MBS1346831-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1035 |
Recombinant Echovirus 16 Genome polyprotein |
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| MBS1346831-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1135 |
Recombinant Echovirus 11 Genome polyprotein |
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| MBS1164799-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Echovirus 11 Genome polyprotein |
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| MBS1164799-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 860 |
Recombinant Echovirus 11 Genome polyprotein |
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| MBS1164799-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Echovirus 11 Genome polyprotein |
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| MBS1164799-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1035 |
Recombinant Echovirus 11 Genome polyprotein |
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| MBS1164799-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1135 |
Recombinant Langat virus Genome polyprotein |
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| MBS1133753-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Echovirus 9 Genome polyprotein |
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| MBS1369865-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Echovirus 9 Genome polyprotein |
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| MBS1369865-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 860 |
Recombinant Echovirus 9 Genome polyprotein |
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| MBS1369865-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Echovirus 9 Genome polyprotein |
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| MBS1369865-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1030 |
Recombinant Echovirus 9 Genome polyprotein |
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| MBS1369865-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1135 |
Recombinant Echovirus 6 Genome polyprotein |
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| MBS1393297-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Echovirus 6 Genome polyprotein |
|||
| MBS1393297-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 860 |
Recombinant Echovirus 6 Genome polyprotein |
|||
| MBS1393297-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Echovirus 6 Genome polyprotein |
|||
| MBS1393297-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1030 |
Recombinant Echovirus 6 Genome polyprotein |
|||
| MBS1393297-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1135 |
Recombinant Echovirus 12 Genome polyprotein |
|||
| MBS1285198-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Echovirus 12 Genome polyprotein |
|||
| MBS1285198-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 860 |
Recombinant Echovirus 12 Genome polyprotein |
|||
| MBS1285198-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Echovirus 12 Genome polyprotein |
|||
| MBS1285198-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1030 |
Recombinant Echovirus 12 Genome polyprotein |
|||
| MBS1285198-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1135 |
Recombinant Echovirus 1 Genome polyprotein |
|||
| MBS1036392-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Echovirus 1 Genome polyprotein |
|||
| MBS1036392-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 860 |
Recombinant Echovirus 1 Genome polyprotein |
|||
| MBS1036392-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Echovirus 1 Genome polyprotein |
|||
| MBS1036392-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1030 |
Recombinant Echovirus 1 Genome polyprotein |
|||
| MBS1036392-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1135 |
Recombinant Echovirus 9 Genome polyprotein |
|||
| MBS1461867-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1205 |
Recombinant Echovirus 9 Genome polyprotein |
|||
| MBS1461867-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 860 |
Recombinant Echovirus 9 Genome polyprotein |
|||
| MBS1461867-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 995 |
Recombinant Echovirus 9 Genome polyprotein |
|||
| MBS1461867-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 1030 |
Recombinant Echovirus 9 Genome polyprotein |
|||
| MBS1461867-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 1135 |
Recombinant Echovirus 30 Genome polyprotein |
|||
| MBS1479634-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1120 |
Recombinant Echovirus 30 Genome polyprotein |
|||
| MBS1479634-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 860 |
Recombinant Echovirus 30 Genome polyprotein |
|||
| MBS1479634-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 995 |
Recombinant Echovirus 30 Genome polyprotein |
|||
| MBS1479634-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 1120 |
Results: When variants are classified by ACMG guidelines, misclassification was observed at 3.47% (2289 / 65,896) of variants. Overall suitability between HGMD and ClinVar is 97.62% (52,499 / 53,780) of the variants studied.
Conclusion: A variant in the database should be used with caution when variant pathogenicity interpreted. This study reveals misannotation frequency of variants and explanations HGMD compatibility between databases in depth.
