
Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): rapid systematic review and field synopsis
The COVID 19th pandemic has strengthened interest in the biological mechanisms underlying the complex interactions between infectious agents and human hosts. The spectrum of phenotypes associated with SARS-CoV infection-2, from the absence of symptoms of severe systemic complications, raising questions about the extent to which the variable response to coronavirus (CoVs) is influenced by host genetic variability background.
To explore current knowledge about this question, we design a systematic review covers the scientific literature published from January 2003 to June 2020, to include the study of contemporary outbreaks caused by SARS-CoV-1, mer-CoV and SARS- CoV-2 (ie SARS, mer and COVID-19 disease). Studies were eligible if human genetic variants were tested as predictors of ad hoc phenotypes.An clinical protocol for a rapid review process is designed in accordance with the paradigm of PRISMA and registered in the database Prospero (ID: CRD42020180860).
Systematic workflow provided 32 articles eligible for data abstraction (28 on SARS, 1 in Mers, 3 in COVID-19) report data on 26 cohorts invention. Most studies considered a definite clinical diagnosis as the primary outcome, varies coupled with other results (severity is most often analyzed). Ten studies analyzed HLA haplotype (1 in patients with COVID-19) and did not provide a consistent signal relationship with phenotypes related diseases. Of the 22 articles that qualify investigating candidate genes (2 as associated with COVID-19), gen top ranking in a number of studies that ACE2, CLEC4M (L-SIGN), MBL, MxA (n = 3), ACE, CD209, FCER2 , OAS-1, TLR4, TNF-α (n = 2).
Only variants in the MBL and MxA found as a possible involvement in related CoV phenotype in at least two studies. The number of studies for each predictor is not enough to perform a meta-analyses.Studies collect large cohort from different ancestors needed to further clarify the role of genetic variants in determining the host response to infection CoVs. rigorous design and robust statistical method is guaranteed.

Classification discordant frequency variants in the Human Gene Mutation Database: Comparison of the American College of Medical Genetics and Genomics and ClinVar Guidelines
Purpose: variants of classification discordant between public databases is one of the well-documented limitations when interpreting the pathogenicity of variants. The purpose of this study was to determine the level of germline variants misannotation of Human Mutation Database Gen (HGMD) and concordance between database explanation.
Methods: We used a total of 188 106 classified variants (disease causing mutation [n = 179 454] and polymorphism [n = 8652]) in 6466 genes from HGMD. All variants were reanalyzed by the American College of Medical Genetics and Genomics (ACMG) guidelines and compared with the variant database ClinVar.
Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug |
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QP7370-ec-200ug | EnQuireBio | 200ug | EUR 760.8 |
Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug |
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QP7370-ec-500ug | EnQuireBio | 500ug | EUR 1272 |
Recombinant Human Genome polyprotein, His, Yeast-100ug |
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QP7370-ye-100ug | EnQuireBio | 100ug | EUR 576 |
Recombinant Human Genome polyprotein, His, Yeast-1mg |
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QP7370-ye-1mg | EnQuireBio | 1mg | EUR 2262 |
Recombinant Human Genome polyprotein, His, Yeast-10ug |
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QP7370-ye-10ug | EnQuireBio | 10ug | EUR 283.2 |
Recombinant Human Genome polyprotein, His, Yeast-50ug |
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QP7370-ye-50ug | EnQuireBio | 50ug | EUR 358.8 |
Recombinant Human Genome polyprotein, His, Yeast-200ug |
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QP7370-ye-200ug | EnQuireBio | 200ug | EUR 892.8 |
Recombinant Human Genome polyprotein, His, Yeast-500ug |
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QP7370-ye-500ug | EnQuireBio | 500ug | EUR 1447.2 |
Recombinant JEV Genome polyprotein (aa 2528-3432) Protein |
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VAng-Wyb3447-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 9926.4 |
Description: Japanese encephalitis virus (strain Jaoars982) Genome polyprotein, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 286-730) |
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VAng-Cr6541-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 5751.6 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 286-730) |
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VAng-Cr6541-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3657.6 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 286-730) |
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VAng-Cr6541-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1083.6 |
Description: YFV Genome polyprotein, partial, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 1-101) |
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VAng-Cr6542-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3408 |
Description: YFV Genome polyprotein, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 1-101) |
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VAng-Cr6542-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2452.8 |
Description: YFV Genome polyprotein, recombinant protein. |
Recombinant YFV Genome polyprotein Protein (aa 1-101) |
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VAng-Cr6542-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1693.2 |
Description: YFV Genome polyprotein, recombinant protein. |
Recombinant YFV Genome polyprotein (NS4A) Protein (aa 1-3412) |
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VAng-Cr6545-inquire | Creative Biolabs | inquire | Ask for price |
Description: YFV (isolate Uganda/A7094A4/1948) Genome polyprotein (NS4A), recombinant protein. |
Genome Polyprotein Antibody |
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20-abx109417 | Abbexa |
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Genome polyprotein Antibody |
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1-CSB-PA18549A0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Unconjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody |
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1-CSB-PA714772LA01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Unconjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody |
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1-CSB-PA333180LA01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Unconjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody |
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1-CSB-PA362073LA01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Unconjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody |
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20-abx300967 | Abbexa |
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Genome polyprotein Antibody |
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CSB-PA4643XA11GSV | Cusabio | 100ul / 50ul | EUR 299 |
Description: Genome polyprotein |
Genome polyprotein Antibody |
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CSB-PA4644XA11GSW | Cusabio | 100ul / 50ul | EUR 299 |
Description: Genome polyprotein |
Human rhinovirus 1A Genome polyprotein |
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1-CSB-YP326367HQA | Cusabio |
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Description: Recombinant Human rhinovirus 1A Genome polyprotein,partial expressed in Yeast |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-100ug |
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QP8939-ec-100ug | EnQuireBio | 100ug | EUR 848.4 |
Genome polyprotein Antibody (HRP) |
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20-abx109095 | Abbexa |
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Hepatitis C Genome polyprotein |
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1-CSB-RP184674Ba | Cusabio |
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Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli |
Genome polyprotein Antibody (HRP) |
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20-abx300968 | Abbexa |
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Genome polyprotein Antibody (FITC) |
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20-abx107678 | Abbexa |
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Genome polyprotein Antibody (FITC) |
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20-abx300969 | Abbexa |
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Genome polyprotein Antibody (Biotin) |
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20-abx106264 | Abbexa |
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Genome Polyprotein Antibody (Biotin) |
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20-abx105887 | Abbexa |
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Genome polyprotein Antibody (Biotin) |
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20-abx300970 | Abbexa |
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Genome Polyprotein Polyclonal Antibody |
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A68253 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody |
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A68254 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody |
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A56743 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody |
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A56130 | EpiGentek |
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Yellow fever virus Genome polyprotein |
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1-CSB-EP365905YAC1 | Cusabio |
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Description: Recombinant Yellow fever virus Genome polyprotein,partial expressed in E.coli |
Genome Polyprotein (HCV-Core) Antibody |
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33487-05111 | AssayPro | 150 ug | EUR 313.2 |
Human rhinovirus A serotype 89 Genome polyprotein |
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1-CSB-EP362073HQD | Cusabio |
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli |
Human rhinovirus A serotype 89 Genome polyprotein |
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1-CSB-EP362073HQDb0 | Cusabio |
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli |
Human rhinovirus A serotype 89 Genome polyprotein |
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1-CSB-YP362073HQD | Cusabio |
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in Yeast |
Enterovirus 71 Genome polyprotein Antibody |
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20-abx109758 | Abbexa |
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Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA18549B0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is HRP conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA714772LB01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is HRP conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA333180LB01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is HRP conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, HRP conjugated |
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1-CSB-PA362073LB01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is HRP conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA18549C0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is FITC conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA714772LC01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is FITC conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA333180LC01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is FITC conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, FITC conjugated |
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1-CSB-PA362073LC01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is FITC conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA18549D0Rb | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA714772LD01HYH | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA333180LD01HFD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Genome polyprotein Antibody, Biotin conjugated |
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1-CSB-PA362073LD01HQD | Cusabio |
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Japanese encephalitis virus Genome polyprotein |
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1-CSB-EP189574Ba | Cusabio |
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Description: Recombinant Japanese encephalitis virus Genome polyprotein,partial expressed in E.coli |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-1mg |
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QP8939-ec-1mg | EnQuireBio | 1mg | EUR 2763.6 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-10ug |
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QP8939-ec-10ug | EnQuireBio | 10ug | EUR 391.2 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-50ug |
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QP8939-ec-50ug | EnQuireBio | 50ug | EUR 522 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-200ug |
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QP8939-ec-200ug | EnQuireBio | 200ug | EUR 1338 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-500ug |
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QP8939-ec-500ug | EnQuireBio | 500ug | EUR 1816.8 |
Enterovirus 71 Genome polyprotein Antibody (HRP) |
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20-abx108220 | Abbexa |
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Enterovirus 71 Genome polyprotein Antibody (FITC) |
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20-abx106801 | Abbexa |
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Enterovirus 71 Genome polyprotein Antibody (Biotin) |
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20-abx105382 | Abbexa |
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Hepatitis C virus genotype 1a Genome polyprotein |
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1-CSB-EP333180HFD | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in E.coli |
Hepatitis C virus genotype 1b Genome polyprotein |
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1-CSB-YP530838HVQ(A3) | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast |
Hepatitis C virus genotype 1b Genome polyprotein |
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1-CSB-YP530838HVQ(A4) | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast |
Hepatitis C virus genotype 1a Genome polyprotein |
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1-CSB-MP333180HFD | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in Mammalian cell |
Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A68252 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A68255 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A56744 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, HRP Conjugated |
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A56131 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A68251 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A68256 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A56745 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, FITC Conjugated |
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A56132 | EpiGentek |
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Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-100ug |
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QP7125-100ug | EnQuireBio | 100ug | EUR 925.2 |
Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A68250 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A68257 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A56746 | EpiGentek |
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Genome Polyprotein Polyclonal Antibody, Biotin Conjugated |
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A56133 | EpiGentek |
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Rhinovirus A serotype 89 Genome polyprotein Antibody |
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20-abx109372 | Abbexa |
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Genome Polyprotein (HCV-Core) Antibody (Biotin Conjugate) |
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33487-05121 | AssayPro | 150 ug | EUR 442.8 |
Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP) |
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20-abx108723 | Abbexa |
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Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC) |
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20-abx107303 | Abbexa |
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Genome Polyprotein (HCV-Core) AssayLite Antibody (RPE Conjugate) |
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33487-05151 | AssayPro | 150 ug | EUR 513.6 |
Genome Polyprotein (HCV-Core) AssayLite Antibody (APC Conjugate) |
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33487-05161 | AssayPro | 150 ug | EUR 513.6 |
Genome Polyprotein (HCV-Core) AssayLite Antibody (FITC Conjugate) |
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33487-05141 | AssayPro | 150 ug | EUR 513.6 |
Genome Polyprotein (HCV-Core) AssayLite Antibody (PerCP Conjugate) |
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33487-05171 | AssayPro | 150 ug | EUR 565.2 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-100ug |
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QP9739-ye-100ug | EnQuireBio | 100ug | EUR 945.6 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-1mg |
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QP6996-1mg | EnQuireBio | 1mg | EUR 3037.2 |
Recombinant MMTV Gag Polyprotein (aa 2-99) [His] |
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VAng-Lsx0591-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3612 |
Description: Mouse Mammary Tumor Virus Gag Polyprotein (aa 2-99) [His], recombinant protein from E. coli. |
Recombinant MMTV Gag Polyprotein (aa 2-99) [His] |
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VAng-Lsx0591-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2446.8 |
Description: Mouse Mammary Tumor Virus Gag Polyprotein (aa 2-99) [His], recombinant protein from E. coli. |
Recombinant MMTV Gag Polyprotein (aa 2-99) [His] |
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VAng-Lsx0591-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 1675.2 |
Description: Mouse Mammary Tumor Virus Gag Polyprotein (aa 2-99) [His], recombinant protein from E. coli. |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-10ug |
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QP6996-10ug | EnQuireBio | 10ug | EUR 426 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-200ug |
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QP6996-200ug | EnQuireBio | 200ug | EUR 1468.8 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-20ug |
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QP6996-20ug | EnQuireBio | 20ug | EUR 523.2 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-500ug |
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QP6996-500ug | EnQuireBio | 500ug | EUR 1936.8 |
Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-10ug |
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QP7125-10ug | EnQuireBio | 10ug | EUR 426 |
Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-50ug |
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QP7125-50ug | EnQuireBio | 50ug | EUR 567.6 |
Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-1mg |
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QP7125-1mg | EnQuireBio | 1mg | EUR 3037.2 |
Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-200ug |
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QP7125-200ug | EnQuireBio | 200ug | EUR 1468.8 |
Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-500ug |
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QP7125-500ug | EnQuireBio | 500ug | EUR 1936.8 |
Recombinant JEV Polyprotein NS5 (aa 2780-3428) [His] Protein |
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VAng-Wyb3463-1mg | Creative Biolabs | 1 mg | EUR 5982 |
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein. |
Recombinant JEV Polyprotein NS5 (aa 2780-3428) [His] Protein |
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VAng-Wyb3463-500g | Creative Biolabs | 500 µg | EUR 3837.6 |
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein. |
Recombinant JEV Polyprotein NS5 (aa 2780-3428) [His] Protein |
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VAng-Wyb3463-50g | Creative Biolabs | 50 µg | EUR 1215.6 |
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein. |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-1mg |
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QP9739-ye-1mg | EnQuireBio | 1mg | EUR 3296.4 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-10ug |
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QP9739-ye-10ug | EnQuireBio | 10ug | EUR 434.4 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-200ug |
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QP9739-ye-200ug | EnQuireBio | 200ug | EUR 1512 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-500ug |
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QP9739-ye-500ug | EnQuireBio | 500ug | EUR 2164.8 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-50ug |
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QP9739-ye-50ug | EnQuireBio | 50ug | EUR 576 |
Recombinant CHIKV Structural Polyprotein |
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VAng-Lsx0030-inquire | Creative Biolabs | inquire | Ask for price |
Description: CHIKV Structural Polyprotein, recombinant protein from E. coli. |
Recombinant MLV Radiation Pol Polyprotein |
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VAng-Lsx0414-inquire | Creative Biolabs | inquire | Ask for price |
Description: MLV Radiation Pol Polyprotein, recombinant protein from E. coli. |
Recombinant CHIKV Non-structural Polyprotein |
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VAng-Lsx0031-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 5001.6 |
Description: CHIKV Non-structural Polyprotein, recombinant protein from E. coli. |
Recombinant CHIKV Non-structural Polyprotein |
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VAng-Lsx0031-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3345.6 |
Description: CHIKV Non-structural Polyprotein, recombinant protein from E. coli. |
Recombinant MAYV Structural polyprotein Protein |
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VAng-Wyb3702-inquire | Creative Biolabs | inquire | Ask for price |
Description: Mayaro virus (strain Brazil) Structural polyprotein, recombinant protein. |
Recombinant JEV Polyprotein NS5 (aa 2780-3428) Protein |
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VAng-Wyb3462-50gEcoli | Creative Biolabs | 50 µg (E. coli) | EUR 687.6 |
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein. |
Recombinant MAYV NS polyprotein Protein (aa 1005-1327) |
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VAng-Wyb3703-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 5586 |
Description: Mayaro virus (strain Brazil) Non-structural polyprotein, recombinant protein. |
Recombinant MAYV NS polyprotein Protein (aa 1005-1327) |
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VAng-Wyb3703-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 3640.8 |
Description: Mayaro virus (strain Brazil) Non-structural polyprotein, recombinant protein. |
Recombinant JEV Polyprotein NS5 (aa 2780-3428) Protein |
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VAng-Wyb3462-1mgEcoli | Creative Biolabs | 1 mg (E. coli) | EUR 3952.8 |
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein. |
Recombinant JEV Polyprotein NS5 (aa 2780-3428) Protein |
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VAng-Wyb3462-500gEcoli | Creative Biolabs | 500 µg (E. coli) | EUR 2535.6 |
Description: Japanese encephalitis virus Polyprotein NS5 protein, recombinant protein. |
Recombinant HTLV-2 gp 2 Gag-Pro-Pol Polyprotein |
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VAng-Lsx0325-inquire | Creative Biolabs | inquire | Ask for price |
Description: HTLV-2 gp 2 Gag-Pro-Pol Polyprotein, recombinant protein from E. coli. |
Recombinant MAYV Structural polyprotein Protein (aa 807-1242) |
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VAng-Wyb3704-100g | Creative Biolabs | 100 µg | EUR 8276.4 |
Description: Mayaro virus (strain Brazil) Structural polyprotein, recombinant protein. |
Recombinant MAYV Structural polyprotein Protein (aa 807-1242) |
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VAng-Wyb3704-10g | Creative Biolabs | 10 µg | EUR 3606 |
Description: Mayaro virus (strain Brazil) Structural polyprotein, recombinant protein. |
Recombinant MAYV Structural polyprotein Protein (aa 807-1242) |
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VAng-Wyb3704-50g | Creative Biolabs | 50 µg | EUR 5272.8 |
Description: Mayaro virus (strain Brazil) Structural polyprotein, recombinant protein. |
HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
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00117-V-100ugvial | Virogen | 100 ug/vial | EUR 150 |
Description: HCV NS3 recombinant antigen a.a 1400 to a.a 1643 of HCV polyprotein 22 kDa |
HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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00115-V-100ugvial | Virogen | 100 ug/vial | EUR 150 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
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00116-V-100ugvial | Virogen | 100 ug/vial | EUR 150 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. |
HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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00115-V-B-100ugvial | Virogen | 100 ug/vial | EUR 150 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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00115-V-R-100ugvial | Virogen | 100 ug/vial | EUR 150 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
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00116-V-B-100ugvial | Virogen | 100 ug/vial | EUR 150 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Biotin conjugate. |
HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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00115-V-F-100ugvial | Virogen | 100 ug/vial | EUR 150 |
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
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00116-V-R-100ugvial | Virogen | 100 ug/vial | EUR 150 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Rhodamine conjugate. |
HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
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00116-V-F-100ugvial | Virogen | 100 ug/vial | EUR 150 |
Description: HCV NS4 recombinant antigen NS4a+b a.a 1658 to a.a 1863 of HCV polyprotein, 19 kDa. Fluorescein conjugate. |
HIV-1 gag Polyprotein (121-140) |
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H-4776.0500 | Bachem | 0.5mg | EUR 849.6 |
Description: Sum Formula: C86H138N26O34; CAS# [1815618-20-2] |
HIV-1 gag Polyprotein (121-140) |
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H-4776.1000 | Bachem | 1.0mg | EUR 1488 |
Description: Sum Formula: C86H138N26O34; CAS# [1815618-20-2] |
Polyprotein P1234 Antibody |
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CSB-PA329710XA31VAZ | Cusabio | 100ul / 50ul | EUR 299 |
Description: Non-structural polyprotein (Polyprotein nsP1234) (P1234) [Cleaved into: P123, P123', mRNA-capping enzyme nsP1 (EC 2.1.1.-) (EC 2.7.7.-) (Non-structural protein 1), Protease nsP2 (EC 3.1.3.33) (EC 3.4.22.-) (EC 3.6.1.15) (EC 3.6.4.13) (Non-structural protein 2) (nsP2), Non-structural protein 3 (nsP3), Non-structural protein 3' (nsP3'), RNA-directed RNA polymerase nsP4 (EC 2.7.7.48) (Non-structural protein 4) (nsP4)] |
Gag Polyprotein (gag) Antibody |
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20-abx317799 | Abbexa |
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Gag Polyprotein (gag) Antibody |
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20-abx318946 | Abbexa |
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Gag Polyprotein (GAG) Antibody |
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abx331332-100ul | Abbexa | 100 ul | EUR 510 |
Turnip mosaic virus Polyprotein |
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1-CSB-EP2708TJM | Cusabio |
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Description: Recombinant Turnip mosaic virus Polyprotein,partial expressed in E.coli |
Gag Polyprotein (GAG) Antibody (HRP) |
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20-abx317800 | Abbexa |
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Gag Polyprotein (GAG) Antibody (HRP) |
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20-abx318947 | Abbexa |
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Gag Polyprotein (GAG) Antibody (FITC) |
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20-abx317801 | Abbexa |
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Gag Polyprotein (GAG) Antibody (FITC) |
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20-abx318948 | Abbexa |
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Gag Polyprotein (GAG) Antibody (FITC) |
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20-abx107749 | Abbexa |
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Structural Polyprotein (VP2) Antibody |
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abx224337-100ug | Abbexa | 100 ug | EUR 493.2 |
Sindbis virus Structural polyprotein |
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1-CSB-CF361018SHZ | Cusabio |
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Description: Recombinant Sindbis virus Structural polyprotein,partial expressed in in vitro E.coli expression system |
Sindbis virus Structural polyprotein |
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1-CSB-CF361018SHZb2 | Cusabio |
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Description: Recombinant Sindbis virus Structural polyprotein,partial expressed in in vitro E.coli expression system |
Gag Polyprotein (GAG) Antibody (Biotin) |
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20-abx317802 | Abbexa |
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Gag Polyprotein (GAG) Antibody (Biotin) |
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20-abx318949 | Abbexa |
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Gag Polyprotein (GAG) Antibody (Biotin) |
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20-abx106336 | Abbexa |
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Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1) |
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1-CSB-EP327230HGE | Cusabio |
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Description: Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1(ORF1),partial expressed in E.coli |
Human HERV- K_7p22.1 provirus ancestral Gag polyprotein, ERVK6 E |
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ELI-27186h | Lifescience Market | 96 Tests | EUR 988.8 |
Human HERV- K_3q12.3 provirus ancestral Env polyprotein, ERVK5 E |
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ELI-09980h | Lifescience Market | 96 Tests | EUR 988.8 |
Human HERV-K_7p22.1 provirus ancestral Env polyprotein (ERVK-6) |
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1-CSB-EP724336HUa0 | Cusabio |
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Description: Recombinant Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK-6),partial expressed in E.coli |
HIV-1 Gag-Pol polyprotein Antibody (HRP) |
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20-abx109153 | Abbexa |
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HIV-1 Gag-Pol polyprotein Antibody (FITC) |
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20-abx107735 | Abbexa |
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HIV-1 Gag-Pol polyprotein Antibody (Biotin) |
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20-abx106322 | Abbexa |
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Recombinant Human POLG2, His-SUMO, E.coli-100ug |
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QP8185-ec-100ug | EnQuireBio | 100ug | EUR 489.6 |
Non-Structural Polyprotein Porf1 (ORF1) Antibody |
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20-abx300971 | Abbexa |
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Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK6) ELISA kit |
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CSB-EL007812HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human HERV-K_7p22.1 provirus ancestral Env polyprotein (ERVK6) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK6) ELISA kit |
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1-CSB-EL007812HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human HERV-K_7p22.1 provirus ancestral Env polyprotein(ERVK6) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
HIV-1 Gag-Pol Polyprotein (gag-pol) Antibody |
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20-abx110593 | Abbexa |
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Moloney murine leukemia virus Gag polyprotein (gag) |
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1-CSB-EP356017MHK | Cusabio |
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Description: Recombinant Moloney murine leukemia virus Gag polyprotein(gag) ,partial expressed in E.coli |
Moloney murine leukemia virus Gag polyprotein (gag) |
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1-CSB-EP356017MHKe0 | Cusabio |
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Description: Recombinant Moloney murine leukemia virus Gag polyprotein(gag),partial expressed in E.coli |
ELISA kit for Human HERV-V_19q13.41 provirus ancestral Env polyprotein 1 |
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EK3721 | SAB | 96 tests | EUR 804 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human HERV-V_19q13.41 provirus ancestral Env polyprotein 1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
Human Endogenous retrovirus group K member 6 Env polyprotein (ERVK-6) |
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1-CSB-EP724336HU | Cusabio |
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Description: Recombinant Human Endogenous retrovirus group K member 6 Env polyprotein(ERVK-6),partial expressed in E.coli |
Human Endogenous retrovirus group K member 6 Env polyprotein (ERVK-6) |
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1-CSB-YP724336HU | Cusabio |
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Description: Recombinant Human Endogenous retrovirus group K member 6 Env polyprotein(ERVK-6),partial expressed in Yeast |
Results: When variants are classified by ACMG guidelines, misclassification was observed at 3.47% (2289 / 65,896) of variants. Overall suitability between HGMD and ClinVar is 97.62% (52,499 / 53,780) of the variants studied.
Conclusion: A variant in the database should be used with caution when variant pathogenicity interpreted. This study reveals misannotation frequency of variants and explanations HGMD compatibility between databases in depth.