Argentine Bioethics Association

Genetics and the human genome

Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans
Antibodies Assay Kits Bap1 Antibody Biology Cells Brd4 Antibody Canine Albumin cDNA Culture Cells Devices Glut2 Antibody Gsk3 Alpha Hama Antibodies Medium & Serums Muc2 Antibody NATtrol Nedd4 Antibody Nox1 Antibody PCR Reagents Recombinant Proteins Ria Kits RNA Tgf Alpha Elisa Vector & Virus Vi Alpha Vitronectin Antibody Western Blot Zebrafish Antibodies

Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans

For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there’s a convincing proof of affiliation in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the significance of inhabitants genetics and of sequencing knowledge within the design of genetic affiliation research in several human populations: the excessive linkage disequilibrium (LD) between rs2070788 and rs383510 is Asian-specific.
Leveraging on a mixture of genotyping and sequencing knowledge for Native Individuals (uncared for in genetic research), we present that whereas their frequencies of the Asian tag-SNP rs2070788 is, surprisingly, the best worldwide, it isn’t in LD with the eQTL rs383510, that subsequently, must be straight genotyped in genetic affiliation research of SARS in populations with Native American ancestry.

PRICKLE1 × FOCAD Interplay Revealed by Genome-Broad vQTL Evaluation of Human Facial Traits

The human face is a extremely advanced and variable construction ensuing from the intricate coordination of quite a few genetic and non-genetic elements. A whole bunch of genomic loci impacting quantitative facial options have been recognized.
Whereas these associations have been proven to affect morphology by altering the imply dimension and form of facial measures, their impact on trait variance stays unclear. We carried out a genome-wide affiliation evaluation for the variance of 20 quantitative facial measurements in 2,447 European people and recognized a number of suggestive variance quantitative trait loci (vQTLs).
These vQTLs guided us to conduct an environment friendly seek for gene-by-gene (G × G) interactions, which uncovered an interplay between PRICKLE1 and FOCAD affecting cranial base width. We replicated this G × G interplay sign on the locus stage in an extra 5,128 Korean people.
We used the hypomorphic Prickle1 Beetlejuice (Prickle1 Bj ) mouse line to straight take a look at the perform of Prickle1 on the cranial base and noticed wider cranial bases in Prickle1 Bj/Bj . Importantly, we noticed that the Prickle1 and Focadhesin proteins co-localize in murine cranial base chondrocytes, and this co-localization is irregular within the Prickle1 Bj/Bj mutants.
Taken collectively, our findings uncovered a novel G × G interplay impact in people with robust help from each epidemiological and molecular research. These outcomes spotlight the potential of finding out measures of phenotypic variability in gene mapping research of facial morphology.

Proof for opposing selective forces working on human-specific duplicated TCAF genes in Neanderthals and people

TRP channel-associated issue half (TCAF1/TCAF2) proteins antagonistically regulate the cold-sensor protein TRPM8 in a number of human tissues. Understanding their significance has been difficult given the locus spans a gap-ridden area with advanced segmental duplications in GRCh38. Utilizing long-read sequencing, we sequence-resolve the locus, annotate full-length TCAF fashions in primate genomes, and present substantial human-specific TCAF copy quantity variation.
We determine two human tremendous haplogroups, H4 and H5, and set up that TCAF duplications originated ~1.7 million years in the past however diversified solely in Homo sapiens by recurrent structural mutations. Conversely, in all archaic-hominin samples the fixation for a particular H4 haplotype with out duplication is probably going on account of constructive choice.
Right here, our outcomes of TCAF copy quantity enlargement, choice alerts in hominins, and differential TCAF2 expression between haplogroups and excessive TCAF2 and TRPM8 expression in liver and prostate in modern-day people suggest TCAF diversification amongst hominins doubtlessly in response to chilly or dietary diversifications.

A world map of associations between varieties of protein posttranslational modifications and human genetic ailments

There are >200 varieties of protein posttranslational modifications (PTMs) described in eukaryotes, every with distinctive proteome protection and capabilities. We hypothesized that some genetic ailments could also be attributable to the removing of a particular kind of PTMs by genomic variants and the resultant deregulation of explicit capabilities.
We collected >320,000 human PTMs representing 59 varieties and crossed them with >4M nonsynonymous DNA variants annotated with predicted pathogenicity and illness associations. We report >1.74M PTM-variant co-occurrences that an enrichment evaluation distributed into 215 pairwise associations between 18 PTM varieties and 148 genetic ailments.
Of them, 42% weren’t beforehand described. Elimination of lysine acetylation exerts probably the most pronounced impact, and fewer studied PTM varieties equivalent to S-glutathionylation or S-nitrosylation present relevance. Utilizing pathogenicity predictions, we recognized PTM websites that will produce explicit ailments if prevented. Our outcomes present proof of a considerable affect of PTM-specific removing on the pathogenesis of genetic ailments and phenotypes.

Human Codon Utilization: The Genetic Foundation of Pathogen Latency

Infectious ailments pose two important compelling points. First, the identification of the molecular elements that enable continual infections, that’s, the customarily fully asymptomatic coexistence of infectious brokers with the human host. Second, the definition of the mechanisms that enable the swap from pathogen dormancy to pathologic (re)activation.
Furthering earlier research, the current examine (1) analyzed the frequency of prevalence of synonymous codons in coding DNA, that’s, codon utilization, as a genetic device that guidelines protein expression; (2) described how human codon utilization can inhibit protein expression of infectious brokers throughout latency, in order that pathogen genes the codon utilization of which doesn’t conform to the human codon utilization can’t be translated; and (3) framed human codon utilization among the many front-line devices of the innate immunity towards infections.
In parallel, it was proven that, whereas genetics can account for the molecular foundation of pathogen latency, the modifications of the quantitative relationship between codon frequencies and isoaccepting tRNAs throughout cell proliferation supply a biochemical mechanism that explains the pathogen switching to (re)activation. Immunologically, this examine warns that utilizing codon optimization methodologies can (re)activate, potentiate, and immortalize in any other case quiescent, asymptomatic pathogens, thus resulting in uncontrollable pandemics.

Engineered human induced pluripotent cells allow genetic code enlargement in mind organoids

Human induced pluripotent stem cell (hiPSC) expertise has revolutionized human biology. A variety of cell varieties and tissue fashions will be derived from hiPSCs to review advanced human ailments. Right here, we use PiggyBac mediated transgenesis to engineer hiPSCs with an expanded genetic code. We reveal that genomic integration of expression cassettes for a pyrrolysyl-tRNA synthetase (PylRS), pyrrolysyl-tRNA (PylT) and the goal protein of curiosity permits site-specific incorporation of a non-canonical amino acid (ncAA) in response to amber cease codons.

West Nile Virus Envelope Peptide
3437P 0.05 mg
EUR 197.7
Description: (IN) West Nile Virus Envelope peptide

West Nile Virus Envelope Antibody
3439-002mg 0.02 mg
EUR 206.18
Description: West Nile Virus Envelope Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. While the viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway, the highly glycosylated envelope protein plays a major role for WNV entry into target cells as this entry can be inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.

West Nile Virus Envelope Antibody
3439-01mg 0.1 mg
EUR 523.7
Description: West Nile Virus Envelope Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. While the viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway, the highly glycosylated envelope protein plays a major role for WNV entry into target cells as this entry can be inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.

West Nile Virus Envelope Peptide
3439P 0.05 mg
EUR 197.7
Description: (NT) West Nile Virus Envelope peptide

West Nile Virus Envelope Antibody
3441-002mg 0.02 mg
EUR 206.18
Description: West Nile Virus Envelope Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. While the viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway, the highly glycosylated envelope protein plays a major role for WNV entry into target cells as this entry can be inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.

West Nile Virus Envelope Antibody
3441-01mg 0.1 mg
EUR 523.7
Description: West Nile Virus Envelope Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. While the viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway, the highly glycosylated envelope protein plays a major role for WNV entry into target cells as this entry can be inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.

West Nile Virus Envelope Peptide
3441P 0.05 mg
EUR 197.7
Description: (IN) West Nile Virus Envelope peptide

West Nile Virus Envelope Protein
abx060680-100ug 100 ug
EUR 794.4

West Nile Envelope Virus Protein
20-abx260322
  • EUR 1062.00
  • EUR 410.40
  • EUR 1930.80
  • 0.5 mg
  • 100 ug
  • 1 mg

West Nile Virus Envelope Recombinant Protein
53-361 0.01 mg
EUR 714.3
Description: West Nile Virus Envelope Recombinant Protein

West Nile Virus Envelope recombinant antigen
00401-V-01mg 0,1 mg
EUR 321
Description: West Nile Virus Envelope recombinant antigen-Immunodominant region

West Nile Virus Envelope recombinant antigen
00401-V-1000ug 1000 ug
EUR 1539
Description: West Nile Virus Envelope recombinant antigen-Immunodominant region

West Nile Virus Envelope Protein Antibody
abx022312-1mg 1 mg
EUR 1296

West Nile Virus Envelope Protein Antibody
abx022314-1mg 1 mg
EUR 1228.8

West Nile Virus Envelope Protein Antibody
abx022315-1mg 1 mg
EUR 1296

West Nile Virus Envelope Protein Antibody
abx022316-1mg 1 mg
EUR 1296

West Nile Virus Envelope recombinant antigen
8822 100 ug
EUR 529.8
Description: This is West Nile Virus Envelope recombinant antigen for ELISA,WB.

Polyclonal West Nile Virus Envelope Antibody
APR11226G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human West Nile Virus Envelope . This antibody is tested and proven to work in the following applications:

Polyclonal West Nile Virus Envelope Antibody
AMM05448G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human West Nile Virus Envelope . This antibody is tested and proven to work in the following applications:

Polyclonal West Nile Virus Envelope Antibody
AMM05449G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human West Nile Virus Envelope . This antibody is tested and proven to work in the following applications:

Recombinant West Nile Virus Envelope Protein
P1065-10 each
EUR 189.6

Recombinant West Nile Virus Envelope Protein
P1065-50 each
EUR 366

Mouse antibody for West Nile Virus Envelope
3655 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against West Nile Virus Envelope for WB, ELISA.

Mouse antibody for West Nile Virus Envelope
3661 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against West Nile Virus Envelope for WB, ELISA.

Mouse antibody for West Nile Virus Envelope
3671 100 ug
EUR 386.26
Description: This is purified Mouse monoclonal antibody against West Nile Virus Envelope for WB, ELISA.

West Nile virus antibody
10-1436 100 ug
EUR 489.6
Description: Mouse monoclonal West Nile virus antibody

West Nile virus antibody
10-1437 100 ug
EUR 489.6
Description: Mouse monoclonal West Nile virus antibody

Virus West Nile Virus (WNV) Protein
abx670276-100ug 100 ug
EUR 794.4

Native West Nile Virus antigen
DAGA-3052 1mg
EUR 1279.2

Native West Nile Virus antigen
DAGA-3053 1mg
EUR 1279.2

West Nile Virus Matrix Antibody
24278-100ul 100ul
EUR 468

West Nile Virus Matrix Antibody
24279-100ul 100ul
EUR 468

West Nile Virus Core Antibody
24281-100ul 100ul
EUR 468

West Nile Virus Matrix Antibody
3429-002mg 0.02 mg
EUR 206.18
Description: West Nile Virus Matrix Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside of infected cells, the matrix protein exists in its "pre-M" form as a heterodimer with the envelope proteins. Cleavage of the "pre-M" protein to its mature form occurs during release of the virus; this cleavage leas to the dissociation of the heterodimers. The WNV receptor has recently been identified as alpha v beta 3 integrin.

West Nile Virus Matrix Antibody
3429-01mg 0.1 mg
EUR 523.7
Description: West Nile Virus Matrix Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside of infected cells, the matrix protein exists in its "pre-M" form as a heterodimer with the envelope proteins. Cleavage of the "pre-M" protein to its mature form occurs during release of the virus; this cleavage leas to the dissociation of the heterodimers. The WNV receptor has recently been identified as alpha v beta 3 integrin.

West Nile Virus Matrix Peptide
3429P 0.05 mg
EUR 197.7
Description: (IN) West Nile Virus Matrix peptide

West Nile Virus Matrix Antibody
3431-002mg 0.02 mg
EUR 206.18
Description: West Nile Virus Matrix Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside of infected cells, the matrix protein exists in its "pre-M" form as a heterodimer with the envelope proteins. Cleavage of the "pre-M" protein to its mature form occurs during release of the virus; this cleavage leas to the dissociation of the heterodimers. The WNV receptor has recently been identified as alpha v beta 3 integrin.

West Nile Virus Matrix Antibody
3431-01mg 0.1 mg
EUR 523.7
Description: West Nile Virus Matrix Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside of infected cells, the matrix protein exists in its "pre-M" form as a heterodimer with the envelope proteins. Cleavage of the "pre-M" protein to its mature form occurs during release of the virus; this cleavage leas to the dissociation of the heterodimers. The WNV receptor has recently been identified as alpha v beta 3 integrin.

West Nile Virus Matrix Peptide
3431P 0.05 mg
EUR 197.7
Description: (CT) West Nile Virus Matrix peptide

West Nile Virus Core Antibody
3435-002mg 0.02 mg
EUR 206.18
Description: West Nile Virus Core Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.

West Nile Virus Core Antibody
3435-01mg 0.1 mg
EUR 523.7
Description: West Nile Virus Core Antibody: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins which play a major role for WNV entry into target cells. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.

West Nile Virus Core Peptide
3435P 0.05 mg
EUR 197.7
Description: (CT) West Nile Virus Core peptide

West Nile virus protein (Horse)
30-1261 250 ug
EUR 548.4
Description: Purified recombinant West Nile virus protein (Horse)

West Nile Virus (WNV) Antibody
abx412023-01mg 0.1 mg
EUR 610.8

West Nile Virus NS1 protein
80-1546 100 ug
EUR 541.2
Description: Purified Recombinant West Nile Virus NS1 protein (His tag)

West nile virus PCR kit
PCR-VH054-48R 50T
EUR 987.6

West nile virus PCR kit
PCR-VH054-96R 100T
EUR 1335.6

Recombinant West Nile Virus Envelope Protein (N-terminus), His-tagged
DAG566 100ug
EUR 786

Recombinant West Nile Virus WNV Envelope Protein, His, E.coli-100ug
QP13964-100ug 100ug
EUR 261.6

Recombinant West Nile Virus WNV Envelope Protein, His, E.coli-1mg
QP13964-1mg 1mg
EUR 1513.2

Recombinant West Nile Virus WNV Envelope Protein, His, E.coli-500ug
QP13964-500ug 500ug
EUR 795.6

Recombinant West Nile Pre-M Virus
7-07963 100µg Ask for price

Recombinant West Nile Pre-M Virus
7-07964 500µg Ask for price

Recombinant West Nile Pre-M Virus
7-07965 1000µg Ask for price

West Nile Virus ENV recombinant antigen
00403-V-01mg 0,1 mg
EUR 321
Description: West Nile Virus Envelope full length recombinant antigen 42 kDa region

West Nile Virus ENV recombinant antigen
00403-V-1000ug 1000 ug
EUR 1539
Description: West Nile Virus Envelope full length recombinant antigen 42 kDa region

West Nile Virus Core Protein Antibody
abx023202-100ug 100 ug
EUR 811.2

West Nile Virus Pre-M Protein
abx060681-100ug 100 ug
EUR 794.4

West Nile Pre-M Virus Protein
20-abx260323
  • EUR 1062.00
  • EUR 410.40
  • EUR 1930.80
  • 0.5 mg
  • 100 ug
  • 1 mg

Polyclonal West Nile Virus Matrix Antibody
APR11227G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human West Nile Virus Matrix . This antibody is tested and proven to work in the following applications:

Polyclonal West Nile Virus Core Antibody
AMM05447G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human West Nile Virus Core . This antibody is tested and proven to work in the following applications:

Polyclonal West Nile Virus Matrix Antibody
AMM05450G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human West Nile Virus Matrix . This antibody is tested and proven to work in the following applications:

West nile virus RT PCR kit
RTq-VH054-100R 100T
EUR 1573.2

West nile virus RT PCR kit
RTq-VH054-150R 150T
EUR 2144.4

West nile virus RT PCR kit
RTq-VH054-50R 50T
EUR 1155.6

QPCR Kit RNA West Nile virus
MOL6366 EACH
EUR 839.04

West Nile Virus Pre-M recombinant antigen
00402-V-01mg 0,1 mg
EUR 321
Description: West Nile Virus Pre-M recombinant antigen-Immunodominant region

West Nile Virus Pre-M recombinant antigen
00402-V-1000ug 1000 ug
EUR 1539
Description: West Nile Virus Pre-M recombinant antigen-Immunodominant region

West Nile Virus E protein (His tag)
80-1339 100 ug
EUR 289.2
Description: Purified recombinant West Nile Virus E protein (His tag)

West nile virus One-Step PCR kit
Oneq-VH054-100R 100T
EUR 1932

West nile virus One-Step PCR kit
Oneq-VH054-150R 150T
EUR 2646

West nile virus One-Step PCR kit
Oneq-VH054-50R 50T
EUR 1410

West Nile virus (WNV) Protein Detection Set
PSI-1809 1 Set
EUR 884.4
Description: West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside of infected cells, the matrix protein exists in its "pre-M" form as a heterodimer with the envelope proteins. Cleavage of the "pre-M” protein to its mature form occurs during release of the virus; this cleavage leads to the dissociation of the heterodimers. The viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway as delivery of core gene delivery into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation. The highly glycosylated envelope protein was shown to play a major role for WNV entry into target cells as WNV entry was inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin.;;For images please see PDF data sheet

Human West nile virus IgM (WNV-IgM) ELISA Kit
abx055291-96tests 96 tests
EUR 801.6

Human West nile virus IgG (WNV-IgG) ELISA Kit
abx055292-96tests 96 tests
EUR 801.6

Rabbit Anti-West Nile Virus (WNV) envelop protein antiserum
WNV16-S 100 ul
EUR 548.4

Rabbit Anti-West Nile Virus Env-DIII protein antiserum
WNVE19-S 100 ul
EUR 548.4

Rabbit Anti-West Nile Virus prM (WNV-prM) antiserum
WNVP21-S 100 ul
EUR 548.4

SeroDetect West Nile Virus Verification Panel (10 X 0.5 mL)
KZMC027 10 X 0.5 mL
EUR 334.56
Description: Please contact Gentaur in order to receive the datasheet of the product.

Rabbit Anti-West Nile Virus (WNV vaccine/Innovator, inactivated) antiserum
WNV12-S 100 ul
EUR 548.4

Rabbit Anti-West Nile Virus prm (WNV-prM) protein antiserum
WNV18-S 100 ul
EUR 548.4

Mouse Monoclonal Anti-West Nile Virus NS1 (WNV-NS1) IgG
WNVN20-M 100 ul
EUR 578.4

Recombinant (E. coli) West Nile N-terminus Envelope Virus (WNV) (E. Coli, >95%, 42 Kda, his-tag)
RP-1456 50 ug
EUR 343.2

Mouse Anti-West Nile Virus (whole virus) IgG ELISA kit, 2x96 tests, Quantitative
910-200-WNM 1 Kit
EUR 1951.2

Mouse Anti-West Nile Virus (whole virus) IgM ELISA kit, 2x96 tests, Quantitative
910-205-WNM 1 Kit
EUR 1000.8

Human Anti-West Nile Virus (whole virus) IgG ELISA kit, 96 tests, qualitative
910-400-WVG 1 Kit
EUR 854.4

Human Anti-West Nile Virus (whole virus) IgM ELISA kit, 96 tests, qualitative
910-405-WVG 1 Kit
EUR 854.4

Recombinant West Nile Virus Pre-M Protein (N-terminal), His-tagged
DAG584 100ug
EUR 786

ELISA kit for Human West Nile virus IgG (WNV IgG)  Kit
KTE62976-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgG (WNV IgG)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human West Nile virus IgG (WNV IgG)  Kit
KTE62976-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgG (WNV IgG)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human West Nile virus IgG (WNV IgG)  Kit
KTE62976-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgG (WNV IgG)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human West Nile virus IgM (WNV IgM)  Kit
KTE62977-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgM (WNV IgM)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human West Nile virus IgM (WNV IgM)  Kit
KTE62977-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgM (WNV IgM)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human West Nile virus IgM (WNV IgM)  Kit
KTE62977-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Human West Nile virus IgM (WNV IgM)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Recombinant West Nile Virus WNV Pre-M Protein, His, E.coli-100ug
QP13965-100ug 100ug
EUR 261.6

Recombinant West Nile Virus WNV Pre-M Protein, His, E.coli-1mg
QP13965-1mg 1mg
EUR 1513.2

Recombinant West Nile Virus WNV Pre-M Protein, His, E.coli-500ug
QP13965-500ug 500ug
EUR 795.6

Rabbit Anti-West Nile Virus vaccine (WNV, Recombitek/DNA vaccine) antiserum
WNV13-S 100 ul
EUR 548.4

Rabbit Anti-West Nile Virus NS1 (WNV-NS1, US strain) protein antiserum
WNV17-S 100 ul
EUR 548.4

Mouse Anti-West Nile Virus (WNV-whole virus) IgG ELISA kit, 2x96 tests, Semi-Quantitative
910-200-WNG 1 Kit
EUR 1951.2

Human Anti-West Nile Virus (WNV-whole virus) IgG ELISA kit, 96 tests, Semi-Quantitative
910-300-WNG 1 Kit
EUR 1000.8

Human Anti-West Nile Virus (WNV-whole virus) IgM ELISA kit, 96 tests, Semi-Quantitative
910-305-WNM 1 Kit
EUR 1000.8

Monkey Anti-West Nile Virus (WNV-whole virus) IgG ELISA kit, 2x96 tests, Semi-Quantitative
910-400-WNG 1 Kit
EUR 1951.2

Monkey Anti-West Nile Virus (WNV-whole virus) IgM ELISA kit, 2x96 tests, Semi-Quantitative
910-405-WNM 1 Kit
EUR 1951.2

West Nile Virus NS1 Protein (WNV-NS1) antigen ELISA kit, 96 tests, Quantitative
910-290-NS1 1 Kit
EUR 1000.8

Recombinant West Nile Virus (WNV) Pre-M Virus (E. Coli, ~20 Kda, >95%, his-tag) protein
RP-1457 50 ug
EUR 343.2

Zika virus envelope protein
30-1932 100 ug
EUR 457.2
Description: Recombinant Zika virus envelope protein

Zika virus envelope protein
30-1935 100 ug
EUR 289.2
Description: Recombinant Zika virus envelope protein

Zika virus envelope antibody
10-2712 1 mg
EUR 678
Description: Mouse monoclonal Zika virus envelope antibody

Zika virus envelope antibody
10-2713 1 mg
EUR 678
Description: Mouse monoclonal Zika virus envelope antibody

Zika virus envelope antibody
10-2714 1 mg
EUR 678
Description: Mouse monoclonal Zika virus envelope antibody

Zika virus envelope antibody
10-2715 1 mg
EUR 678
Description: Mouse monoclonal Zika virus envelope antibody

Zika Virus Envelope Protein
abx160022-1mg 1 mg
EUR 1746

Zika Virus Envelope Protein
abx061381-1mg 1 mg
EUR 1722

Chikungunya Virus Envelope Antibody
abx024072-1mg 1 mg
EUR 1161.6

Chikungunya Virus Envelope Antibody
abx024073-1mg 1 mg
EUR 1161.6

Chikungunya Virus Envelope Antibody
abx024074-1mg 1 mg
EUR 1161.6

Chikungunya Virus Envelope Antibody
abx024075-1mg 1 mg
EUR 1161.6

Chikungunya Virus Envelope Antibody
abx024076-1mg 1 mg
EUR 1161.6

Zika Virus Envelope Antibody
abx024128-1mg 1 mg
EUR 1730.4

Zika Virus Envelope Antibody
abx024129-1mg 1 mg
EUR 1730.4

Zika Virus Envelope Antibody
abx024130-1mg 1 mg
EUR 1730.4

Zika Virus Envelope Antibody
abx024131-1mg 1 mg
EUR 1730.4

Zika Virus Envelope Antibody
abx024132-1mg 1 mg
EUR 1696.8

Zika Virus Envelope Antibody
abx024133-1mg 1 mg
EUR 1696.8

NATtrol West Nile Virus (WNV) Strain: NY 2001-6263 (50,000 cp/mL) (1 mL)
NATWNV-0001 50,000 cp/mL 1 mL
EUR 103.68
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol West Nile Virus (WNV) Strain: NY 2001-6263 (500 cp/mL) (1 mL)
NATWNV-0002 500 cp/mL 1 mL
EUR 148.61
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol West Nile Virus (WNV) Strain: NY 2001-6263 (1,000 cp/mL) (1 mL)
NATWNV-0003 1,000 cp/mL 1 mL
EUR 213.5
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol West Nile Virus (WNV) Strain: NY 2001-6263 (10,000 cp/mL) (1 mL)
NATWNV-0004 10,000 cp/mL 1 mL
EUR 344.54
Description: Please contact Gentaur in order to receive the datasheet of the product.

NATtrol West Nile Virus (WNV) Strain: NY 2001-6263 (50,000 cp/mL) (1 mL)
NATWNV-0005 50,000 cp/mL 1 mL
EUR 549.22
Description: Please contact Gentaur in order to receive the datasheet of the product.

Recombinant (HEK) West Nile Virus NS1 (WNV-NS1) protein (>95%, ~50 Kda, His-tag)
WNVNS21-R-50 50 ug
EUR 489.6

West Nile Virus (WNV) (Strain: NY 2001-6263) Culture Fluid (Heat Inactivated) (1 mL)
0810033CFHI -
EUR 422

West Nile Virus (WNV) Lineage 2 (Strain: 1986) Culture Fluid (Heat Inactivated) (1 mL)
0810082CFHI -
EUR 422
Neural stem cells, neurons and mind organoids derived from the engineered hiPSCs proceed to precise the amber suppression equipment and produce ncAA-bearing reporter. The integrated ncAA can function a minimal bioorthogonal deal with for additional modifications by labeling with fluorescent dyes. Website-directed ncAA mutagenesis will open a variety of functions to probe and manipulate proteins in mind organoids and different hiPSC-derived cell varieties and complicated tissue fashions.
Tags:
MicroRNAs in Genetic Etiology of Human Diseases

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