Impacts of genomic networks governed by human-specific regulatory sequences and genetic loci harboring fixed human-specific neuro-regulatory single nucleotide mutations on phenotypic traits of modern humans

Impacts of genomic networks governed by human-specific regulatory sequences and genetic loci harboring fixed human-specific neuro-regulatory single nucleotide mutations on phenotypic traits of modern humans

recent advances in the identification and characterization of the human DNA sequence-specific regulation set the stage for a global assessment of their impact on the physiology and pathology of modern humans. Gene set enrichment analysis (GSEA) on 8405 35 074 human genes associated with neuro-regulatory-specific single nucleotide changes (hsSNCs) revealed numerous significant association with morphological structure, physiological processes and pathological conditions of modern man.

Significantly enhanced properties including more than 1000 different anatomical regions of the adult human brain, different types of cells and tissues, more than 200 human disorders are common, and more than 1000 records of rare diseases. HsSNCs thousands of genes connected with neuro-regulation have been identified, which represent an important genetic elements of autosomal inheritance and child survival phenotype. A total of 1,494 hsSNC-linked genes associated with either autosomal dominant or recessive, and 2273 genes related hsSNC has been linked to premature death, lethal embryos, as well as pre, peri, neo, and post-natal lethal phenotype of both complete and incomplete penetration.

Differential GSEA implemented on hsSNC-linked loci and genes associated to identify a set of 7990 hsSNC-target gene linked to a different class the evolution of human-specific regulatory sequence (hypersensitivity reaction). In particular, the expression of the majority of these genes (genes 5389; 67%) set by the sequence of stem cell-related retroviral (scar) and scar-regulated genes were arrested dominant fraction (91%) of the association of phenotype that was significantly associated with hsSNCs. MGI interrogation of databases revealed mouse models are available tailored to the exact experimental definition of the functional effects hsSNCs and scars on the causal genes that affect the phenotype of thousands of mammals and human beings are involved in hundreds of common and rare disorders.

These observations indicate that the dominant nature of certain men thrive under regulatory control combinations of different classes of a HSR and neuro-regulatory hsSNCs locus storing fixed in humans, is different from other primates, and is located in the region of chromatin vary accessed during brain development ,

 Impacts of genomic networks governed by human-specific regulatory sequences and genetic loci harboring fixed human-specific neuro-regulatory single nucleotide mutations on phenotypic traits of modern humans
Impacts of genomic networks governed by human-specific regulatory sequences and genetic loci harboring fixed human-specific neuro-regulatory single nucleotide mutations on phenotypic traits of modern humans

Genetic Diversity of Human Immunodeficiency Virus Type 1 in asymptomatic blood donors in Islamabad, Pakistan

The goal serological testing for human immunodeficiency virus (HIV) is mandatory under the security laws in the blood of Pakistan; Therefore, the existing data on the prevalence of HIV in the blood donor. However, little is known about the molecular epidemiology of HIV in the blood donor population.

Therefore, this study was designed to study the genetic diversity of HIV-1 infection in treatment-naïve population of apparently healthy blood donors in Islamabad, Pakistan. Materials and Methods A total of 85 736 blood donors tested for HIV by chemiluminescence immunoassay. All samples were positive donor were analyzed for the presence of various HIV genotypes (types and subtypes). viral ribonucleic acid extracted from blood samples from HIV-positive donors and reverse transcribed into a complementary deoxyribonucleic acid (cDNA).

Recombinant Human rhinovirus 2 Genome polyprotein

MBS1030888-01mgEColi 0.1mg(E-Coli)
EUR 1030

Recombinant Human rhinovirus 2 Genome polyprotein

MBS1030888-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-01mgEColi 0.1mg(E-Coli)
EUR 1035

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-002mgEColi 0.02mg(E-Coli)
EUR 855

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-01mgEColi 0.1mg(E-Coli)
EUR 1030

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-01mgYeast 0.1mg(Yeast)
EUR 1130

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1125

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-005mgEColi 0.05mg(E-Coli)
EUR 860

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-005mgYeast 0.05mg(Yeast)
EUR 995

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-02mgEColi 0.2mg(E-Coli)
EUR 1120

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-05mgEColi 0.5mg(E-Coli)
EUR 1225

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1120

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-005mgEColi 0.05mg(E-Coli)
EUR 860

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-005mgYeast 0.05mg(Yeast)
EUR 995

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-02mgEColi 0.2mg(E-Coli)
EUR 1120

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-05mgEColi 0.5mg(E-Coli)
EUR 1225

Recombinant Human rhinovirus 1A Genome polyprotein VP1

MBS9422616-002mg 0.02mg
EUR 320

Recombinant Human rhinovirus 1A Genome polyprotein VP1

MBS9422616-01mg 0.1mg
EUR 540

Recombinant Human rhinovirus 1A Genome polyprotein VP1

MBS9422616-05mg 0.5mg
EUR 1360

Recombinant Human rhinovirus 1A Genome polyprotein VP1

MBS9422616-5x05mg 5x0.5mg
EUR 5965

Human rhinovirus A serotype 89 Genome polyprotein

1-CSB-YP362073HQD
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in Yeast

Human rhinovirus A serotype 89 Genome polyprotein

1-CSB-EP362073HQD
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli

Human rhinovirus A serotype 89 Genome polyprotein

1-CSB-EP362073HQDb0
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli

Recombinant Human rhinovirus 1A Genome polyprotein, partial

CSB-YP326367HQA 6222 mg Ask for price

Recombinant Human rhinovirus 1A Genome polyprotein,partial

AP72911 each Ask for price

Recombinant Human rhinovirus 1A Genome polyprotein, partial

CSB-EP326367HQA 11613 mg Ask for price

Recombinant Human rhinovirus 1B Genome polyprotein, partial

CSB-EP320160HQB 10401 mg Ask for price

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-002mgEColi 0.02mg(E-Coli)
EUR 375

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-002mgYeast 0.02mg(Yeast)
EUR 275

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-01mgEColi 0.1mg(E-Coli)
EUR 640

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-01mgYeast 0.1mg(Yeast)
EUR 450

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-05mgYeast 0.5mg(Yeast)
EUR 1065

Recombinant Human rhinovirus 1A Genome polyprotein,partial

RPC25135-100ug 100ug
EUR 573.1

Recombinant Human rhinovirus 1A Genome polyprotein,partial

RPC25135-20ug 20ug
EUR 288.8

Recombinant Human rhinovirus A serotype 89 Genome polyprotein

MBS9422687-002mg 0.02mg
EUR 320

Recombinant Human rhinovirus A serotype 89 Genome polyprotein

MBS9422687-01mg 0.1mg
EUR 540

Recombinant Human rhinovirus A serotype 89 Genome polyprotein

MBS9422687-05mg 0.5mg
EUR 1360

Recombinant Human rhinovirus A serotype 89 Genome polyprotein

MBS9422687-5x05mg 5x0.5mg
EUR 5965

Rhinovirus A serotype 89 Genome polyprotein Antibody

20-abx109372
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Rhinovirus A serotype 89 Genome polyprotein Antibody

abx109372-100l 100 µl
EUR 162.5

Recombinant Human rhinovirus A serotype 89 Genome polyprotein VP1

MBS1245807-002mgEColi 0.02mg(E-Coli)
EUR 255

Recombinant Human rhinovirus A serotype 89 Genome polyprotein VP1

MBS1245807-002mgYeast 0.02mg(Yeast)
EUR 270

Recombinant Human rhinovirus A serotype 89 Genome polyprotein VP1

MBS1245807-01mgEColi 0.1mg(E-Coli)
EUR 405

Recombinant Human rhinovirus A serotype 89 Genome polyprotein VP1

MBS1245807-01mgYeast 0.1mg(Yeast)
EUR 450

Recombinant Human rhinovirus A serotype 89 Genome polyprotein VP1

MBS1245807-05mgYeast 0.5mg(Yeast)
EUR 1065

Recombinant Human rhinovirus A serotype 89 Genome polyprotein VP1

MBS9421040-002mg 0.02mg
EUR 285

Recombinant Human rhinovirus A serotype 89 Genome polyprotein VP1

MBS9421040-01mg 0.1mg
EUR 470

Recombinant Human rhinovirus A serotype 89 Genome polyprotein VP1

MBS9421040-1mg 1mg
EUR 1785

Recombinant Human rhinovirus A serotype 89 Genome polyprotein VP1

MBS9421040-5x1mg 5x1mg
EUR 7885

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial

CSB-YP362073HQD 6387 mg Ask for price

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

AP71163 1mg
EUR 1978

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

AP72984 each Ask for price

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

AP77542 1mg
EUR 1978

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial

CSB-EP362073HQD 3389 mg Ask for price

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial

CSB-EP362073HQDb0 3390 mg Ask for price

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

RPC22779-100ug 100ug
EUR 460.9

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

RPC22779-1mg 1mg
EUR 2237.8

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

RPC22779-20ug 20ug
EUR 258.7

Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP)

20-abx108723
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Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP)

abx108723-100g 100 µg
EUR 362.5

Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP)

abx108723-20g 20 µg
EUR 162.5

Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP)

abx108723-50g 50 µg
EUR 250

Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC)

20-abx107303
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Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC)

abx107303-100g 100 µg
EUR 362.5

Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC)

abx107303-20g 20 µg
EUR 162.5

Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC)

abx107303-50g 50 µg
EUR 250

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial, Biotinylated

CSB-EP362073HQD-B 7058 mg Ask for price

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial,Biotinylated

RPC27677-100ug 100ug
EUR 614.3

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial,Biotinylated

RPC27677-1mg 1mg
EUR 2373.6

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial,Biotinylated

RPC27677-20ug 20ug
EUR 468

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial, Biotinylated

MBS7137014-002mgEColi 0.02mg(E-Coli)
EUR 255

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial, Biotinylated

MBS7137014-01mgEColi 0.1mg(E-Coli)
EUR 405

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial, Biotinylated

MBS7137014-1mgEColi 1mg(E-Coli)
EUR 1425

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial, Biotinylated

MBS7137014-5x1mgEColi 5x1mg(E-Coli)
EUR 6215

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody

MBS1493993-005mg 0.05mg
EUR 190

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody

MBS1493993-01mg 0.1mg
EUR 270

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody

MBS1493993-5x01mg 5x0.1mg
EUR 1205

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody, FITC

MBS1492262-005mg 0.05mg
EUR 190

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody, FITC

MBS1492262-01mg 0.1mg
EUR 270

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody, FITC

MBS1492262-5x01mg 5x0.1mg
EUR 1205

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody, HRP conjugated

MBS1492051-005mg 0.05mg
EUR 190

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody, HRP conjugated

MBS1492051-01mg 0.1mg
EUR 270

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody, HRP conjugated

MBS1492051-5x01mg 5x0.1mg
EUR 1205

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody, Biotin conjugated

MBS1496260-005mg 0.05mg
EUR 190

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody, Biotin conjugated

MBS1496260-01mg 0.1mg
EUR 270

Rabbit anti-Human rhinovirus A serotype 89 Genome polyprotein polyclonal Antibody, Biotin conjugated

MBS1496260-5x01mg 5x0.1mg
EUR 1205

Recombinant human Genome polyprotein

MBS960928-005mg 0.05mg
EUR 695

Recombinant human Genome polyprotein

MBS960928-02mg 0.2mg
EUR 905

Recombinant human Genome polyprotein

MBS960928-05mg 0.5mg
EUR 990

Recombinant human Genome polyprotein

MBS960928-1mg 1mg
EUR 1355

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1170

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-002mgEColi 0.02mg(E-Coli)
EUR 810

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-002mgYeast 0.02mg(Yeast)
EUR 960

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-01mgEColi 0.1mg(E-Coli)
EUR 970

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-01mgYeast 0.1mg(Yeast)
EUR 1125

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1120

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-005mgEColi 0.05mg(E-Coli)
EUR 810

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-005mgYeast 0.05mg(Yeast)
EUR 960

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-02mgEColi 0.2mg(E-Coli)
EUR 1080

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-05mgEColi 0.5mg(E-Coli)
EUR 1155

Equine Rhinitis A Virus Genome Polyprotein Antibody

abx345840-100g 100 µg Ask for price

Equine Rhinitis A Virus Genome Polyprotein Antibody

abx345840-20g 20 µg
EUR 250

Equine Rhinitis A Virus Genome Polyprotein Antibody

abx345840-50g 50 µg
EUR 350

Recombinant Human Genome polyprotein, His-SUMO, E.coli-10ug

QP7370-ec-10ug 10ug
EUR 240

Recombinant Human Genome polyprotein, His-SUMO, E.coli-50ug

QP7370-ec-50ug 50ug
EUR 315.6

Recombinant Human Genome polyprotein, His-SUMO, E.coli-1mg

QP7370-ec-1mg 1mg
EUR 1958.4

Recombinant Human Genome polyprotein, His-SUMO, E.coli-100ug

QP7370-ec-100ug 100ug
EUR 489.6

Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug

QP7370-ec-200ug 200ug
EUR 760.8

Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug

QP7370-ec-500ug 500ug
EUR 1272

Genome Polyprotein Antibody

20-abx109417
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  • 100 ug
  • 1 mg
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Genome polyprotein Antibody

20-abx300967
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Genome polyprotein Antibody

1-CSB-PA18549A0Rb
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA333180LA01HFD
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA362073LA01HQD
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

CSB-PA4643XA11GSV 100ul / 50ul
EUR 299
Description: Genome polyprotein

Genome polyprotein Antibody

CSB-PA4644XA11GSW 100ul / 50ul
EUR 299
Description: Genome polyprotein

Genome polyprotein Antibody

1-CSB-PA714772LA01HYH
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

abx300967-100g 100 µg
EUR 362.5

Genome polyprotein Antibody

abx300967-20g 20 µg
EUR 162.5

Genome polyprotein Antibody

abx300967-50g 50 µg
EUR 250

Genome Polyprotein Antibody

abx109417-100l 100 µl
EUR 162.5

Genome polyprotein Antibody

MBS7147310-INQUIRE INQUIRE Ask for price

Genome polyprotein Antibody

MBS7149174-INQUIRE INQUIRE Ask for price

Genome polyprotein Antibody

MBS7152538-INQUIRE INQUIRE Ask for price

Genome polyprotein Antibody

MBS7152900-INQUIRE INQUIRE Ask for price

Genome polyprotein Antibody

MBS7153436-INQUIRE INQUIRE Ask for price

Genome polyprotein Antibody

MBS7153583-INQUIRE INQUIRE Ask for price

Genome polyprotein Antibody

MBS7150431-005mL 0.05mL
EUR 190

Genome polyprotein Antibody

MBS7150431-01mL 0.1mL
EUR 270

Genome polyprotein Antibody

MBS7150431-5x01mL 5x0.1mL
EUR 1205

Genome polyprotein Antibody

MBS7165482-INQUIRE INQUIRE Ask for price

Genome polyprotein Antibody

MBS9004166-INQUIRE INQUIRE Ask for price

Genome polyprotein Antibody

MBS9000495-INQUIRE INQUIRE Ask for price

Recombinant Genome polyprotein

MBS1141323-005mgBaculovirus 0.05mg(Baculovirus)
EUR 875

Recombinant Genome polyprotein

MBS1141323-005mgEColi 0.05mg(E-Coli)
EUR 490

Recombinant Genome polyprotein

MBS1141323-005mgYeast 0.05mg(Yeast)
EUR 690

Recombinant Genome polyprotein

MBS1141323-02mgEColi 0.2mg(E-Coli)
EUR 640

Recombinant Genome polyprotein

MBS1141323-05mgEColi 0.5mg(E-Coli)
EUR 695

Recombinant Genome polyprotein

MBS1068339-002mgBaculovirus 0.02mg(Baculovirus)
EUR 990

Recombinant Genome polyprotein

MBS1068339-002mgEColi 0.02mg(E-Coli)
EUR 555

Recombinant Genome polyprotein

MBS1068339-002mgYeast 0.02mg(Yeast)
EUR 745

Recombinant Genome polyprotein

MBS1068339-01mgEColi 0.1mg(E-Coli)
EUR 665

Recombinant Genome polyprotein

MBS1068339-01mgYeast 0.1mg(Yeast)
EUR 870

Recombinant Genome polyprotein

MBS1257473-002mgBaculovirus 0.02mg(Baculovirus)
EUR 990

Recombinant Genome polyprotein

MBS1257473-002mgEColi 0.02mg(E-Coli)
EUR 555

Recombinant Genome polyprotein

MBS1257473-002mgYeast 0.02mg(Yeast)
EUR 745

The cDNA of all positive donor were then analyzed for the presence of various HIV genotypes (types and subtypes) using the primer specific subtype in a nested polymerase chain reaction. Products powered run on ethidium bromide-stained 2% agarose gel and visualized using ultraviolet Transilluminator. A particular subtype is assigned to a specific subtype samples if the reaction made the band a very intense 20% compared to the band made by subtype-independent reaction.

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