The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review

The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review

Background: The vulnerability to a severe viral infection reported to be associated with genetic variants in immune response genes using case reports and studies GWAS. SARS-CoV-2 is a viral disease that appears that caused millions of COVID 19 cases worldwide. Approximately 15% of severe cases and some of them are accompanied by an immune system that is not regulated and the cytokine storm. There is increasing evidence that severe manifestations COVID-19 may be associated with human genetic variants in genes associated with immune deficiency and or inflammasome activation (cytokine storm).
Objective: Identification of candidate genes that may be helpful in explaining the severe COVID-19 and provide insight to understand COVID-19 is severe.

Methods: In this article, we systematically genes associated with susceptibility virus reported in human genetic studies (GWAS case reports) to understand the role of the host virus interactions and to provide insight into the pathogenesis of severe COVID 19th.

Results: We found 40 genes associated with susceptibility virus and 21 of them were related to SARS-CoV-severe and 19 severe COVID. Some of those genes involved in TLR pathways, other people in line C-lectins, and others associated with inflammasome activation (cytokine storm).

Conclusion: This compilation is a list of candidate genes that may be helpful in explaining the proper COVID-19 gene panel and included in the meta-analysis for different variants in genetic studies of a number of severe COVID 19th. In addition, we provide several hypotheses for the 19th COVID severe and possible therapeutic targets.

 The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review
The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review

Evidence for non-genetic inheritance of germline human phenotype and disease

It is becoming increasingly clear that certain inherited across generations phenotype independent of the information contained in the DNA sequence, by factors in the germ cells remain largely uncharacterized. As evidence for the inheritance of non-germline genetic phenotype and disease continues to evolve in a model organism, there are fewer reports of this phenomenon in humans, because of various complications in evaluating the legacy of this mechanism in humans. This review summarizes evidence-based legacy non-germline genetic in humans, as well as significant challenges and important warnings that should be considered when evaluating this process in the human population.

Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug

QP7370-ec-500ug 500ug
EUR 1272

Recombinant Human Genome polyprotein, His-SUMO, E.coli-1mg

QP7370-ec-1mg 1mg
EUR 1958.4

Recombinant Human Genome polyprotein, His, Yeast-10ug

QP7370-ye-10ug 10ug
EUR 283.2

Recombinant Human Genome polyprotein, His, Yeast-1mg

QP7370-ye-1mg 1mg
EUR 2262

Recombinant Human Genome polyprotein, His, Yeast-50ug

QP7370-ye-50ug 50ug
EUR 358.8

Recombinant Human Genome polyprotein, His, Yeast-100ug

QP7370-ye-100ug 100ug
EUR 576

Recombinant Human Genome polyprotein, His, Yeast-200ug

QP7370-ye-200ug 200ug
EUR 892.8

Recombinant Human Genome polyprotein, His, Yeast-500ug

QP7370-ye-500ug 500ug
EUR 1447.2

Recombinant human Genome polyprotein

MBS960928-005mg 0.05mg
EUR 695

Recombinant human Genome polyprotein

MBS960928-02mg 0.2mg
EUR 905

Recombinant human Genome polyprotein

MBS960928-05mg 0.5mg
EUR 990

Recombinant human Genome polyprotein

MBS960928-1mg 1mg
EUR 1355

Recombinant Genome polyprotein

MBS1141323-005mgBaculovirus 0.05mg(Baculovirus)
EUR 875

Recombinant Genome polyprotein

MBS1141323-005mgEColi 0.05mg(E-Coli)
EUR 490

Recombinant Genome polyprotein

MBS1141323-005mgYeast 0.05mg(Yeast)
EUR 690

Recombinant Genome polyprotein

MBS1141323-02mgEColi 0.2mg(E-Coli)
EUR 640

Recombinant Genome polyprotein

MBS1141323-05mgEColi 0.5mg(E-Coli)
EUR 695

Recombinant Genome polyprotein

MBS1068339-002mgBaculovirus 0.02mg(Baculovirus)
EUR 990

Recombinant Genome polyprotein

MBS1068339-002mgEColi 0.02mg(E-Coli)
EUR 555

Recombinant Genome polyprotein

MBS1068339-002mgYeast 0.02mg(Yeast)
EUR 745

Recombinant Genome polyprotein

MBS1068339-01mgEColi 0.1mg(E-Coli)
EUR 665

Recombinant Genome polyprotein

MBS1068339-01mgYeast 0.1mg(Yeast)
EUR 870

Recombinant Genome polyprotein

MBS1257473-002mgBaculovirus 0.02mg(Baculovirus)
EUR 990

Recombinant Genome polyprotein

MBS1257473-002mgEColi 0.02mg(E-Coli)
EUR 555

Recombinant Genome polyprotein

MBS1257473-002mgYeast 0.02mg(Yeast)
EUR 745

Recombinant Genome polyprotein

MBS1257473-01mgEColi 0.1mg(E-Coli)
EUR 665

Recombinant Genome polyprotein

MBS1257473-01mgYeast 0.1mg(Yeast)
EUR 870

Recombinant Genome polyprotein

MBS1236293-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1045

Recombinant Genome polyprotein

MBS1236293-002mgEColi 0.02mg(E-Coli)
EUR 625

Recombinant Genome polyprotein

MBS1236293-002mgYeast 0.02mg(Yeast)
EUR 800

Recombinant Genome polyprotein

MBS1236293-01mgEColi 0.1mg(E-Coli)
EUR 725

Recombinant Genome polyprotein

MBS1236293-01mgYeast 0.1mg(Yeast)
EUR 935

Recombinant Genome polyprotein

MBS1040920-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1045

Recombinant Genome polyprotein

MBS1040920-002mgEColi 0.02mg(E-Coli)
EUR 620

Recombinant Genome polyprotein

MBS1040920-002mgYeast 0.02mg(Yeast)
EUR 795

Recombinant Genome polyprotein

MBS1040920-01mgEColi 0.1mg(E-Coli)
EUR 720

Recombinant Genome polyprotein

MBS1040920-01mgYeast 0.1mg(Yeast)
EUR 930

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-01mgEColi 0.1mg(E-Coli)
EUR 1035

Recombinant Human rhinovirus 14 Genome polyprotein

MBS1158398-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Human rhinovirus 2 Genome polyprotein

MBS1030888-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Human rhinovirus 2 Genome polyprotein

MBS1030888-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Human rhinovirus 2 Genome polyprotein

MBS1030888-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Human rhinovirus 2 Genome polyprotein

MBS1030888-01mgEColi 0.1mg(E-Coli)
EUR 1030

Recombinant Human rhinovirus 2 Genome polyprotein

MBS1030888-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-002mgEColi 0.02mg(E-Coli)
EUR 855

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-01mgEColi 0.1mg(E-Coli)
EUR 1030

Recombinant Human rhinovirus 1B Genome polyprotein

MBS1154102-01mgYeast 0.1mg(Yeast)
EUR 1130

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1125

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-005mgEColi 0.05mg(E-Coli)
EUR 860

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-005mgYeast 0.05mg(Yeast)
EUR 995

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-02mgEColi 0.2mg(E-Coli)
EUR 1120

Recombinant Human rhinovirus 3 Genome polyprotein

MBS1326793-05mgEColi 0.5mg(E-Coli)
EUR 1225

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1120

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-005mgEColi 0.05mg(E-Coli)
EUR 860

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-005mgYeast 0.05mg(Yeast)
EUR 995

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-02mgEColi 0.2mg(E-Coli)
EUR 1120

Recombinant Human rhinovirus 16 Genome polyprotein

MBS1325019-05mgEColi 0.5mg(E-Coli)
EUR 1225

Recombinant Human enterovirus 70 Genome polyprotein

MBS1260910-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1195

Recombinant Human enterovirus 70 Genome polyprotein

MBS1260910-002mgEColi 0.02mg(E-Coli)
EUR 845

Recombinant Human enterovirus 70 Genome polyprotein

MBS1260910-002mgYeast 0.02mg(Yeast)
EUR 985

Recombinant Human enterovirus 70 Genome polyprotein

MBS1260910-01mgEColi 0.1mg(E-Coli)
EUR 1015

Recombinant Human enterovirus 70 Genome polyprotein

MBS1260910-01mgYeast 0.1mg(Yeast)
EUR 1120

Recombinant Human enterovirus 71 Genome polyprotein

MBS1327007-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1200

Recombinant Human enterovirus 71 Genome polyprotein

MBS1327007-002mgEColi 0.02mg(E-Coli)
EUR 850

Recombinant Human enterovirus 71 Genome polyprotein

MBS1327007-002mgYeast 0.02mg(Yeast)
EUR 990

Recombinant Human enterovirus 71 Genome polyprotein

MBS1327007-01mgEColi 0.1mg(E-Coli)
EUR 1020

Recombinant Human enterovirus 71 Genome polyprotein

MBS1327007-01mgYeast 0.1mg(Yeast)
EUR 1125

Recombinant Human enterovirus 71 Genome polyprotein

MBS1427939-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1200

Recombinant Human enterovirus 71 Genome polyprotein

MBS1427939-002mgEColi 0.02mg(E-Coli)
EUR 850

Recombinant Human enterovirus 71 Genome polyprotein

MBS1427939-002mgYeast 0.02mg(Yeast)
EUR 990

Recombinant Human enterovirus 71 Genome polyprotein

MBS1427939-01mgEColi 0.1mg(E-Coli)
EUR 1020

Recombinant Human enterovirus 71 Genome polyprotein

MBS1427939-01mgYeast 0.1mg(Yeast)
EUR 1125

Recombinant Human parechovirus 1 Genome polyprotein

CSB-YP734409HCAV 9748 mg Ask for price

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1170

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-002mgEColi 0.02mg(E-Coli)
EUR 810

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-002mgYeast 0.02mg(Yeast)
EUR 960

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-01mgEColi 0.1mg(E-Coli)
EUR 970

Recombinant Human parechovirus 2 Genome polyprotein

MBS1055056-01mgYeast 0.1mg(Yeast)
EUR 1125

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1120

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-005mgEColi 0.05mg(E-Coli)
EUR 810

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-005mgYeast 0.05mg(Yeast)
EUR 960

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-02mgEColi 0.2mg(E-Coli)
EUR 1080

Recombinant Human parechovirus 2 Genome polyprotein

MBS1453047-05mgEColi 0.5mg(E-Coli)
EUR 1155

Recombinant Human parechovirus 1 Genome polyprotein

MBS1414957-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1170

Recombinant Human parechovirus 1 Genome polyprotein

MBS1414957-002mgEColi 0.02mg(E-Coli)
EUR 810

Recombinant Human parechovirus 1 Genome polyprotein

MBS1414957-002mgYeast 0.02mg(Yeast)
EUR 960

Recombinant Human parechovirus 1 Genome polyprotein

MBS1414957-01mgEColi 0.1mg(E-Coli)
EUR 970

Recombinant Human parechovirus 1 Genome polyprotein

MBS1414957-01mgYeast 0.1mg(Yeast)
EUR 1125

Recombinant Genome polyprotein, partial

MBS1014881-INQUIRE INQUIRE Ask for price

Recombinant Genome polyprotein, partial

MBS1088414-INQUIRE INQUIRE Ask for price

Recombinant Human rhinovirus 1A Genome polyprotein VP1

MBS9422616-002mg 0.02mg
EUR 320

Recombinant Human rhinovirus 1A Genome polyprotein VP1

MBS9422616-01mg 0.1mg
EUR 540

Recombinant Human rhinovirus 1A Genome polyprotein VP1

MBS9422616-05mg 0.5mg
EUR 1360

Recombinant Human rhinovirus 1A Genome polyprotein VP1

MBS9422616-5x05mg 5x0.5mg
EUR 5965

Recombinant Human rhinovirus 1A Genome polyprotein, partial

CSB-YP326367HQA 6222 mg Ask for price

Recombinant Human rhinovirus 1A Genome polyprotein,partial

AP72911 each Ask for price

Recombinant Human rhinovirus 1A Genome polyprotein, partial

CSB-EP326367HQA 11613 mg Ask for price

Recombinant Human rhinovirus 1B Genome polyprotein, partial

CSB-EP320160HQB 10401 mg Ask for price

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-002mgEColi 0.02mg(E-Coli)
EUR 375

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-002mgYeast 0.02mg(Yeast)
EUR 275

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-01mgEColi 0.1mg(E-Coli)
EUR 640

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-01mgYeast 0.1mg(Yeast)
EUR 450

Recombinant Human rhinovirus 1A Genome polyprotein, partial

MBS1220686-05mgYeast 0.5mg(Yeast)
EUR 1065

Recombinant Human rhinovirus 1A Genome polyprotein,partial

RPC25135-100ug 100ug
EUR 573.1

Recombinant Human rhinovirus 1A Genome polyprotein,partial

RPC25135-20ug 20ug
EUR 288.8

Recombinant Human parechovirus 2 Genome polyprotein, partial

CSB-EP529147HXJ 9583 mg Ask for price

Recombinant Human parechovirus 1 Genome polyprotein, partial

CSB-EP734409HCAV 9651 mg Ask for price

Recombinant Hepatitis C Genome polyprotein

CSB-RP184674Ba 5430 mg Ask for price

Recombinant Echovirus 11 Genome polyprotein

MBS1164799-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Echovirus 11 Genome polyprotein

MBS1164799-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Echovirus 11 Genome polyprotein

MBS1164799-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Echovirus 11 Genome polyprotein

MBS1164799-01mgEColi 0.1mg(E-Coli)
EUR 1035

Recombinant Echovirus 11 Genome polyprotein

MBS1164799-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Langat virus Genome polyprotein

MBS1133753-INQUIRE INQUIRE Ask for price

Recombinant Echovirus 12 Genome polyprotein

MBS1285198-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Echovirus 12 Genome polyprotein

MBS1285198-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Echovirus 12 Genome polyprotein

MBS1285198-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Echovirus 12 Genome polyprotein

MBS1285198-01mgEColi 0.1mg(E-Coli)
EUR 1030

Recombinant Echovirus 12 Genome polyprotein

MBS1285198-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Hepatitis C Genome polyprotein

RPC24458-100ug 100ug
EUR 721.6

Recombinant Hepatitis C Genome polyprotein

RPC24458-20ug 20ug
EUR 448.1

Recombinant Echovirus 1 Genome polyprotein

MBS1036392-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Echovirus 1 Genome polyprotein

MBS1036392-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Echovirus 1 Genome polyprotein

MBS1036392-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Echovirus 1 Genome polyprotein

MBS1036392-01mgEColi 0.1mg(E-Coli)
EUR 1030

Recombinant Echovirus 1 Genome polyprotein

MBS1036392-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Langat virus Genome polyprotein

MBS7038287-002mg 0.02mg
EUR 1845

Recombinant Langat virus Genome polyprotein

MBS7038287-01mg 0.1mg
EUR 2775

Recombinant Langat virus Genome polyprotein

MBS7038287-5x01mg 5x0.1mg
EUR 12450

Recombinant Echovirus 16 Genome polyprotein

MBS1346831-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Echovirus 16 Genome polyprotein

MBS1346831-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Echovirus 16 Genome polyprotein

MBS1346831-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Echovirus 16 Genome polyprotein

MBS1346831-01mgEColi 0.1mg(E-Coli)
EUR 1035

Recombinant Echovirus 16 Genome polyprotein

MBS1346831-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Echovirus 30 Genome polyprotein

MBS1479634-005mgBaculovirus 0.05mg(Baculovirus)
EUR 1120

Recombinant Echovirus 30 Genome polyprotein

MBS1479634-005mgEColi 0.05mg(E-Coli)
EUR 860

Recombinant Echovirus 30 Genome polyprotein

MBS1479634-005mgYeast 0.05mg(Yeast)
EUR 995

Recombinant Echovirus 30 Genome polyprotein

MBS1479634-02mgEColi 0.2mg(E-Coli)
EUR 1120

Recombinant Echovirus 30 Genome polyprotein

MBS1479634-05mgEColi 0.5mg(E-Coli)
EUR 1225

Recombinant Echovirus 9 Genome polyprotein

MBS1461867-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Echovirus 9 Genome polyprotein

MBS1461867-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Echovirus 9 Genome polyprotein

MBS1461867-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Echovirus 9 Genome polyprotein

MBS1461867-01mgEColi 0.1mg(E-Coli)
EUR 1030

Recombinant Echovirus 9 Genome polyprotein

MBS1461867-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Echovirus 6 Genome polyprotein

MBS1393297-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Echovirus 6 Genome polyprotein

MBS1393297-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Echovirus 6 Genome polyprotein

MBS1393297-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Echovirus 6 Genome polyprotein

MBS1393297-01mgEColi 0.1mg(E-Coli)
EUR 1030

Recombinant Echovirus 6 Genome polyprotein

MBS1393297-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Echovirus 9 Genome polyprotein

MBS1369865-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1205

Recombinant Echovirus 9 Genome polyprotein

MBS1369865-002mgEColi 0.02mg(E-Coli)
EUR 860

Recombinant Echovirus 9 Genome polyprotein

MBS1369865-002mgYeast 0.02mg(Yeast)
EUR 995

Recombinant Echovirus 9 Genome polyprotein

MBS1369865-01mgEColi 0.1mg(E-Coli)
EUR 1030

Recombinant Echovirus 9 Genome polyprotein

MBS1369865-01mgYeast 0.1mg(Yeast)
EUR 1135

Recombinant Human rhinovirus A serotype 89 Genome polyprotein

MBS9422687-002mg 0.02mg
EUR 320

Recombinant Human rhinovirus A serotype 89 Genome polyprotein

MBS9422687-01mg 0.1mg
EUR 540

Recombinant Human rhinovirus A serotype 89 Genome polyprotein

MBS9422687-05mg 0.5mg
EUR 1360

Recombinant Human rhinovirus A serotype 89 Genome polyprotein

MBS9422687-5x05mg 5x0.5mg
EUR 5965

Recombinant CSFV Genome polyprotein protein, N-His Tag

MBS156846-005mg 0.05mg
EUR 345

Recombinant CSFV Genome polyprotein protein, N-His Tag

MBS156846-01mg 0.1mg
EUR 450

Recombinant CSFV Genome polyprotein protein, N-His Tag

MBS156846-5x01mg 5x0.1mg
EUR 1710

Recombinant Echo 9 virus Genome polyprotein

MBS1066973-005mgBaculovirus 0.05mg(Baculovirus)
EUR 880

Recombinant Echo 9 virus Genome polyprotein

MBS1066973-005mgEColi 0.05mg(E-Coli)
EUR 500

Most reports of this process of evaluating the relationship of lifetime exposure to ancestors with DNA methylation changes or small RNA expression in germ cells, as well as the relationship between the experience of ancestors and inheritance phenotype in offspring, down to the great-grandchildren in some cases. Collectively, these studies provide evidence that the phenotype can be inherited in the DNA-independent manner; the extent to which this process contributes to the development of the disease, as well as cellular and molecular regulation of this process, remain largely undefined.

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