The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review

The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review

Background: The vulnerability to a severe viral infection reported to be associated with genetic variants in immune response genes using case reports and studies GWAS. SARS-CoV-2 is a viral disease that appears that caused millions of COVID 19 cases worldwide. Approximately 15% of severe cases and some of them are accompanied by an immune system that is not regulated and the cytokine storm. There is increasing evidence that severe manifestations COVID-19 may be associated with human genetic variants in genes associated with immune deficiency and or inflammasome activation (cytokine storm).
Objective: Identification of candidate genes that may be helpful in explaining the severe COVID-19 and provide insight to understand COVID-19 is severe.

Methods: In this article, we systematically genes associated with susceptibility virus reported in human genetic studies (GWAS case reports) to understand the role of the host virus interactions and to provide insight into the pathogenesis of severe COVID 19th.

Results: We found 40 genes associated with susceptibility virus and 21 of them were related to SARS-CoV-severe and 19 severe COVID. Some of those genes involved in TLR pathways, other people in line C-lectins, and others associated with inflammasome activation (cytokine storm).

Conclusion: This compilation is a list of candidate genes that may be helpful in explaining the proper COVID-19 gene panel and included in the meta-analysis for different variants in genetic studies of a number of severe COVID 19th. In addition, we provide several hypotheses for the 19th COVID severe and possible therapeutic targets.

 The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review
The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review

Evidence for non-genetic inheritance of germline human phenotype and disease

It is becoming increasingly clear that certain inherited across generations phenotype independent of the information contained in the DNA sequence, by factors in the germ cells remain largely uncharacterized. As evidence for the inheritance of non-germline genetic phenotype and disease continues to evolve in a model organism, there are fewer reports of this phenomenon in humans, because of various complications in evaluating the legacy of this mechanism in humans. This review summarizes evidence-based legacy non-germline genetic in humans, as well as significant challenges and important warnings that should be considered when evaluating this process in the human population.

Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug

QP7370-ec-200ug 200ug
EUR 634

Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug

QP7370-ec-500ug 500ug
EUR 1060

Recombinant Human Genome polyprotein, His-SUMO, E.coli-50ug

QP7370-ec-50ug 50ug
EUR 263

Recombinant Hepatitis C Virus polyprotein, His, E.coli-10ug

QP8939-ec-10ug 10ug
EUR 326

Recombinant E.coli ssbF Protein, His-SUMO, E.coli-10ug

QP7083-10ug 10ug
EUR 355

Recombinant Human d2hgdh, His-SUMO, E.coli-10ug

QP7919-ec-10ug 10ug
EUR 200

Recombinant Human L2HGDH, His-SUMO, E.coli-10ug

QP8068-ec-10ug 10ug
EUR 200

Recombinant Human POLG2, His-SUMO, E.coli-10ug

QP8185-ec-10ug 10ug
EUR 200

Recombinant Human ALDH5A1, His-SUMO, E.coli-10ug

QP5645-ec-10ug 10ug
EUR 200

Recombinant Human COX4I1, His-SUMO, E.coli-10ug

QP5854-ec-10ug 10ug
EUR 200

Recombinant Human FDXR, His-SUMO, E.coli-10ug

QP6033-ec-10ug 10ug
EUR 200

Recombinant Human IDH3G, His-SUMO, E.coli-10ug

QP6194-ec-10ug 10ug
EUR 200

Recombinant Human ACPP Protein, His, E.coli-10ug

QP10946-HIS-10ug 10ug
EUR 201

Recombinant Human ADAM10 Protein, His, E.coli-10ug

QP10961-HIS-10ug 10ug
EUR 201

Recombinant Human ADH1A Protein, His, E.coli-10ug

QP10966-HIS-10ug 10ug
EUR 201

Recombinant Human Adipsin Protein, His, E.coli-10ug

QP10969-HIS-10ug 10ug
EUR 201

Recombinant Human AMBP Protein, His, E.coli-10ug

QP11009-HIS-10ug 10ug
EUR 201

Recombinant Human ATP1B1 Protein, His, E.coli-10ug

QP11104-HIS-10ug 10ug
EUR 201

Recombinant Human ATP1B2 Protein, His, E.coli-10ug

QP11105-HIS-10ug 10ug
EUR 201

Recombinant Human CD200 Protein, His, E.coli-10ug

QP11312-HIS-10ug 10ug
EUR 201

Recombinant Human CD207 Protein, His, E.coli-10ug

QP11314-HIS-10ug 10ug
EUR 201

Recombinant Human CD226 Protein, His, E.coli-10ug

QP11315-HIS-10ug 10ug
EUR 201

Recombinant Human CD34 Protein, His, E.coli-10ug

QP11328-HIS-10ug 10ug
EUR 201

Recombinant Human CD46 Protein, His, E.coli-10ug

QP11335-HIS-10ug 10ug
EUR 201

Recombinant Human CD5 Protein, His, E.coli-10ug

QP11338-HIS-10ug 10ug
EUR 201

Recombinant Human CD58 Protein, His, E.coli-10ug

QP11340-HIS-10ug 10ug
EUR 201

Recombinant Human CD74 Protein, His, E.coli-10ug

QP11346-HIS-10ug 10ug
EUR 201

Recombinant Human CD79B Protein, His, E.coli-10ug

QP11348-HIS-10ug 10ug
EUR 201

Recombinant Human CD84 Protein, His, E.coli-10ug

QP11352-HIS-10ug 10ug
EUR 201

Recombinant Human CD99 Protein, His, E.coli-10ug

QP11359-HIS-10ug 10ug
EUR 201

Recombinant Human CDC37 Protein, His, E.coli-10ug

QP11364-HIS-10ug 10ug
EUR 201

Recombinant Human CDK1 Protein, His, E.coli-10ug

QP11372-HIS-10ug 10ug
EUR 201

Recombinant Human CST4 Protein, His, E.coli-10ug

QP11544-HIS-10ug 10ug
EUR 201

Recombinant Human CSTF1 Protein, His, E.coli-10ug

QP11548-HIS-10ug 10ug
EUR 201

Recombinant Human CTHRC1 Protein, His, E.coli-10ug

QP11554-HIS-10ug 10ug
EUR 201

Recombinant Human EDA2R Protein, His, E.coli-10ug

QP11743-HIS-10ug 10ug
EUR 201

Recombinant Human EDAR Protein, His, E.coli-10ug

QP11744-HIS-10ug 10ug
EUR 201

Recombinant Human EFNB3 Protein, His, E.coli-10ug

QP11756-HIS-10ug 10ug
EUR 201

Recombinant Human ESM1 Protein, His, E.coli-10ug

QP11810-HIS-10ug 10ug
EUR 201

Recombinant Human FCGR3A Protein, His, E.coli-10ug

QP11860-HIS-10ug 10ug
EUR 201

Recombinant Human PSG1 Protein, His, E.coli-10ug

QP13179-HIS-10ug 10ug
EUR 201

Recombinant Human PTX3 Protein, His, E.coli-10ug

QP13217-HIS-10ug 10ug
EUR 201

Recombinant Human RBP4 Protein, His, E.coli-10ug

QP13283-HIS-10ug 10ug
EUR 201

Recombinant Human REN Protein, His, E.coli-10ug

QP13296-HIS-10ug 10ug
EUR 201

Recombinant Human RLBP1 Protein, His, E.coli-10ug

QP13321-HIS-10ug 10ug
EUR 201

Recombinant Human RNASE3 Protein, His, E.coli-10ug

QP13323-HIS-10ug 10ug
EUR 201

Recombinant Human S100A8 Protein, His, E.coli-10ug

QP13399-HIS-10ug 10ug
EUR 201

Recombinant Human SLAMF6 Protein, His, E.coli-10ug

QP13519-HIS-10ug 10ug
EUR 201

Recombinant Human STYX Protein, His, E.coli-10ug

QP13638-HIS-10ug 10ug
EUR 201

Recombinant Human TACSTD2 Protein, His, E.coli-10ug

QP13683-HIS-10ug 10ug
EUR 201

Recombinant Human TINAGL1 Protein, His, E.coli-10ug

QP13754-HIS-10ug 10ug
EUR 201

Recombinant Human TNNI2 Protein, His, E.coli-10ug

QP13776-HIS-10ug 10ug
EUR 201

Recombinant Human TSLPR Protein, His, E.coli-10ug

QP13827-HIS-10ug 10ug
EUR 201

Recombinant Human ULBP1 Protein, His, E.coli-10ug

QP13885-HIS-10ug 10ug
EUR 201

Recombinant Human ULBP2 Protein, His, E.coli-10ug

QP13886-HIS-10ug 10ug
EUR 201

Recombinant Human UMPS Protein, His, E.coli-10ug

QP13893-HIS-10ug 10ug
EUR 201

Recombinant Human YWHAE Protein, His, E.coli-10ug

QP13985-HIS-10ug 10ug
EUR 201

Recombinant Human YWHAG Protein, His, E.coli-10ug

QP13986-HIS-10ug 10ug
EUR 201

Recombinant Human GZMK Protein, His, E.coli-10ug

QP12073-HIS-10ug 10ug
EUR 201

Recombinant Human HAVCR1 Protein, His, E.coli-10ug

QP12115-HIS-10ug 10ug
EUR 201

Recombinant Human HEXA Protein, His, E.coli-10ug

QP12224-HIS-10ug 10ug
EUR 201

Recombinant Human IGFBP7 Protein, His, E.coli-10ug

QP12384-HIS-10ug 10ug
EUR 201

Recombinant Human IL13RA2 Protein, His, E.coli-10ug

QP12406-HIS-10ug 10ug
EUR 201

Recombinant Human ITGB1 Protein, His, E.coli-10ug

QP12462-HIS-10ug 10ug
EUR 201

Recombinant Human LIN28 Protein, His, E.coli-10ug

QP12571-HIS-10ug 10ug
EUR 201

Recombinant Human LIPG Protein, His, E.coli-10ug

QP12577-HIS-10ug 10ug
EUR 201

Recombinant Human LPL Protein, His, E.coli-10ug

QP12581-HIS-10ug 10ug
EUR 201

Recombinant Human LUM Protein, His, E.coli-10ug

QP12598-HIS-10ug 10ug
EUR 201

Recombinant Human MFAP4 Protein, His, E.coli-10ug

QP12691-HIS-10ug 10ug
EUR 201

Recombinant Human NXPH1 Protein, His, E.coli-10ug

QP12912-HIS-10ug 10ug
EUR 201

Recombinant Human PDCD1LG2 Protein, His, E.coli-10ug

QP12985-HIS-10ug 10ug
EUR 201

Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-10ug

QP7125-10ug 10ug
EUR 355

Recombinant E.coli nrdB Protein, His-SUMO, E.coli-10ug

QP6953-ec-10ug 10ug
EUR 326

Recombinant E.coli plsC Protein, His-SUMO, E.coli-10ug

QP7206-ec-10ug 10ug
EUR 326

Recombinant E.coli fkpA Protein, His-SUMO, E.coli-10ug

QP7261-ec-10ug 10ug
EUR 326

Recombinant E.coli nrdA Protein, His-SUMO, E.coli-10ug

QP7262-ec-10ug 10ug
EUR 326

Recombinant E.coli ruvA Protein, His-SUMO, E.coli-10ug

QP7321-ec-10ug 10ug
EUR 326

Recombinant E.coli fabF Protein, His-SUMO, E.coli-10ug

QP7326-ec-10ug 10ug
EUR 326

Recombinant E.coli LptA Protein, His-SUMO, E.coli-10ug

QP7331-ec-10ug 10ug
EUR 326

Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-10ug

QP7336-ec-10ug 10ug
EUR 326

Recombinant E.coli ruvB Protein, His-SUMO, E.coli-10ug

QP7392-ec-10ug 10ug
EUR 326

Recombinant E.coli ruvC Protein, His-SUMO, E.coli-10ug

QP7393-ec-10ug 10ug
EUR 326

Recombinant E.coli tetR Protein, His-SUMO, E.coli-10ug

QP7416-ec-10ug 10ug
EUR 326

Recombinant E.coli Agmatinase Protein, His-SUMO, E.coli-10ug

QP5622-ec-10ug 10ug
EUR 326

Recombinant Human IL 28A Protein, His, E.coli-10ug

QP12397-HIS-10ug 10ug
EUR 201

Recombinant Human Genome polyprotein, His, Yeast-100ug

QP7370-ye-100ug 100ug
EUR 480

Recombinant Human Genome polyprotein, His, Yeast-1mg

QP7370-ye-1mg 1mg
EUR 1885

Recombinant Human Genome polyprotein, His, Yeast-200ug

QP7370-ye-200ug 200ug
EUR 744

Recombinant Human Genome polyprotein, His, Yeast-500ug

QP7370-ye-500ug 500ug
EUR 1206

Recombinant Human Genome polyprotein, His, Yeast-50ug

QP7370-ye-50ug 50ug
EUR 299

Recombinant Bovine Nucleoprotein, His-SUMO, E.coli-10ug

QP7198-ec-10ug 10ug
EUR 326

Recombinant Zebrafish d2hgdh, His-SUMO, E.coli-10ug

QP7418-ec-10ug 10ug
EUR 326

Recombinant Mouse Hadh, His-SUMO, E.coli-10ug

QP7685-ec-10ug 10ug
EUR 272

Recombinant Mouse Agxt, His-SUMO, E.coli-10ug

QP5628-ec-10ug 10ug
EUR 272

Recombinant Mouse Frataxin, His-SUMO, E.coli-10ug

QP6059-ec-10ug 10ug
EUR 272

Recombinant Bovine L2HGDH, His-SUMO, E.coli-10ug

QP6285-ec-10ug 10ug
EUR 326

Most reports of this process of evaluating the relationship of lifetime exposure to ancestors with DNA methylation changes or small RNA expression in germ cells, as well as the relationship between the experience of ancestors and inheritance phenotype in offspring, down to the great-grandchildren in some cases. Collectively, these studies provide evidence that the phenotype can be inherited in the DNA-independent manner; the extent to which this process contributes to the development of the disease, as well as cellular and molecular regulation of this process, remain largely undefined.

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