The role of Host Genetics in susceptibility to severe viral infections in humans and INSIGHTS into host genetics of severe COVID-19: A systematic review
Background: The vulnerability to a severe viral infection reported to be associated with genetic variants in immune response genes using case reports and studies GWAS. SARS-CoV-2 is a viral disease that appears that caused millions of COVID 19 cases worldwide. Approximately 15% of severe cases and some of them are accompanied by an immune system that is not regulated and the cytokine storm. There is increasing evidence that severe manifestations COVID-19 may be associated with human genetic variants in genes associated with immune deficiency and or inflammasome activation (cytokine storm).
Objective: Identification of candidate genes that may be helpful in explaining the severe COVID-19 and provide insight to understand COVID-19 is severe.
Methods: In this article, we systematically genes associated with susceptibility virus reported in human genetic studies (GWAS case reports) to understand the role of the host virus interactions and to provide insight into the pathogenesis of severe COVID 19th.
Results: We found 40 genes associated with susceptibility virus and 21 of them were related to SARS-CoV-severe and 19 severe COVID. Some of those genes involved in TLR pathways, other people in line C-lectins, and others associated with inflammasome activation (cytokine storm).
Conclusion: This compilation is a list of candidate genes that may be helpful in explaining the proper COVID-19 gene panel and included in the meta-analysis for different variants in genetic studies of a number of severe COVID 19th. In addition, we provide several hypotheses for the 19th COVID severe and possible therapeutic targets.
Evidence for non-genetic inheritance of germline human phenotype and disease
It is becoming increasingly clear that certain inherited across generations phenotype independent of the information contained in the DNA sequence, by factors in the germ cells remain largely uncharacterized. As evidence for the inheritance of non-germline genetic phenotype and disease continues to evolve in a model organism, there are fewer reports of this phenomenon in humans, because of various complications in evaluating the legacy of this mechanism in humans. This review summarizes evidence-based legacy non-germline genetic in humans, as well as significant challenges and important warnings that should be considered when evaluating this process in the human population.
 Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug |
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| QP7370-ec-200ug | EnQuireBio | 200ug | EUR 634 |
 Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug |
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| QP7370-ec-500ug | EnQuireBio | 500ug | EUR 1060 |
 Recombinant Human Genome polyprotein, His-SUMO, E.coli-50ug |
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| QP7370-ec-50ug | EnQuireBio | 50ug | EUR 263 |
 Recombinant Hepatitis C Virus polyprotein, His, E.coli-10ug |
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| QP8939-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli ssbF Protein, His-SUMO, E.coli-10ug |
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| QP7083-10ug | EnQuireBio | 10ug | EUR 355 |
 Recombinant Human d2hgdh, His-SUMO, E.coli-10ug |
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| QP7919-ec-10ug | EnQuireBio | 10ug | EUR 200 |
 Recombinant Human L2HGDH, His-SUMO, E.coli-10ug |
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| QP8068-ec-10ug | EnQuireBio | 10ug | EUR 200 |
 Recombinant Human POLG2, His-SUMO, E.coli-10ug |
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| QP8185-ec-10ug | EnQuireBio | 10ug | EUR 200 |
 Recombinant Human ALDH5A1, His-SUMO, E.coli-10ug |
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| QP5645-ec-10ug | EnQuireBio | 10ug | EUR 200 |
 Recombinant Human COX4I1, His-SUMO, E.coli-10ug |
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| QP5854-ec-10ug | EnQuireBio | 10ug | EUR 200 |
 Recombinant Human FDXR, His-SUMO, E.coli-10ug |
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| QP6033-ec-10ug | EnQuireBio | 10ug | EUR 200 |
 Recombinant Human IDH3G, His-SUMO, E.coli-10ug |
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| QP6194-ec-10ug | EnQuireBio | 10ug | EUR 200 |
 Recombinant Human ACPP Protein, His, E.coli-10ug |
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| QP10946-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human ADAM10 Protein, His, E.coli-10ug |
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| QP10961-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human ADH1A Protein, His, E.coli-10ug |
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| QP10966-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human Adipsin Protein, His, E.coli-10ug |
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| QP10969-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human AMBP Protein, His, E.coli-10ug |
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| QP11009-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human ATP1B1 Protein, His, E.coli-10ug |
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| QP11104-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human ATP1B2 Protein, His, E.coli-10ug |
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| QP11105-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD200 Protein, His, E.coli-10ug |
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| QP11312-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD207 Protein, His, E.coli-10ug |
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| QP11314-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD226 Protein, His, E.coli-10ug |
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| QP11315-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD34 Protein, His, E.coli-10ug |
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| QP11328-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD46 Protein, His, E.coli-10ug |
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| QP11335-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD5 Protein, His, E.coli-10ug |
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| QP11338-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD58 Protein, His, E.coli-10ug |
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| QP11340-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD74 Protein, His, E.coli-10ug |
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| QP11346-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD79B Protein, His, E.coli-10ug |
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| QP11348-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD84 Protein, His, E.coli-10ug |
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| QP11352-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CD99 Protein, His, E.coli-10ug |
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| QP11359-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CDC37 Protein, His, E.coli-10ug |
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| QP11364-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CDK1 Protein, His, E.coli-10ug |
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| QP11372-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CST4 Protein, His, E.coli-10ug |
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| QP11544-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CSTF1 Protein, His, E.coli-10ug |
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| QP11548-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human CTHRC1 Protein, His, E.coli-10ug |
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| QP11554-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human EDA2R Protein, His, E.coli-10ug |
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| QP11743-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human EDAR Protein, His, E.coli-10ug |
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| QP11744-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human EFNB3 Protein, His, E.coli-10ug |
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| QP11756-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human ESM1 Protein, His, E.coli-10ug |
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| QP11810-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human FCGR3A Protein, His, E.coli-10ug |
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| QP11860-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human PSG1 Protein, His, E.coli-10ug |
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| QP13179-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human PTX3 Protein, His, E.coli-10ug |
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| QP13217-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human RBP4 Protein, His, E.coli-10ug |
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| QP13283-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human REN Protein, His, E.coli-10ug |
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| QP13296-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human RLBP1 Protein, His, E.coli-10ug |
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| QP13321-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human RNASE3 Protein, His, E.coli-10ug |
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| QP13323-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human S100A8 Protein, His, E.coli-10ug |
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| QP13399-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human SLAMF6 Protein, His, E.coli-10ug |
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| QP13519-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human STYX Protein, His, E.coli-10ug |
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| QP13638-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human TACSTD2 Protein, His, E.coli-10ug |
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| QP13683-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human TINAGL1 Protein, His, E.coli-10ug |
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| QP13754-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human TNNI2 Protein, His, E.coli-10ug |
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| QP13776-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human TSLPR Protein, His, E.coli-10ug |
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| QP13827-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human ULBP1 Protein, His, E.coli-10ug |
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| QP13885-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human ULBP2 Protein, His, E.coli-10ug |
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| QP13886-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human UMPS Protein, His, E.coli-10ug |
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| QP13893-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human YWHAE Protein, His, E.coli-10ug |
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| QP13985-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human YWHAG Protein, His, E.coli-10ug |
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| QP13986-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human GZMK Protein, His, E.coli-10ug |
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| QP12073-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human HAVCR1 Protein, His, E.coli-10ug |
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| QP12115-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human HEXA Protein, His, E.coli-10ug |
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| QP12224-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human IGFBP7 Protein, His, E.coli-10ug |
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| QP12384-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human IL13RA2 Protein, His, E.coli-10ug |
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| QP12406-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human ITGB1 Protein, His, E.coli-10ug |
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| QP12462-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human LIN28 Protein, His, E.coli-10ug |
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| QP12571-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human LIPG Protein, His, E.coli-10ug |
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| QP12577-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human LPL Protein, His, E.coli-10ug |
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| QP12581-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human LUM Protein, His, E.coli-10ug |
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| QP12598-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human MFAP4 Protein, His, E.coli-10ug |
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| QP12691-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human NXPH1 Protein, His, E.coli-10ug |
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| QP12912-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human PDCD1LG2 Protein, His, E.coli-10ug |
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| QP12985-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant hepatitis Non-structural polyprotein pORF1 Protein, His, E.coli-10ug |
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| QP7125-10ug | EnQuireBio | 10ug | EUR 355 |
 Recombinant E.coli nrdB Protein, His-SUMO, E.coli-10ug |
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| QP6953-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli plsC Protein, His-SUMO, E.coli-10ug |
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| QP7206-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli fkpA Protein, His-SUMO, E.coli-10ug |
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| QP7261-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli nrdA Protein, His-SUMO, E.coli-10ug |
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| QP7262-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli ruvA Protein, His-SUMO, E.coli-10ug |
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| QP7321-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli fabF Protein, His-SUMO, E.coli-10ug |
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| QP7326-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli LptA Protein, His-SUMO, E.coli-10ug |
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| QP7331-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli Exopolyphosphatase Protein, His-SUMO, E.coli-10ug |
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| QP7336-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli ruvB Protein, His-SUMO, E.coli-10ug |
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| QP7392-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli ruvC Protein, His-SUMO, E.coli-10ug |
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| QP7393-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli tetR Protein, His-SUMO, E.coli-10ug |
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| QP7416-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant E.coli Agmatinase Protein, His-SUMO, E.coli-10ug |
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| QP5622-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant Human IL 28A Protein, His, E.coli-10ug |
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| QP12397-HIS-10ug | EnQuireBio | 10ug | EUR 201 |
 Recombinant Human Genome polyprotein, His, Yeast-100ug |
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| QP7370-ye-100ug | EnQuireBio | 100ug | EUR 480 |
 Recombinant Human Genome polyprotein, His, Yeast-1mg |
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| QP7370-ye-1mg | EnQuireBio | 1mg | EUR 1885 |
 Recombinant Human Genome polyprotein, His, Yeast-200ug |
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| QP7370-ye-200ug | EnQuireBio | 200ug | EUR 744 |
 Recombinant Human Genome polyprotein, His, Yeast-500ug |
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| QP7370-ye-500ug | EnQuireBio | 500ug | EUR 1206 |
 Recombinant Human Genome polyprotein, His, Yeast-50ug |
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| QP7370-ye-50ug | EnQuireBio | 50ug | EUR 299 |
 Recombinant Bovine Nucleoprotein, His-SUMO, E.coli-10ug |
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| QP7198-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant Zebrafish d2hgdh, His-SUMO, E.coli-10ug |
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| QP7418-ec-10ug | EnQuireBio | 10ug | EUR 326 |
 Recombinant Mouse Hadh, His-SUMO, E.coli-10ug |
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| QP7685-ec-10ug | EnQuireBio | 10ug | EUR 272 |
 Recombinant Mouse Agxt, His-SUMO, E.coli-10ug |
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| QP5628-ec-10ug | EnQuireBio | 10ug | EUR 272 |
 Recombinant Mouse Frataxin, His-SUMO, E.coli-10ug |
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| QP6059-ec-10ug | EnQuireBio | 10ug | EUR 272 |
 Recombinant Bovine L2HGDH, His-SUMO, E.coli-10ug |
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| QP6285-ec-10ug | EnQuireBio | 10ug | EUR 326 |
Most reports of this process of evaluating the relationship of lifetime exposure to ancestors with DNA methylation changes or small RNA expression in germ cells, as well as the relationship between the experience of ancestors and inheritance phenotype in offspring, down to the great-grandchildren in some cases. Collectively, these studies provide evidence that the phenotype can be inherited in the DNA-independent manner; the extent to which this process contributes to the development of the disease, as well as cellular and molecular regulation of this process, remain largely undefined.
