MicroRNAs in Genetic Etiology of Human Diseases

MicroRNAs in Genetic Etiology of Human Diseases

Since their first discovery greater than 20 years in the past, miRNAs have been topic to deliberate analysis and evaluation for revealing their physiological or pathological involvement. Regulatory roles of miRNAs in sign transduction, gene expression, and mobile processes in improvement, differentiation, proliferation, apoptosis, and homeostasis additionally suggest their vital function in illness pathogenesis.
Their roles in most cancers, neurodegenerative ailments, and different systemic ailments have been studied broadly. In these regulatory pathways, their mutations and goal sequence variations play vital roles to find out their purposeful repertoire. On this chapter, we summarize research that investigated the function of mutations, polymorphisms, and different variations of miRNAs in respect to pathological processes.

INFIMA leverages multi-omics mannequin organism information to establish effector genes of human GWAS variants

Genome-wide affiliation research reveal many non-coding variants related to advanced traits. Nonetheless, mannequin organism research largely stay as an untapped useful resource for unveiling the effector genes of non-coding variants.
We develop INFIMA, Integrative Wonderful-Mapping, to pinpoint causal SNPs for range outbred (DO) mice eQTL by integrating founder mice multi-omics information together with ATAC-seq, RNA-seq, footprinting, and in silico mutation evaluation.
We show INFIMA’s superior efficiency in comparison with alternate options with human and mouse chromatin conformation seize datasets. We apply INFIMA to establish novel effector genes for GWAS variants related to diabetes.

Discrete genetic loci in human intestine Bacteroides thetaiotaomicron confer pectin metabolism

Though the polysaccharide utilization loci (PULs) activated by pectin have been outlined, because of the advanced of side-chain construction, the degradative mechanisms nonetheless stay imprecise. Thus, we hypothesize that there might produce other particular PULs to focus on pectin. Right here, we characterize loci-encoded proteins expressed by Bacteroides thetaiotaomicron (BT) which might be concerned within the pectin capturing, importation, de-branching and degradation into monosaccharides.
Completely, 4 PULs comprise ten enzymes and 4 glycan binding proteins which together with a novel floor enzyme and a floor glycan binding protein are recognized. Notably, PUL2 and PUL3 haven’t been reported to this point.
Additional, we present that the degradation merchandise assist the expansion of different Bacteroides spp. and probiotics. As well as, genes concerned on this course of are conservative in different Bacteroides spp. Our outcomes additional spotlight the contribution of Bacteroides spp. to metabolism the pectic community.

Transcriptomic evaluation of human brains with Alzheimer’s illness reveals the altered expression of synaptic genes linked to cognitive deficits

Alzheimer’s illness is a progressive neurodegenerative dysfunction related to reminiscence loss and impaired govt operate. The molecular underpinnings inflicting cognitive deficits in Alzheimer’s illness are loosely understood. Right here, we carried out cross-study large-scale transcriptomic analyses of postmortem prefrontal cortex derived from Alzheimer’s illness sufferers to disclose the function of aberrant gene expression on this illness.
We recognized that probably the most outstanding modifications in prefrontal cortex of Alzheimer’s illness people was the downregulation of genes in excitatory and inhibitory neurons which might be related to synaptic features, significantly the SNARE-binding advanced, which is important for vesicle docking and neurotransmitter launch.
Evaluating genomic information of Alzheimer’s illness with proteomic information of cognitive trajectory, we discovered that most of the misplaced synaptic genes in Alzheimer’s illness encode hub proteins whose elevated abundance is required for cognitive stability. This examine has revealed potential molecular targets for therapeutic intervention of cognitive decline related to Alzheimer’s illness.
MicroRNAs in Genetic Etiology of Human Diseases

Uncommon Genetic Issues: Novel Therapy Methods and Insights Into Human Biology

The final decade has seen a dramatic enhance in progressive concepts for the therapy of genetic problems for which no healing therapies exist. Gene and protein substitute therapies stand out as novel approaches to deal with a choose group of those ailments, equivalent to sure tissue fragility problems.
Additional, the arrival of stem cell approaches, equivalent to induced pluripotent stem cells (iPSC) know-how, has led to the event of latest strategies of making substitute tissues for regenerative medication. This coincided with the invention of genome modifying strategies, which permit for the correction of disease-causing mutations.
The end result of those discoveries means that new and progressive therapies for monogenetic problems affecting single organs or tissues are on the horizon. Challenges stay, nevertheless, particularly with ailments that concurrently have an effect on a number of tissues and organs throughout improvement. Examples of this group of ailments embrace ectodermal dysplasias, genetic problems affecting the event of tissues and organs such because the pores and skin, cornea, and epithelial appendages.
Gene or protein substitute methods are unlikely to achieve success in addressing the multiorgan phenotype of those ailments. As an alternative, we imagine {that a} simpler method might be to concentrate on correcting phenotypes in essentially the most severely affected tissues. This might embrace the technology of substitute tissues or the identification of pharmaceutical compounds that right illness pathways in particular tissues.

Meta-Evaluation-Assisted Detection of Gravity-Delicate Genes in Human Vascular Endothelial Cells

Gravity impacts the operate and upkeep of organs, equivalent to bones, muscular tissues, and the guts. A number of research have used DNA microarrays to establish genes with altered expressions in response to gravity. Nonetheless, it’s technically difficult to mix the outcomes from varied microarray datasets due to their totally different information constructions.
We hypothesized that it’s attainable to establish frequent modifications in gene expression from the DNA microarray datasets obtained underneath varied situations and strategies. On this examine, we grouped homologous genes to carry out a meta-analysis of a number of vascular endothelial cell and skeletal muscle datasets. In response to the t-distributed stochastic neighbor embedding (t-SNE) evaluation, the modifications within the gene expression sample in vascular endothelial cells fashioned particular clusters.
We additionally recognized candidate genes in endothelial cells that responded to gravity. Additional, we uncovered human umbilical vein endothelial cells (HUVEC) to simulated microgravity (SMG) utilizing a clinostat and measured the expression ranges of the candidate genes.

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

AP71163 1mg
EUR 1978

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

AP72984 each Ask for price

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

AP77542 1mg
EUR 1978

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial

CSB-EP362073HQD 3389 mg Ask for price

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial

CSB-EP362073HQDb0 3390 mg Ask for price

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

RPC22779-100ug 100ug
EUR 460.9

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

RPC22779-1mg 1mg
EUR 2237.8

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial

RPC22779-20ug 20ug
EUR 258.7

Recombinant Human rhinovirus A serotype 89 Genome polyprotein, partial, Biotinylated

CSB-EP362073HQD-B 7058 mg Ask for price

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial,Biotinylated

RPC27677-100ug 100ug
EUR 614.3

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial,Biotinylated

RPC27677-1mg 1mg
EUR 2373.6

Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial,Biotinylated

RPC27677-20ug 20ug
EUR 468

Human rhinovirus A serotype 89 Genome polyprotein

1-CSB-YP362073HQD
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  • 100ug
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  • 1MG
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in Yeast

Human rhinovirus A serotype 89 Genome polyprotein

1-CSB-EP362073HQD
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli

Human rhinovirus A serotype 89 Genome polyprotein

1-CSB-EP362073HQDb0
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Description: Recombinant Human rhinovirus A serotype 89 Genome polyprotein,partial expressed in E.coli

Rhinovirus A serotype 89 Genome polyprotein Antibody

20-abx109372
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  • 100 ug
  • 1 mg
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  • 20 ug
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Rhinovirus A serotype 89 Genome polyprotein Antibody

abx109372-100l 100 µl
EUR 162.5

Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP)

20-abx108723
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Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP)

abx108723-100g 100 µg
EUR 362.5

Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP)

abx108723-20g 20 µg
EUR 162.5

Rhinovirus A serotype 89 Genome polyprotein Antibody (HRP)

abx108723-50g 50 µg
EUR 250

Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC)

20-abx107303
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Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC)

abx107303-100g 100 µg
EUR 362.5

Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC)

abx107303-20g 20 µg
EUR 162.5

Rhinovirus A serotype 89 Genome polyprotein Antibody (FITC)

abx107303-50g 50 µg
EUR 250

Recombinant Human parechovirus 1 Genome polyprotein

CSB-YP734409HCAV 9748 mg Ask for price

Recombinant Human Genome polyprotein, His, Yeast-1mg

QP7370-ye-1mg 1mg
EUR 2262

Recombinant Human Genome polyprotein, His, Yeast-10ug

QP7370-ye-10ug 10ug
EUR 283.2

Recombinant Human Genome polyprotein, His, Yeast-50ug

QP7370-ye-50ug 50ug
EUR 358.8

Recombinant Human Genome polyprotein, His, Yeast-100ug

QP7370-ye-100ug 100ug
EUR 576

Recombinant Human Genome polyprotein, His, Yeast-200ug

QP7370-ye-200ug 200ug
EUR 892.8

Recombinant Human Genome polyprotein, His, Yeast-500ug

QP7370-ye-500ug 500ug
EUR 1447.2

Recombinant Hepatitis C Genome polyprotein

CSB-RP184674Ba 5430 mg Ask for price

Recombinant Hepatitis C Genome polyprotein

RPC24458-100ug 100ug
EUR 721.6

Recombinant Hepatitis C Genome polyprotein

RPC24458-20ug 20ug
EUR 448.1

Recombinant Human parechovirus 2 Genome polyprotein, partial

CSB-EP529147HXJ 9583 mg Ask for price

Recombinant Human parechovirus 1 Genome polyprotein, partial

CSB-EP734409HCAV 9651 mg Ask for price

Recombinant Human Genome polyprotein, His-SUMO, E.coli-1mg

QP7370-ec-1mg 1mg
EUR 1958.4

Recombinant Human Genome polyprotein, His-SUMO, E.coli-10ug

QP7370-ec-10ug 10ug
EUR 240

Recombinant Human Genome polyprotein, His-SUMO, E.coli-50ug

QP7370-ec-50ug 50ug
EUR 315.6

Recombinant Human Genome polyprotein, His-SUMO, E.coli-100ug

QP7370-ec-100ug 100ug
EUR 489.6

Recombinant Human Genome polyprotein, His-SUMO, E.coli-200ug

QP7370-ec-200ug 200ug
EUR 760.8

Recombinant Human Genome polyprotein, His-SUMO, E.coli-500ug

QP7370-ec-500ug 500ug
EUR 1272

Recombinant JEV Genome polyprotein (aa 2528-3432) Protein

VAng-Wyb3447-1mgEcoli 1 mg (E. coli)
EUR 9926.4
Description: Japanese encephalitis virus (strain Jaoars982) Genome polyprotein, recombinant protein.

Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial

CSB-EP333180HFD 3004 mg Ask for price

Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial

CSB-MP333180HFD 4998 mg Ask for price

Recombinant Zika virus Genome polyprotein, partial

CSB-EP3643GOZ3 7769 mg Ask for price

Recombinant Enterovirus A71 Genome polyprotein, partial

CSB-EP3114GLA 7385 mg Ask for price

Recombinant Enterovirus A71 Genome polyprotein, partial

CSB-EP3114GLAa2 7384 mg Ask for price

Recombinant Enterovirus A71 Genome polyprotein, partial

CSB-EP3114GLAe0 7511 mg Ask for price

Recombinant Enterovirus A71 Genome polyprotein, partial

CSB-EP3114GLAe1 7917 mg Ask for price

Recombinant Enterovirus A71 Genome polyprotein,partial

RPC28548-100ug 100ug
EUR 801.9

Recombinant Enterovirus A71 Genome polyprotein,partial

RPC28548-1mg 1mg
EUR 2885.2

Recombinant Enterovirus A71 Genome polyprotein,partial

RPC28548-20ug 20ug
EUR 448.1

Recombinant Enterovirus A71 Genome polyprotein,partial

RPC28549-100ug 100ug
EUR 801.9

Recombinant Enterovirus A71 Genome polyprotein,partial

RPC28549-1mg 1mg
EUR 2885.2

Recombinant Enterovirus A71 Genome polyprotein,partial

RPC28549-20ug 20ug
EUR 448.1

Recombinant YFV Genome polyprotein Protein (aa 286-730)

VAng-Cr6541-1mgEcoli 1 mg (E. coli)
EUR 5751.6
Description: YFV Genome polyprotein, partial, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 286-730)

VAng-Cr6541-500gEcoli 500 µg (E. coli)
EUR 3657.6
Description: YFV Genome polyprotein, partial, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 286-730)

VAng-Cr6541-50gEcoli 50 µg (E. coli)
EUR 1083.6
Description: YFV Genome polyprotein, partial, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 1-101)

VAng-Cr6542-1mgEcoli 1 mg (E. coli)
EUR 3408
Description: YFV Genome polyprotein, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 1-101)

VAng-Cr6542-500gEcoli 500 µg (E. coli)
EUR 2452.8
Description: YFV Genome polyprotein, recombinant protein.

Recombinant YFV Genome polyprotein Protein (aa 1-101)

VAng-Cr6542-50gEcoli 50 µg (E. coli)
EUR 1693.2
Description: YFV Genome polyprotein, recombinant protein.

Recombinant Coxsackievirus B3 Genome polyprotein, partial

CSB-EP361017CRM1 8884 mg Ask for price

Recombinant West Nile virus Genome polyprotein, partial

CSB-EP356974WAF2 9323 mg Ask for price

Recombinant Hepatitis C virus Genome polyprotein,partial

AP72393 each Ask for price

Recombinant Yellow fever virus Genome polyprotein,partial

AP77947 1mg
EUR 2826

Recombinant Yellow fever virus Genome polyprotein, partial

CSB-EP365905YAC1 3485 mg Ask for price

Recombinant Yellow fever virus Genome polyprotein,partial

RPC22821-100ug 100ug
EUR 721.6

Recombinant Yellow fever virus Genome polyprotein,partial

RPC22821-1mg 1mg
EUR 2884.7

Recombinant Yellow fever virus Genome polyprotein,partial

RPC22821-20ug 20ug
EUR 448.1

Recombinant Human parechovirus 2 Genome polyprotein, partial, Biotinylated

CSB-EP897051HHAL-B 10843 mg Ask for price

Recombinant Human parechovirus 1 Genome polyprotein, partial, Biotinylated

CSB-EP734409HCAV-B 10800 mg Ask for price

Recombinant YFV Genome polyprotein (NS4A) Protein (aa 1-3412)

VAng-Cr6545-inquire inquire Ask for price
Description: YFV (isolate Uganda/A7094A4/1948) Genome polyprotein (NS4A), recombinant protein.

Recombinant Dengue virus type 2 Genome polyprotein, partial

CSB-YP530838DCF 7267 mg Ask for price

Recombinant Japanese encephalitis virus Genome polyprotein, partial

CSB-EP189574Ba 2537 mg Ask for price

Recombinant Bovine viral diarrhea virus Genome polyprotein , partial

CSB-YP312464BKX1 6140 mg Ask for price

Recombinant Classical swine fever virus Genome polyprotein, partial

CSB-YP4953GLU 12085 mg Ask for price

Recombinant Bovine viral diarrhea virus Genome polyprotein, partial

CSB-BP312464BKX1 139 mg Ask for price

Recombinant Classical swine fever virus Genome polyprotein, partial

CSB-BP4334GLU 10139 mg Ask for price

Recombinant St. louis encephalitis virus Genome polyprotein, partial

CSB-EP357746SKT 9322 mg Ask for price

Recombinant Classical swine fever virus Genome polyprotein, partial

CSB-EP4953GLU 11663 mg Ask for price

Recombinant Bovine viral diarrhea virus Genome polyprotein, partial

CSB-EP312464BKX1 2704 mg Ask for price

OPCA05394-20UG - GENOME POLYPROTEIN Recombinant Protein (isolate 1)

OPCA05394-20UG 20ug
EUR 339

Recombinant Bovine viral diarrhea virus Genome polyprotein,partial

RPC28130-100ug 100ug
EUR 1544.5

Recombinant Bovine viral diarrhea virus Genome polyprotein,partial

RPC28130-20ug 20ug
EUR 580.8

Recombinant Hepatitis C virus genotype 1a (isolate 1) (HCV) Genome polyprotein(E1),partial

AP70969 1mg
EUR 2826

Recombinant Dengue virus type 2 Genome polyprotein (Q1642N), partial

CSB-EP3044GLD(M) 11736 mg Ask for price

Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial

CSB-YP530838HVQ(A3) 6465 mg Ask for price

Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial

CSB-YP530838HVQ(A4) 6466 mg Ask for price

Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial

AP73727 each Ask for price

Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial

AP73728 each Ask for price

Recombinant Human Rhinovirus 16 VP3 (a.a. 331-562) [His]

DAG-WT1151 1 mg
EUR 2000
Description: Recombinant

Recombinant Tick-borne encephalitis virus Genome polyprotein, partial

CSB-EP3056GKR 2646 mg Ask for price

Recombinant Human Rhinovirus 16 VP4 (a.a. 2-69) [His]

DAG-WT1152 1 mg
EUR 2000
Description: Recombinant

Recombinant Dengue virus 2 Genome polyprotein (T2493G,G2494S,I2762T), partial

CSB-EP2239GLD(M) 11735 mg Ask for price

Equine Rhinitis A Virus Genome Polyprotein Antibody

abx345840-100g 100 µg Ask for price

Equine Rhinitis A Virus Genome Polyprotein Antibody

abx345840-20g 20 µg
EUR 250

Equine Rhinitis A Virus Genome Polyprotein Antibody

abx345840-50g 50 µg
EUR 350

Genome Polyprotein Antibody

20-abx109417
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  • 100 ug
  • 1 mg
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Genome polyprotein Antibody

20-abx300967
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Genome polyprotein Antibody

1-CSB-PA18549A0Rb
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  • 100ug
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA333180LA01HFD
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  • 100ug
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA362073LA01HQD
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  • 100ug
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

CSB-PA4643XA11GSV 100ul / 50ul
EUR 299
Description: Genome polyprotein

Genome polyprotein Antibody

CSB-PA4644XA11GSW 100ul / 50ul
EUR 299
Description: Genome polyprotein

Genome polyprotein Antibody

1-CSB-PA714772LA01HYH
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Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Unconjugated. Tested in the following application: ELISA

Genome Polyprotein Antibody

abx109417-100l 100 µl
EUR 162.5

Genome polyprotein Antibody

abx300967-100g 100 µg
EUR 362.5

Genome polyprotein Antibody

abx300967-20g 20 µg
EUR 162.5

Genome polyprotein Antibody

abx300967-50g 50 µg
EUR 250

Recombinant Tick-borne encephalitis virus European subtype Genome polyprotein, partial

CSB-EP318509TEM 11863 mg Ask for price

Hepatitis C virus genotype 1a Genome polyprotein

1-CSB-EP333180HFD
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in E.coli

Hepatitis C virus genotype 1a Genome polyprotein

1-CSB-MP333180HFD
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in Mammalian cell

Recombinant Tick-borne encephalitis virus Far Eastern subtype Genome polyprotein, partial

CSB-EP357187TEN 11862 mg Ask for price

Recombinant Tick-borne encephalitis virus Far Eastern subtype Genome polyprotein, partial

CSB-EP357187TENa0 11843 mg Ask for price

Recombinant Tick-borne encephalitis virus Far Eastern subtype Genome polyprotein, partial

CSB-EP357187TENc7 11839 mg Ask for price

Genome polyprotein Antibody (HRP)

20-abx109095
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  • 100 ug
  • 1 mg
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Genome polyprotein Antibody (HRP)

20-abx300968
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  • 100 ug
  • 1 mg
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Hepatitis C Genome polyprotein

1-CSB-RP184674Ba
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
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  • 50ug
Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli

Genome polyprotein Antibody (HRP)

abx109095-100l 100 µl
EUR 162.5

Genome polyprotein Antibody (HRP)

abx300968-100g 100 µg
EUR 362.5

Genome polyprotein Antibody (HRP)

abx300968-20g 20 µg
EUR 162.5

Genome polyprotein Antibody (HRP)

abx300968-50g 50 µg
EUR 250

Genome polyprotein Antibody (FITC)

20-abx107678
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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Genome polyprotein Antibody (FITC)

20-abx300969
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Genome polyprotein Antibody (FITC)

abx107678-100g 100 µg
EUR 362.5

Genome polyprotein Antibody (FITC)

abx107678-20g 20 µg
EUR 162.5

Genome polyprotein Antibody (FITC)

abx107678-50g 50 µg
EUR 250
Gene expression evaluation utilizing qRT-PCR revealed that the expression degree of the prostaglandin (PG) transporter gene SLCO2A1 decreased in response to microgravity, in keeping with the meta-analysis of microarray datasets. Moreover, the course of gravity affected the expression degree of SLCO2A1, buttressing the discovering that its expression was affected by gravity. These outcomes recommend {that a} meta-analysis of DNA microarray datasets might assist establish new goal genes beforehand missed in particular person microarray analyses.

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