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Sex-dependent gene co-expression in the human body
Many pathophysiological mechanisms in human well being and illness are depending on intercourse. Methods biology approaches are efficiently used to decipher human illness etiology, but the impact of intercourse on gene community biology is generally unknown.
To deal with this, we used RNA-sequencing knowledge of over 700 people spanning 24 tissues from the Genotype-Tissue Expression challenge to generate a whole-body gene co-expression map and quantified the intercourse variations per tissue.
We discovered that of the 13,787 genes analyzed in 24 tissues, 29.5% of the gene co-expression is influenced by intercourse. For instance, skeletal muscle was predominantly enriched with genes co-expressed stronger in males, whereas thyroid primarily contained genes co-expressed stronger in females. This was accompanied by constant sex variations in pathway enrichment, together with hypoxia, epithelial-to-mesenchymal transition, and irritation over the human physique.
Moreover, multi-organ analyses revealed constant sex-dependent gene co-expression over quite a few tissues which was accompanied by enrichment of transcription issue binding motifs within the promoters of those genes.
Lastly, we present that many sex-biased genes are related to sex-biased illnesses, similar to autoimmunity and most cancers, and extra usually the goal of FDA-approved medication than non-sexbiased genes. Our examine means that intercourse impacts organic gene networks by variations in gene co-expression and that spotlight to the impact of intercourse on organic responses to medical medication is warranted.
Structural variants are a serious supply of gene expression variations in people and infrequently have an effect on a number of close by genes
Structural variants (SVs) are an necessary supply of human genome range however their practical results should not properly understood. We mapped 61,668 SVs in 613 people with deep genome sequencing knowledge from the GTEx challenge and measured their results on gene expression. We estimate that widespread SVs are causal at 2.66% of eQTLs, which is a 10.5-fold enrichment relative to their abundance within the genome and in line with prior work utilizing smaller pattern sizes.
Duplications and deletions have been probably the most impactful variant sorts, whereas the contribution of cell ingredient insertions was small (0.12% of eQTLs, 1.9-fold enriched). Multi-tissue evaluation of expression results revealed that gene-altering SVs present considerably extra constitutive results than different variant sorts, with 62.09% of coding SV-eQTLs energetic in all tissues with identified eQTL exercise in comparison with 23.08% of coding SNV- and indel-eQTLs, whereas noncoding SVs, SNVs and indels present broadly comparable patterns.
We additionally recognized 539 uncommon SVs related to close by gene expression outliers. Of those, 62.34% are noncoding SVs that present sturdy results on gene expression but modest enrichment at identified regulatory components, demonstrating that uncommon noncoding SVs are a serious supply of gene expression variations however stay troublesome to foretell from present annotations.
Each widespread and uncommon noncoding SVs usually present sturdy regional results on the expression of a number of genes: SV-eQTLs have an effect on a median of 1.82 close by genes in comparison with 1.09 genes affected by SNV- and indel-eQTLs, and 21.34% of uncommon expression-altering SVs present sturdy results on 2-9 completely different genes. We additionally observe important results on uncommon gene expression changes extending 1 Mb from the SV. This offers a mechanism by which particular person noncoding SVs could have sturdy or pleiotropic results on phenotypic variation and illness.
Technology of ‘designer erythroblasts’ missing a number of blood group programs from CRISPR/Cas9 gene-edited human-induced pluripotent stem cells
Regardless of the current developments in transfusion drugs, crimson blood cell (RBC) alloimmunization stays a problem for multiparous ladies and chronically transfused sufferers. At instances, diagnostic laboratories depend upon difficult-to-procure uncommon reagent RBCs for the identification of various alloantibodies in such topics.
We’ve got addressed this difficulty by creating erythroblasts with customized phenotypes (Rh null, GPB null and Kx null/Kell low) utilizing CRISPR/Cas9 gene-editing of a human induced pluripotent stem cell (hiPSC) father or mother line (OT1-1) for the blood group system genes: RHAG, GYPB and XK. Information RNAs have been cloned into Cas9-puromycin expression vector and transfected into OT1-1.
Genotyping was carried out to pick puromycin-resistant hiPSC KOs. CRISPR/Cas9 gene-editing resulted within the profitable technology of three KO strains, RHAG KO, GYPB KO and XK KO. The OT1-1 cell line, in addition to the three KO hiPSC strains, have been differentiated into CD34+ CD41+ CD235ab+ hematopoietic progenitor cells (HPCs) and subsequently to erythroblasts.
Native OT1-1 erythroblasts have been optimistic for the expression of Rh, MNS, Kell and H blood group programs. Differentiation of RHAG KO, GYPB KO and XK KO resulted within the formation of Rh null, GPB null and Kx null/Kell low erythroblasts, respectively. OT1-1 in addition to the three KO erythroblasts remained optimistic for RBC markers-CD71 and BAND3.
Erythroblasts have been principally on the polychromatic/ orthochromatic stage of differentiation. As much as ~400-fold enhance in erythroblasts derived from HPCs was noticed. The provision of customized erythroblasts generated from CRISPR/Cas9 gene-edited hiPSC needs to be a helpful addition to the instruments at present used for the detection of clinically necessary crimson cell alloantibodies.
Genomic Stability and Genetic Protection Methods in Dolosigranulum pigrum, a Candidate Useful Bacterium from the Human Microbiome
Dolosigranulum pigrum is positively related to indicators of well being in a number of epidemiological research of human nasal microbiota. Data of the essential biology of D. pigrum is a prerequisite for evaluating its potential for future therapeutic use; nevertheless, such knowledge are very restricted. To realize perception into D. pigrum‘s chromosomal construction, pangenome, and genomic stability, we in contrast the genomes of 28 D. pigrum strains that have been collected throughout 20 years.
Phylogenomic evaluation confirmed carefully associated strains circulating over this era and closure of 19 genomes revealed extremely conserved chromosomal synteny. Gene clusters concerned within the mobilome and in protection towards cell genetic components (MGEs) have been enriched within the accent genome versus the core genome.
A scientific evaluation for MGEs recognized the primary candidate D. pigrum prophage and insertion sequence. A scientific evaluation for genetic components that restrict the unfold of MGEs, together with restriction modification (RM), CRISPR-Cas, and deity-named protection programs, revealed strain-level range in host protection programs that localized to particular genomic websites, together with one RM system scorching spot. Evaluation of CRISPR spacers pointed to a wealth of MGEs towards which D. pigrum defends itself.
These outcomes reveal a task for horizontal gene switch and cell genetic components in pressure diversification whereas highlighting that in D. pigrum this happens inside the context of a extremely secure chromosomal group protected by quite a lot of protection mechanisms. IMPORTANCE Dolosigranulum pigrum is a candidate helpful bacterium with potential for future therapeutic use. That is based mostly on its optimistic associations with traits of well being in a number of research of human nasal microbiota throughout the span of human life.
For instance, excessive ranges of D. pigrum nasal colonization in adults predicts the absence of Staphylococcus aureus nasal colonization. Additionally, D. pigrum nasal colonization in younger kids is related to wholesome management teams in research of center ear infections.
Recombinant Hepatitis C virus Genome polyprotein |
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| MBS7037961-5x01mg | MyBiosource | 5x0.1mg | EUR 11785 |
Recombinant Hepatitis C virus Genome polyprotein |
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| MBS7037962-002mg | MyBiosource | 0.02mg | EUR 1400 |
Recombinant Hepatitis C virus Genome polyprotein |
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| MBS7037962-01mg | MyBiosource | 0.1mg | EUR 2365 |
Recombinant Hepatitis C virus Genome polyprotein |
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| MBS7037962-5x01mg | MyBiosource | 5x0.1mg | EUR 10600 |
Hepatitis C virus genotype 1a Genome polyprotein |
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| 1-CSB-EP333180HFD | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in E.coli |
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Hepatitis C virus genotype 1a Genome polyprotein |
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| 1-CSB-MP333180HFD | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1a Genome polyprotein,partial expressed in Mammalian cell |
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Hepatitis C virus genotype 1b Genome polyprotein |
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| 1-CSB-YP530838HVQ(A3) | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast |
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Hepatitis C virus genotype 1b Genome polyprotein |
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| 1-CSB-YP530838HVQ(A4) | Cusabio |
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Description: Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial expressed in Yeast |
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Recombinant Human hepatitis A virus genotype IA Genome polyprotein |
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| MBS1163442-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1130 |
Recombinant Human hepatitis A virus genotype IA Genome polyprotein |
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| MBS1163442-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 875 |
Recombinant Human hepatitis A virus genotype IA Genome polyprotein |
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| MBS1163442-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 1010 |
Recombinant Human hepatitis A virus genotype IA Genome polyprotein |
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| MBS1163442-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 1130 |
Recombinant Human hepatitis A virus genotype IA Genome polyprotein |
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| MBS1163442-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 1245 |
Recombinant Hepatitis C virus Genome polyprotein,partial |
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| AP72393 | SAB | each | Ask for price |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS1087197-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 1200 |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS1087197-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 1710 |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS1197403-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 1200 |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS1197403-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 1710 |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS1041882-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS1018847-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 1200 |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS1018847-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 1710 |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS1017822-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 1200 |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS1017822-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 1710 |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS7083727-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS7060004-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS7060367-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus Genome polyprotein, partial |
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| MBS7060967-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IIA Genome polyprotein |
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| MBS1279215-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Simian hepatitis A virus genotype VI Genome polyprotein |
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| MBS1044911-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 870 |
Recombinant Simian hepatitis A virus genotype VI Genome polyprotein |
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| MBS1044911-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 480 |
Recombinant Simian hepatitis A virus genotype VI Genome polyprotein |
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| MBS1044911-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 700 |
Recombinant Simian hepatitis A virus genotype VI Genome polyprotein |
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| MBS1044911-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 625 |
Recombinant Simian hepatitis A virus genotype VI Genome polyprotein |
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| MBS1044911-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 690 |
Recombinant Simian hepatitis A virus genotype V Genome polyprotein |
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| MBS1013869-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IIIA Genome polyprotein |
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| MBS1431010-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1080 |
Recombinant Human hepatitis A virus genotype IIIA Genome polyprotein |
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| MBS1431010-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 755 |
Recombinant Human hepatitis A virus genotype IIIA Genome polyprotein |
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| MBS1431010-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 915 |
Recombinant Human hepatitis A virus genotype IIIA Genome polyprotein |
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| MBS1431010-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 1010 |
Recombinant Human hepatitis A virus genotype IIIA Genome polyprotein |
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| MBS1431010-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 1110 |
Duck hepatitis A virus polyprotein Polyclonal Antibody |
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| MBS9237550-01mL | MyBiosource | 0.1mL | EUR 415 |
Duck hepatitis A virus polyprotein Polyclonal Antibody |
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| MBS9237550-5x01mL | MyBiosource | 5x0.1mL | EUR 1841 |
Recombinant Hepatitis C virus genotype 4a Genome polyprotein |
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| MBS1079380-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 1085 |
Recombinant Hepatitis C virus genotype 4a Genome polyprotein |
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| MBS1079380-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 675 |
Recombinant Hepatitis C virus genotype 4a Genome polyprotein |
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| MBS1079380-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 840 |
Recombinant Hepatitis C virus genotype 4a Genome polyprotein |
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| MBS1079380-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 790 |
Recombinant Hepatitis C virus genotype 4a Genome polyprotein |
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| MBS1079380-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 980 |
Recombinant Hepatitis GB virus B Genome polyprotein, partial |
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| MBS7085832-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IB Genome polyprotein, partial |
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| MBS1220473-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IA Genome polyprotein, partial |
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| MBS1207515-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IIB Genome polyprotein, partial |
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| MBS1307563-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IA Genome polyprotein, partial |
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| MBS1255162-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IA Genome polyprotein, partial |
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| MBS1251717-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IB Genome polyprotein, partial |
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| MBS1057291-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Simian hepatitis A virus genotype IV Genome polyprotein, partial |
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| MBS1031233-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IA Genome polyprotein, partial |
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| MBS1479676-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human hepatitis A virus genotype IIIB Genome polyprotein, partial |
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| MBS1010551-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| CSB-EP333180HFD | Cusabio | 3004 mg | Ask for price |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| CSB-EP333180HFD-20ug | Cusabio | 20ug | Ask for price |
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Description: 192-325aa |
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Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| CSB-MP333180HFD | Cusabio | 4998 mg | Ask for price |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| CSB-MP333180HFD-20ug | Cusabio | 20ug | Ask for price |
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Description: 192-325aa |
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Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| CSB-YP530838HVQ(A3) | Cusabio | 6465 mg | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| CSB-YP530838HVQ(A3)-20ug | Cusabio | 20ug | Ask for price |
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Description: 2-177aa |
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Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| CSB-YP530838HVQ(A4) | Cusabio | 6466 mg | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| CSB-YP530838HVQ(A4)-20ug | Cusabio | 20ug | Ask for price |
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Description: 192-358aa |
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Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial |
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| AP73727 | SAB | each | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein,partial |
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| AP73728 | SAB | each | Ask for price |
Recombinant Hepatitis C virus genotype 6d Genome polyprotein, partial |
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| MBS1226183-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 6d Genome polyprotein, partial |
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| MBS1226183-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 6h Genome polyprotein, partial |
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| MBS1239793-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 6h Genome polyprotein, partial |
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| MBS1239793-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS1238854-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS1238854-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| MBS1169939-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| MBS1169939-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 2a Genome polyprotein, partial |
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| MBS1185658-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 2a Genome polyprotein, partial |
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| MBS1185658-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 6b Genome polyprotein, partial |
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| MBS1161053-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 6b Genome polyprotein, partial |
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| MBS1161053-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS1134475-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS1081858-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS1081858-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 6a Genome polyprotein, partial |
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| MBS1111818-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 6a Genome polyprotein, partial |
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| MBS1111818-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS1261568-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS1261568-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 2b Genome polyprotein, partial |
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| MBS1066487-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 2b Genome polyprotein, partial |
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| MBS1066487-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 6k Genome polyprotein, partial |
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| MBS1072352-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 6k Genome polyprotein, partial |
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| MBS1072352-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS1004937-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS1004937-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| MBS1005431-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 375 |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| MBS1005431-002mgMammalianCell | MyBiosource | 0.02mg(Mammalian-Cell) | EUR 425 |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| MBS1005431-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 635 |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| MBS1005431-01mgMammalianCell | MyBiosource | 0.1mg(Mammalian-Cell) | EUR 1015 |
Recombinant Hepatitis C virus genotype 1a Genome polyprotein, partial |
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| MBS1005431-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 1925 |
Recombinant Hepatitis C virus genotype 5a Genome polyprotein, partial |
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| MBS1027168-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 5a Genome polyprotein, partial |
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| MBS1027168-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 5a Genome polyprotein, partial |
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| MBS1001699-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 2505 |
Recombinant Hepatitis C virus genotype 5a Genome polyprotein, partial |
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| MBS1001699-1mgYeast | MyBiosource | 1mg(Yeast) | EUR 2980 |
Recombinant Hepatitis C virus genotype 3a Genome polyprotein, partial |
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| MBS7091930-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 3a Genome polyprotein, partial |
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| MBS7091931-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 2c Genome polyprotein, partial |
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| MBS7085011-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 6g Genome polyprotein, partial |
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| MBS7085811-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 3k Genome polyprotein, partial |
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| MBS7086666-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 6a Genome polyprotein, partial |
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| MBS7081854-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 1c Genome polyprotein, partial |
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| MBS7090883-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 3b Genome polyprotein, partial |
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| MBS7091092-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS7097404-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 2a Genome polyprotein, partial |
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| MBS7097910-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS7102489-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 2k Genome polyprotein, partial |
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| MBS7099413-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 1c Genome polyprotein, partial |
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| MBS7094099-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 2b Genome polyprotein, partial |
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| MBS7099644-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS9423307-002mg | MyBiosource | 0.02mg | EUR 505 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS9423307-01mg | MyBiosource | 0.1mg | EUR 895 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS9423307-05mg | MyBiosource | 0.5mg | EUR 1975 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS9423307-5x05mg | MyBiosource | 5x0.5mg | EUR 8735 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS9423308-002mg | MyBiosource | 0.02mg | EUR 505 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS9423308-01mg | MyBiosource | 0.1mg | EUR 895 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS9423308-05mg | MyBiosource | 0.5mg | EUR 1975 |
Recombinant Hepatitis C virus genotype 1b Genome polyprotein, partial |
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| MBS9423308-5x05mg | MyBiosource | 5x0.5mg | EUR 8735 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) (HCV) Genome polyprotein |
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| MBS9420854-002mg | MyBiosource | 0.02mg | EUR 460 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) (HCV) Genome polyprotein |
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| MBS9420854-01mg | MyBiosource | 0.1mg | EUR 795 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) (HCV) Genome polyprotein |
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| MBS9420854-1mg | MyBiosource | 1mg | EUR 2525 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) (HCV) Genome polyprotein |
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| MBS9420854-5x1mg | MyBiosource | 5x1mg | EUR 11205 |
Hepatitis C Genome polyprotein |
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| 1-CSB-RP184674Ba | Cusabio |
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Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli |
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Recombinant Hepatitis C virus H77 Genome polyprotein protein, C-His Tag |
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| MBS156843-005mg | MyBiosource | 0.05mg | EUR 345 |
Recombinant Hepatitis C virus H77 Genome polyprotein protein, C-His Tag |
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| MBS156843-01mg | MyBiosource | 0.1mg | EUR 450 |
Recombinant Hepatitis C virus H77 Genome polyprotein protein, C-His Tag |
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| MBS156843-5x01mg | MyBiosource | 5x0.1mg | EUR 1710 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) (HCV) Genome polyprotein |
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| MBS969708-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 420 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) (HCV) Genome polyprotein |
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| MBS969708-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 695 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) (HCV) Genome polyprotein |
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| MBS969708-05mgYeast | MyBiosource | 0.5mg(Yeast) | EUR 1505 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) (HCV) Genome polyprotein |
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| MBS969708-5x05mgYeast | MyBiosource | 5x0.5mg(Yeast) | EUR 6565 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) (HCV) Genome polyprotein |
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| MBS969709-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 420 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) (HCV) Genome polyprotein |
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| MBS969709-01mgYeast | MyBiosource | 0.1mg(Yeast) | EUR 695 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) (HCV) Genome polyprotein |
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| MBS969709-05mgYeast | MyBiosource | 0.5mg(Yeast) | EUR 1505 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) (HCV) Genome polyprotein |
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| MBS969709-5x05mgYeast | MyBiosource | 5x0.5mg(Yeast) | EUR 6565 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) (HCV) Genome polyprotein(E1),partial |
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| AP70969 | SAB | 1mg | EUR 2826 |
Recombinant Hepatitis C Genome polyprotein |
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| CSB-RP184674Ba | Cusabio | 5430 mg | Ask for price |
Recombinant Hepatitis C Genome polyprotein |
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| CSB-RP184674Ba-20ug | Cusabio | 20ug | Ask for price |
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Description: 1-631aa |
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Recombinant Hepatitis C Genome polyprotein |
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| RPC24458-100ug | Biomatik Corporation | 100ug | EUR 721.6 |
Recombinant Hepatitis C Genome polyprotein |
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| RPC24458-20ug | Biomatik Corporation | 20ug | EUR 448.1 |
Equine Rhinitis A Virus Genome Polyprotein Antibody |
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| abx345840-100g | Abbexa | 100 µg | Ask for price |
Equine Rhinitis A Virus Genome Polyprotein Antibody |
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| abx345840-20g | Abbexa | 20 µg | EUR 250 |
Equine Rhinitis A Virus Genome Polyprotein Antibody |
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| abx345840-50g | Abbexa | 50 µg | EUR 350 |
Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1) |
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| 1-CSB-EP327230HGE | Cusabio |
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Description: Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1(ORF1),partial expressed in E.coli |
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Recombinant Hepatitis C virus polyprotein |
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| MBS1265554-002mg | MyBiosource | 0.02mg | EUR 375 |
Recombinant Hepatitis C virus polyprotein |
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| MBS1265554-01mg | MyBiosource | 0.1mg | EUR 635 |
Recombinant Hepatitis C virus polyprotein |
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| MBS1265554-5x01mg | MyBiosource | 5x0.1mg | EUR 2630 |
Recombinant Hepatitis C virus polyprotein |
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| MBS9422143-001mg | MyBiosource | 0.01mg | EUR 370 |
Recombinant Hepatitis C virus polyprotein |
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| MBS9422143-01mg | MyBiosource | 0.1mg | EUR 795 |
Recombinant Hepatitis C virus polyprotein |
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| MBS9422143-5x01mg | MyBiosource | 5x0.1mg | EUR 3435 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 |
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| MBS1033628-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 375 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 |
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| MBS1033628-01mgEColi | MyBiosource | 0.1mg(E-Coli) | EUR 635 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 |
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| MBS1033628-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 1925 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 |
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| MBS1033628-5x1mgEColi | MyBiosource | 5x1mg(E-Coli) | EUR 8405 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 |
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| MBS9420921-002mg | MyBiosource | 0.02mg | EUR 460 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 |
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| MBS9420921-01mg | MyBiosource | 0.1mg | EUR 795 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 |
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| MBS9420921-1mg | MyBiosource | 1mg | EUR 2525 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 |
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| MBS9420921-5x1mg | MyBiosource | 5x1mg | EUR 11205 |
Japanese Encephalitis Virus Genome polyprotein Antibody |
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| abx345000-100l | Abbexa | 100 µl | EUR 350 |
Japanese Encephalitis Virus Genome polyprotein Antibody |
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| abx345000-50l | Abbexa | 50 µl | EUR 250 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1) |
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| AP71039 | SAB | 1mg | EUR 2826 |
Bovine Viral Diarrhea Virus Genome Polyprotein Antibody |
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| abx345377-100tests | Abbexa | 100 tests | EUR 250 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-1mg |
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| QP6996-1mg | EnQuireBio | 1mg | EUR 3037.2 |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1), partial |
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| CSB-EP327230HGE | Cusabio | 2937 mg | Ask for price |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1), partial |
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| CSB-EP327230HGE-20ug | Cusabio | 20ug | Ask for price |
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Description: 60-240aa |
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Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1), partial |
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| MBS1135179-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1), partial |
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| MBS1308592-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1), partial |
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| MBS1481072-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-10ug |
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| QP6996-10ug | EnQuireBio | 10ug | EUR 426 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-200ug |
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| QP6996-200ug | EnQuireBio | 200ug | EUR 1468.8 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-20ug |
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| QP6996-20ug | EnQuireBio | 20ug | EUR 523.2 |
Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-500ug |
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| QP6996-500ug | EnQuireBio | 500ug | EUR 1936.8 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-1mg |
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| QP8939-ec-1mg | EnQuireBio | 1mg | EUR 2763.6 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-1mg |
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| QP9739-ye-1mg | EnQuireBio | 1mg | EUR 3296.4 |
Anti-Hepatitis C virus/HCV Genome polyprotein Nanobody |
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| MBS1568320-01mg | MyBiosource | 0.1mg | EUR 405 |
Anti-Hepatitis C virus/HCV Genome polyprotein Nanobody |
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| MBS1568320-5x01mg | MyBiosource | 5x0.1mg | EUR 1520 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-10ug |
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| QP8939-ec-10ug | EnQuireBio | 10ug | EUR 391.2 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-50ug |
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| QP8939-ec-50ug | EnQuireBio | 50ug | EUR 522 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-100ug |
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| QP8939-ec-100ug | EnQuireBio | 100ug | EUR 848.4 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-200ug |
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| QP8939-ec-200ug | EnQuireBio | 200ug | EUR 1338 |
Recombinant Hepatitis C Virus polyprotein, His, E.coli-500ug |
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| QP8939-ec-500ug | EnQuireBio | 500ug | EUR 1816.8 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-100ug |
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| QP9739-ye-100ug | EnQuireBio | 100ug | EUR 945.6 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-10ug |
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| QP9739-ye-10ug | EnQuireBio | 10ug | EUR 434.4 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-200ug |
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| QP9739-ye-200ug | EnQuireBio | 200ug | EUR 1512 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-500ug |
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| QP9739-ye-500ug | EnQuireBio | 500ug | EUR 2164.8 |
Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-50ug |
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| QP9739-ye-50ug | EnQuireBio | 50ug | EUR 576 |
Yellow fever virus Genome polyprotein |
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| 1-CSB-EP365905YAC1 | Cusabio |
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Description: Recombinant Yellow fever virus Genome polyprotein,partial expressed in E.coli |
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Rabbit anti-Hepatitis C virus genotype 1a Genome polyprotein polyclonal Antibody |
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| MBS1495141-005mg | MyBiosource | 0.05mg | EUR 190 |
Rabbit anti-Hepatitis C virus genotype 1a Genome polyprotein polyclonal Antibody |
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| MBS1495141-01mg | MyBiosource | 0.1mg | EUR 270 |
Rabbit anti-Hepatitis C virus genotype 1a Genome polyprotein polyclonal Antibody |
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| MBS1495141-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
Anti-Tick-borne encephalitis virus Genome polyprotein Antibody |
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| DZ41264 | BosterBio | 200 μl/vial | EUR 470 |
Recombinant Hepatitis E virus genotype 4 Non-structural polyprotein pORF1 (ORF1), partial |
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| MBS1343728-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Hepatitis E virus genotype 3 Non-structural polyprotein pORF1 (ORF1), partial |
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| MBS1440542-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Potato virus A Genome polyprotein, partial |
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| MBS1371530-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Langat virus Genome polyprotein |
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| MBS1133753-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Langat virus Genome polyprotein |
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| MBS7038287-002mg | MyBiosource | 0.02mg | EUR 1845 |
Recombinant Langat virus Genome polyprotein |
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| MBS7038287-01mg | MyBiosource | 0.1mg | EUR 2775 |
Recombinant Langat virus Genome polyprotein |
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| MBS7038287-5x01mg | MyBiosource | 5x0.1mg | EUR 12450 |
Rabbit anti-Hepatitis C virus genotype 1a Genome polyprotein polyclonal Antibody, FITC |
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| MBS969103-005mg | MyBiosource | 0.05mg | EUR 190 |
Rabbit anti-Hepatitis C virus genotype 1a Genome polyprotein polyclonal Antibody, FITC |
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| MBS969103-01mg | MyBiosource | 0.1mg | EUR 270 |
Rabbit anti-Hepatitis C virus genotype 1a Genome polyprotein polyclonal Antibody, FITC |
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| MBS969103-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
Japanese encephalitis virus Genome polyprotein |
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| 1-CSB-EP189574Ba | Cusabio |
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Description: Recombinant Japanese encephalitis virus Genome polyprotein,partial expressed in E.coli |
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Rabbit anti-Dengue virus Genome polyprotein polyclonal Antibody |
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| MBS1491738-005mg | MyBiosource | 0.05mg | EUR 190 |
Rabbit anti-Dengue virus Genome polyprotein polyclonal Antibody |
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| MBS1491738-01mg | MyBiosource | 0.1mg | EUR 270 |
Rabbit anti-Dengue virus Genome polyprotein polyclonal Antibody |
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| MBS1491738-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
Recombinant Echo 9 virus Genome polyprotein |
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| MBS1066973-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 880 |
Recombinant Echo 9 virus Genome polyprotein |
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| MBS1066973-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 500 |
Recombinant Echo 9 virus Genome polyprotein |
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| MBS1066973-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 700 |
Recombinant Echo 9 virus Genome polyprotein |
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| MBS1066973-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 655 |
Recombinant Echo 9 virus Genome polyprotein |
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| MBS1066973-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 700 |
Recombinant Potato virus Y Genome polyprotein |
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| MBS1185288-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 880 |
Recombinant Potato virus Y Genome polyprotein |
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| MBS1185288-005mgEColi | MyBiosource | 0.05mg(E-Coli) | EUR 495 |
Recombinant Potato virus Y Genome polyprotein |
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| MBS1185288-005mgYeast | MyBiosource | 0.05mg(Yeast) | EUR 695 |
Recombinant Potato virus Y Genome polyprotein |
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| MBS1185288-02mgEColi | MyBiosource | 0.2mg(E-Coli) | EUR 650 |
Recombinant Potato virus Y Genome polyprotein |
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| MBS1185288-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 690 |
Recombinant Potato virus Y Genome polyprotein |
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| MBS1011117-002mgBaculovirus | MyBiosource | 0.02mg(Baculovirus) | EUR 985 |
Recombinant Potato virus Y Genome polyprotein |
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| MBS1011117-002mgEColi | MyBiosource | 0.02mg(E-Coli) | EUR 545 |
Recombinant Potato virus Y Genome polyprotein |
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| MBS1011117-002mgYeast | MyBiosource | 0.02mg(Yeast) | EUR 740 |
Our evaluation of 28 genomes revealed a outstanding stability of D. pigrum strains colonizing individuals in america throughout a 20-year span. We subsequently recognized components that may affect this stability, together with genomic stability, phage predators, the function of MGEs in strain-level variation, and defenses towards MGEs. Lastly, these D. pigrum strains additionally lacked predicted virulence components. Total, these findings add extra help to the potential for D. pigrum as a therapeutic bacterium.
