Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome

Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome

Mutation within the germline is the final word supply of genetic variation, however little is thought concerning the affect of germline chromatin construction on mutational processes. Utilizing ATAC-seq, we profile the open chromatin panorama of human spermatogonia, probably the most proliferative cell kind of the germline, figuring out transcription issue binding websites (TFBSs) and PRDM9-binding websites, a subset of which is able to provoke meiotic recombination.
We observe a rise in uncommon structural variant (SV) breakpoints at PRDM9-bound websites, implicating meiotic recombination within the technology of structural variation. Many germline TFBSs, equivalent to NRF1, are additionally related to elevated charges of SV breakpoints, apparently unbiased of recombination.
Singleton brief insertions (>=5 bp) are extremely enriched at TFBSs, significantly at websites sure by testis energetic TFs, and their charges correlate with these of structural variant breakpoints. Quick insertions typically duplicate the TFBS motif, resulting in clustering of motif websites close to regulatory areas on this male-driven evolutionary course of.
Elevated mutation masses at germline TFBSs disproportionately have an effect on neural enhancers with exercise in spermatogonia, doubtlessly altering neurodevelopmental regulatory structure. Native chromatin construction in spermatogonia is thus pervasive in shaping each evolution and illness.

Human-Related Mechanisms and Threat Elements for TAK-875-Induced Liver Harm Recognized through a Gene Pathway-Based mostly Method in Collaborative Cross Mice

Improvement of TAK-875 was discontinued when a small variety of critical drug-induced liver harm (DILI) circumstances had been noticed in Section Three scientific trials. Subsequent research have recognized hepatocellular oxidative stress, mitochondrial dysfunction, altered bile acid homeostasis, and immune response as mechanisms of TAK-875 DILI and the contribution of genetic threat elements in oxidative response and mitochondrial pathways to the toxicity susceptibility noticed in sufferers.
We examined the speculation {that a} novel preclinical method primarily based on gene pathway evaluation within the livers of Collaborative Cross mice may very well be used to determine human-relevant mechanisms of toxicity and genetic threat elements on the stage of the hepatocyte as reported in a human genome-wide affiliation research.
Eight (8) male mice (four matched pairs) from every of 45 Collaborative Cross strains had been handled with a single oral (gavage) dose of both car or 600 mg/kg TAK-875. As anticipated, liver harm was not detected histologically and few modifications in plasma biomarkers of hepatotoxicity had been noticed.
Nevertheless, gene expression profiling within the liver recognized tons of of transcripts conscious of TAK-875 remedy throughout all strains reflecting alterations in immune response and bile acid homeostasis and the interplay of remedy and pressure reflecting oxidative stress and mitochondrial dysfunction.
Fold-change expression values had been then used to develop pathway-based phenotypes for genetic mapping which recognized candidate threat issue genes for TAK-875 toxicity susceptibility on the stage of the hepatocyte.
Taken collectively, these findings help our speculation {that a} gene pathway-based method utilizing Collaborative Cross mice may inform delicate strains, human-relevant mechanisms of toxicity, and genetic threat elements for TAK-875 DILI. This novel preclinical method could also be useful in understanding, predicting, and in the end stopping scientific DILI for different medication.

Minimal physiologically primarily based pharmacokinetic-pharmacodynamic (mPBPK-PD) mannequin of GalNAc-conjugated siRNA disposition and gene silencing in preclinical species and people

Conjugation of small interfering ribonucleic acid (siRNA) to tris-N-acetylgalactosamine (tris-GalNAc) can allow extremely selective, potent, and sturdy knockdown of focused proteins within the liver. Nevertheless, potential information gaps between in vitro experiments, preclinical species, and scientific eventualities stay.
A minimal physiologically primarily based pharmacokinetic-pharmacodynamic (mPBPK-PD) mannequin for GalNAc-conjugated siRNA (GalNAc-siRNA) was developed utilizing printed information for fitusiran (ALN-AT3), an investigational compound focusing on liver antithrombin (AT), to delineate putative determinants governing the entire body-to-cellular PK-PD of GalNAc-siRNA and facilitate preclinical-to-clinical translation.
The mannequin mathematically linked related mechanisms: i) hepatic biodistribution, ii) tris-GalNAc binding to asialoglycoprotein receptors (ASGPRs) on hepatocytes, iii) ASGPR endocytosis and recycling, iv) endosomal transport and escape of siRNA, v) cytoplasmic RNA-induced silencing complicated (RISC) loading, vi) degradation of goal mRNA by sure RISC, and vii) knockdown of protein.
Physiological values for 36 out of 48 mannequin parameters had been obtained from the literature. Kinetic parameters governing (GalNAc)3-ASGPR binding and internalization had been derived from printed research of uptake in hepatocytes.
The proposed mannequin nicely characterised reported PK, RISC dynamics, and knockdown of AT mRNA and protein by ALN-AT3 in mice. The mannequin bridged a number of PK-PD datasets in preclinical species (mice, rat, monkey) and efficiently captured reported plasma PK and AT knockdown in a Section-I ascending dose research. Estimates of in vivo efficiency (SC50 ) had been related (~2-fold) throughout species.
Subcutaneous absorption and serum AT degradation charge constants scaled throughout species by physique weight with allometric exponents of -0.29 and -0.22. The proposed mechanistic modeling framework characterizes the distinctive PK-PD properties of GalNAc-siRNA. Significance Assertion (GalNAc)3-conjugated siRNA therapeutics allow liver-targeted gene remedy and precision drugs.
Utilizing a translational and systems-based minimal physiologically primarily based pharmacokinetic-pharmacodynamic (mPBPK-PD) modeling method, drug- and system-specific determinants influencing GalNAc-siRNA performance in preclinical species (mice, rats, monkeys) and people had been investigated.
The developed mannequin efficiently built-in and characterised related printed in vitro-derived biomeasures, mechanistic PK-PD profiles in animals, and noticed scientific PK-PD responses for an investigational GalNAc-siRNA (fitusiran). This modeling effort delineates the entire body-to-cellular disposition and liver-targeted pharmacodynamics of GalNAc-siRNA.

Entire Genome Sequencing Hyperlinks Mycobacterium bovis From Cattle, Cheese and People in Baja California, Mexico

Mycobacterium bovis causes tuberculosis (TB) in cattle, which in flip can transmit the pathogen to people. Tuberculosis in dairy cattle is of explicit concern the place the consumption of uncooked milk and dairy merchandise is customary. Baja California (BCA), Mexico, presents excessive prevalence of TB in each cattle and people, making it vital to analyze the molecular epidemiology of the illness within the area.
An extended-term research was undertaken to totally characterize the variety of M. bovis genotypes circulating in dairy cattle, cheese and people in BCA by whole-genome sequencing (WGS). Throughout a 2-year interval, 412 granulomatous tissue samples had been collected from native abattoirs and 314 cheese samples had been bought from native shops and distributors in BCA and despatched to the laboratory for mycobacterial tradition, histology, direct PCR and WGS. For tissue samples M. bovis was recovered from 86.8%, direct PCR detected 90% and histology confirmed 85.9% as mycobacteriosis-compatible.
For cheese, M. bovis was recovered from 2.5% and direct PCR detected 6% of the samples. There was good settlement between diagnostic exams. Subsequently, a complete of 345 whole-genome SNP sequences had been obtained. Phylogenetic evaluation grouped these isolates into 10 main clades. SNP evaluation revealed putative transmission clusters the place the pairwise SNP distance between isolates from totally different dairies was ≤Three SNP.
Additionally, human and/or cheese isolates had been inside 8.45 (vary 0-17) and 5.Eight SNP (vary 0-15), respectively, from cattle isolates. Lastly, a comparability between the genotypes obtained on this research and people reported beforehand means that the genetic variety of M. bovis in BCA is well-characterized, and can be utilized to find out if BCA is the seemingly supply of M. bovis in people and cattle in routine epidemiologic investigations and future research. In conclusion,

Hepatitis C Genome polyprotein

1-CSB-RP184674Ba
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 71.3 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Hepatitis C Genome polyprotein expressed in E.coli

Recombinant Hepatitis C Virus NS3 Genotype-1b

7-07246 100µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-1b

7-07247 500µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-1b

7-07248 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-1b

7-07342 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-1b

7-07343 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-1b

7-07344 1000µg Ask for price

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-100ug

QP9739-ye-100ug 100ug
EUR 788

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-10ug

QP9739-ye-10ug 10ug
EUR 362

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-1mg

QP9739-ye-1mg 1mg
EUR 2747

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-200ug

QP9739-ye-200ug 200ug
EUR 1260

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-500ug

QP9739-ye-500ug 500ug
EUR 1804

Recombinant Hepatitis C virus genotype 1b (strain HC-J4) polyprotein, His, Yeast-50ug

QP9739-ye-50ug 50ug
EUR 480

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-1b

7-07177 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-1b

7-07178 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-1b

7-07179 1000µg Ask for price

Hepatitis C Virus NS3 Genotype-1b Protein

20-abx260126
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-1b Protein

20-abx260240
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS3 Genotype-1b protein

30R-AH052 500 ug
EUR 806
Description: Hepatitis C Virus NS3 Genotype-1b recombinant protein

Recombinant Hepatitis C Virus NS3 Genotype-1b (1192-1459)

7-07243 100µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-1b (1192-1459)

7-07244 500µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-1b (1192-1459)

7-07245 1000µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-1b (1356-1459)

7-07249 100µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-1b (1356-1459)

7-07250 500µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-1b (1356-1459)

7-07251 1000µg Ask for price

Japanese encephalitis virus Genome polyprotein

1-CSB-EP189574Ba
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 90.4 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Japanese encephalitis virus Genome polyprotein,partial expressed in E.coli

Yellow fever virus Genome polyprotein

1-CSB-EP365905YAC1
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 78.4 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Yellow fever virus Genome polyprotein,partial expressed in E.coli

Recombinant (E.Coli) Hepatitis C Virus (HCV) Nucleocapsid (core) Genotype-1b

RP-503 100 ug
EUR 286

Hepatitis C Virus NS3 Genotype-1b (1192-1459) Protein

20-abx260250
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS3 Genotype-1b (1356-1459) Protein

20-abx260252
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Recombinant (E.Coli, His-tag) Hepatitis C Virus (HCV) NS3 Genotype-1b

RP-461 100 ug
EUR 286

Recombinant (E.Coli, GST tag) Hepatitis C Virus (HCV) NS5 Genotype-1b

RP-486 100 ug
EUR 286

Recombinant (E.Coli) Hepatitis C Virus (HCV) NS3 Genotype-1b (1192-1459)

RP-505 100 ug
EUR 286

Recombinant (E.Coli) Hepatitis C Virus (HCV) NS3 Genotype-1b (1356-1459)

RP-507 100 ug
EUR 286

Recombinant Hepatitis C Virus NS3 Genotype-1c 

7-07252 100µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-1c 

7-07253 500µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-1c 

7-07254 1000µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-5a 

7-07279 100µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-5a 

7-07280 500µg Ask for price

Recombinant Hepatitis C Virus NS3 Genotype-5a 

7-07281 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-1 

7-07333 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-1 

7-07334 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-1 

7-07335 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-1a

7-07339 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-1a

7-07340 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-1a

7-07341 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-2 

7-07345 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-2 

7-07346 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-2 

7-07347 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-2a 

7-07348 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-2a 

7-07349 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-2a 

7-07350 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-2b

7-07351 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-2b

7-07352 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-2b

7-07353 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-3 

7-07354 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-3 

7-07355 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-3 

7-07356 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-3a 

7-07357 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-3a 

7-07358 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-3a 

7-07359 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-3b 

7-07360 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-3b 

7-07361 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-3b 

7-07362 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-4 

7-07363 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-4 

7-07364 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-4 

7-07365 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-5 

7-07366 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-5 

7-07367 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-5 

7-07368 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-6 

7-07369 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-6 

7-07370 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-6 

7-07371 1000µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-6a

7-07372 100µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-6a

7-07373 500µg Ask for price

Recombinant Hepatitis C Virus NS5 Genotype-6a

7-07374 1000µg Ask for price

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-10ug

QP6996-10ug 10ug
EUR 355

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-1mg

QP6996-1mg 1mg
EUR 2531

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-200ug

QP6996-200ug 200ug
EUR 1224

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-20ug

QP6996-20ug 20ug
EUR 436

Recombinant Hepatitis C virus genotype 1a (isolate 1) polyprotein, His-SUMO, Mammal-500ug

QP6996-500ug 500ug
EUR 1614

Hepatitis E virus genotype 1 Non-structural polyprotein pORF1 (ORF1)

1-CSB-EP327230HGE
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 24.4 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Hepatitis E virus genotype 1 Non-structural polyprotein pORF1(ORF1),partial expressed in E.coli

Recombinant Hepatitis C Virus polyprotein, His, E.coli-100ug

QP8939-ec-100ug 100ug
EUR 707

Recombinant Hepatitis C Virus polyprotein, His, E.coli-10ug

QP8939-ec-10ug 10ug
EUR 326

Recombinant Hepatitis C Virus polyprotein, His, E.coli-1mg

QP8939-ec-1mg 1mg
EUR 2303

Recombinant Hepatitis C Virus polyprotein, His, E.coli-200ug

QP8939-ec-200ug 200ug
EUR 1115

Recombinant Hepatitis C Virus polyprotein, His, E.coli-500ug

QP8939-ec-500ug 500ug
EUR 1514

Recombinant Hepatitis C Virus polyprotein, His, E.coli-50ug

QP8939-ec-50ug 50ug
EUR 435

Genome Polyprotein Antibody

20-abx109417
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Genome polyprotein Antibody

20-abx300967
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Genome polyprotein Antibody

1-CSB-PA362073LA01HQD
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human rhinovirus A serotype 89. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA333180LA01HFD
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Hepatitis C virus genotype 1a. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA714772LA01HYH
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Human enterovirus 71. This antibody is Unconjugated. Tested in the following application: ELISA

Genome polyprotein Antibody

1-CSB-PA18549A0Rb
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 >95%, Protein G purified
Description: A polyclonal antibody against Genome polyprotein. Recognizes Genome polyprotein from Dengue virus. This antibody is Unconjugated. Tested in the following application: ELISA

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-1

7-07171 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-1

7-07172 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-1

7-07173 1000µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-1a

7-07174 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-1a

7-07175 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-1a

7-07176 1000µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-2a

7-07180 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-2a

7-07181 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-2a

7-07182 1000µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-2b

7-07183 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-2b

7-07184 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-2b

7-07185 1000µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-3a

7-07186 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-3a

7-07187 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-3a

7-07188 1000µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-3b

7-07189 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-3b

7-07190 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-3b

7-07191 1000µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-4

7-07192 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-4

7-07193 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-4

7-07194 1000µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-5

7-07195 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-5

7-07196 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-5

7-07197 1000µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-6a

7-07198 100µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-6a

7-07199 500µg Ask for price

Recombinant Hepatitis C Virus Nucleocapsid (core) Genotype-6a

7-07200 1000µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-1       

7-07303 100µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-1       

7-07304 500µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-1       

7-07305 1000µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-2         

7-07306 100µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-2         

7-07307 500µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-2         

7-07308 1000µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-3         

7-07309 100µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-3         

7-07310 500µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-3         

7-07311 1000µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-5        

7-07312 100µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-5        

7-07313 500µg Ask for price

Recombinant Mosaic Hepatitis C Virus NS4 Genotype-5        

7-07314 1000µg Ask for price

Recombinant (E.Coli, GST-tag) Hepatitis C Virus (HCV) NS5, Biotin Labled, Genotype-1b

RP-494 50 ug
EUR 286

Hepatitis C Virus NS3 Genotype-1c Protein

20-abx260130
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS3 Genotype-5a Protein

20-abx260131
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-1 Protein

20-abx260132
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-3 Protein

20-abx260133
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-6 Protein

20-abx260134
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-2 Protein

20-abx260135
  • EUR 885.00
  • EUR 342.00
  • EUR 1372.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-4 Protein

20-abx260237
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-5 Protein

20-abx260238
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-1a Protein

20-abx260239
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-2a Protein

20-abx260241
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-2b Protein

20-abx260242
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-3a Protein

20-abx260243
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-3b Protein

20-abx260244
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS5 Genotype-6a Protein

20-abx260245
  • EUR 885.00
  • EUR 342.00
  • EUR 1609.00
  • 0.5 mg
  • 100 ug
  • 1 mg
  • Shipped within 5-10 working days.

Hepatitis C Virus NS3 Genotype 1a protein

30R-AH005 1 mg
EUR 1537
Description: Purified recombinant Hepatitis C Virus NS3 Genotype 1a protein
WGS supplied proof of ongoing native transmission of M. bovis among the many dairies on this high-TB burden area of BCA, in addition to present shut relationships between isolates recovered from people, cheese, and cattle. This confirms the necessity for a coordinated One Well being method in addressing the elimination of TB in animals and people. Total, the research contributes to the information of the molecular epidemiology of M. bovis in BCA, offering perception into the pathogen’s dynamics in a excessive prevalence setting.

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