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Tag: pcdna3.1

Butein exhibits anti-tumor effect through intrinsic pathway of apoptosis, vimentin proteolysis, and inhibition of cancer stem cell population in the human papillary thyroid cancer cell line

Epithelial-mesenchymal transition (EMT) and most cancers stem cells (CSCs) play a vital function in metastasis of papillary thyroid most cancers (PTC). Additional mesenchymal marker vimentin is linked with metastasis and most cancers stem cell technology. Therefore, inhibition of EMT and Read more…


NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis

NOX1/NADPH oxidase is involved in the LPS-induced exacerbation of collagen-induced arthritis

We examine as but an unidentified position of NOX1, a non-phagocytic isoform of the superoxide-generating NADPH oxidase, in immune responses utilizing Nox1-knockout mice (Nox1-KO). The transcripts of NOX1 was expressed in lymphoid tissues, together with the spleen, thymus, bone marrow, and inguinal lymphoid nodes. Read more…


Cetuximab-siRNA Conjugate Linked Through Cationized Gelatin Knocks Down KRAS G12C Mutation in NSCLC Sensitizing the Cells Toward Gefitinib

Cetuximab-siRNA Conjugate Linked Through Cationized Gelatin Knocks Down KRAS G12C Mutation in NSCLC Sensitizing the Cells Toward Gefitinib

Supply of small-interfering RNA (siRNA) has been of nice curiosity prior to now decade for efficient gene silencing. To beat artificial and regulatory challenges posed by nanoparticle-mediated siRNA supply, antibody-siRNA conjugate (ARC) platform is rising as a possible siRNA supply Read more…