The Impact of Monoclonal Antibodies on Airway Smooth Muscle Contractility in Asthma: A Systematic Review

The Impact of Monoclonal Antibodies on Airway Smooth Muscle Contractility in Asthma: A Systematic Review

Airway hyperresponsiveness (AHR) represents a central pathophysiological hallmark of bronchial asthma, with airway clean muscle (ASM) being the effector tissue implicated within the onset of AHR. ASM additionally exerts pro-inflammatory and immunomodulatory actions, by secreting a variety of cytokines and chemokines. In bronchial asthma pathogenesis, the overexpression of a number of sort 2 inflammatory mediators together…

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