Argentine Bioethics Association

Description: Description of target: Transforming growth factor beta 3 (TGF-beta 3) is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily. TGF-beta 3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-beta 3, mammals develop a deformity known as acleft palate. This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-beta 3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue, and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin. TGF-beta 3 activated Lef1 in the absence of beta-catenin (CTNNB1) via nuclear phospho-Smad2 and Smad4.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Description: Description of target: Transforming growth factor beta 3 (TGF-beta 3) is a type of protein, known as a cytokine, which is involved in cell differentiation, embryogenesis and development. It belongs to a large family of cytokines called the Transforming growth factor beta superfamily. TGF-beta 3 is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-beta 3, mammals develop a deformity known as acleft palate. This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-beta 3 also plays an essential role in controlling the development of lungs in mammals, by also regulating cell adhesion and ECM formation in this tissue, and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin. TGF-beta 3 activated Lef1 in the absence of beta-catenin (CTNNB1) via nuclear phospho-Smad2 and Smad4.;Species reactivity: Rat;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Description: For quantitative detection of activated human TGF beta 1 in cell culture supernates, serum, plasma(EDTA) and urine.

Description: For quantitative detection of activated rat TGF beta 1 in cell culture supernates, serum, plasma(EDTA) and urine.

Description: For quantitative detection of activated mouse TGF beta1 in cell culture supernates, serum, plasma(EDTA) and urine.

Description: For quantitative detection of activated human TGF-beta 2 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Description: For quantitative detection of activated rat TGF-beta 2 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Description: For quantitative detection of activated mouse TGF-beta 2 in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Description: For quantitative detection of activated human TGF-beta 3 in cell culture supernates, serum, plasma(EDTA) and urine.

Description: For quantitative detection of activated mouse TGF-beta 3 in cell culture supernates, serum, plasma(EDTA) and urine.

Description: For quantitative detection of activated rat TGF-beta 3 in cell culture supernates, serum, plasma(EDTA) and urine.

Description: Enzyme-linked immunosorbent assay kit for quantification of Human TGF-Beta 2 in samples from serum, plasma, tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay kit for quantification of Rat TGF-Beta 2 in samples from serum, plasma, tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse TGF-Beta 2 in samples from serum, plasma, tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay kit for quantification of Human TGF-Beta 3 in samples from serum, plasma, tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse TGF-Beta 3 in samples from serum, plasma, tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay kit for quantification of Rat TGF-Beta 3 in samples from serum, plasma, tissue homogenates and other biological fluids.